Protein Alignment Pde9 and Pde8a

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_032829.1
• Gene: Pde8a / 18584
• MGIID: 1277116
• Length: 823
• Species: Mus musculus
• Alignment Length: 870
• Identity: 198/870 - (22%)
• Similarity: 318/870 - (36%)
• Gaps: 256/870 - (29%)

  Fly   306 HPSEKPERTDIEEEPPPAIAVTTTTTATVRRKSSSSSTISGTATVSGSVSVSASASQ----SFCS 366
            |...:.|..|: :.|.||       ..:::|.|::...:......:|:..||.:..|    .|..
Mouse    17 HSDGEDEDVDV-DVPGPA-------PRSIQRWSTAPGLVEPQPRDNGASKVSVADVQFGPMRFHQ 73

  Fly   367 NNINLLEELLIQFYEE-------------------------------QDHRSNLTVIRHHHHQQH 400
            :.:    ::|:.|.:|                               ||...::.:|.|.:.:|.
Mouse    74 DQL----QVLLVFTKEDSQCNGFHRACEKAGFKCTVTKEVQTVLTCFQDKLHDIIIIDHRYPRQM 134

  Fly   401 QQHQQQQRITNNNNNNNN-----CNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQPTS 460
            ......:.|.::..:.|.     ...:....:...|...|..|.. .:|.|......|..||
Mouse   135 DAETLCRSIRSSKFSENTVIVGVVRRVDKEESSLMPFLAAGFTRR-FIENPNVMACYNELLQ--- 195

  Fly   461 LPDGSDNPR-RRRASDCSAVQAALQNQLHC--ITLKNNNCGKAMPFHRGSCG-AAGEHL---LAA 518
            |..|....: :.||  |::|..||:.....  ||.:::....|.|....:.| .:||.:   ||.
Mouse   196 LACGEVRSQLKLRA--CNSVFTALEKSQEAIEITSEDHIIQYANPAFESTMGYQSGELIGKELAQ 258

  Fly   519 NSIANRATIILS--KSCSNVDGDATATAATALSSTVGGGIG---------GIGGSIKMRASATDI 572
            ..|..:...:|.  .||..||.:......|...:  |..|.         |.||.|:...|
Mouse   259 VPINEKKGDLLDAINSCVTVDKEWQGVYHTQKKN--GDNIQQNVKIIPVIGQGGKIRHYVS---- 317

  Fly   573 ETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTE 637
                       |:...||||.            ::.....:|.....|:.....|| :||    .
Mouse   318 -----------IIRVCNGNNK------------VETTTECVQTDSQTDNQAGKHKD-RRK----H 354

  Fly   638 RMNWLCLSKR--PLGPPHRKSSLPK-HQ--------------------------EVKRRFLEICD 673
            .|:...:|.|  .:....|.|||.: |.                          |...|.|:|..
Mouse   355 SMDAKAVSSRTSDVSSQRRHSSLARIHSMMIEAPITKVINIINAAQENSPVPVTEALNRVLDILR 419

  Fly   674 TT-----------------------------FS--EEVRAALRLP-------------------- 687
            ||                             ||  |.:.|...||
Mouse   420 TTELYSPQFNAQDDPHATDLVGGLMSDGLRRFSGNEYILATKNLPPLSNNLATPVSLHDVPPRIA 484

  Fly   688 -AFDSYEWSDADV------------IHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEV-P 738
             |.::.|..|.|:            |:|....|...|..|.......|||.|...:..:|:.. |
Mouse   485 LAIENEEQWDFDIFELEVATQNRPLIYLGLKTFARFGMCEFLQCSETTLRSWFQMIESNYHSSNP 549

  Fly   739 FHNFRHCFCVAQMMYAITRQANLLSR------LGDLECLILLVSCICHDLDHPGYNNIYQINART 797
            :||..|   .|.:::|   .|..|||      |..::.:..|::...||:||||..|.:..||..
Mouse   550 YHNSTH---AADVLHA---TAYFLSRDKIKETLDRIDEVAALIAATVHDVDHPGRTNSFLCNAGN 608

  Fly   798 ELALRYNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILT 861
            :||:.|||.:.||:||.::||:| ||:.:|||||...|:.:..:|:.||..:|||:|.:|.|.:.
Mouse   609 QLAVLYNDTAVLESHHVALAFQLTLENDQCNIFKQMERNDYRTLRQSIIDMVLATEMTKHFEHVN 673

  Fly   862 QF-------------------------MEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVA 901
            :|                         |..||    .:||   |:..::||.||:||..||::..
Mouse   674 KFINSINKPLTAQESEEPDRSLEDIKAMLKTP----ESRA---LIKRMMIKCADVSNPCRPLEHC 731

  Fly   902 EPWLDRLLQEFFAQSAAEKSEGLPVT-PFMDPDKVSKPGSQVRFIGLVLLPLFEALGELV--PEL 963
            ..|..|:.:|:|:|:..||...|||. |..|.:..|.|.||:.||...:..:|:|....|  |.|
Mouse   732 IEWAARISEEYFSQTDEEKQLDLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPNL 796

  Fly   964 TELIIIPVRIALEYYRRLNDAQTKT 988
            .:.:....|    |::.|::.:.::
Mouse   797 MQHLDDNFR----YWKGLDEKKLRS 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	87/262 (33%)
Pde8a	NP_032829.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		8/45 (18%)
		OmpR	78..>155	CDD:223816	10/76 (13%)
		REC	79..>165	CDD:302758	10/85 (12%)
		PAS_9	222..320	CDD:290162	24/114 (21%)
		PAS	226..320	CDD:238075	24/110 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..373		8/39 (21%)
		PDEase_I	550..801	CDD:278654	87/263 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2223
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950