Protein Alignment Pde9 and Pde7a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001116231.1
• Gene: Pde7a / 18583
• MGIID: 1202402
• Length: 482
• Species: Mus musculus
• Alignment Length: 295
• Identity: 87/295 - (29%)
• Similarity: 142/295 - (48%)
• Gaps: 12/295 - (4%)

  Fly   669 LEICDTTFSEEVRAALRLPA---FDSYEW----SDADVIHLMQTMFVELGFIEKFSIPVDTLREW 726
            |:|.|..::.:.:..|....   ||.:.:    :...::.|...:|...|.||.|.:.:..||.:
Mouse   133 LDILDEDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRF 197

  Fly   727 LYEVYKHY-NEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNI 790
            |..:.:.| ::.|:||..|...|.|.|:...::..|.|.:...:.|:.|::...|||||||.|..
Mouse   198 LVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASSVTPWDILLSLIAAATHDLDHPGVNQP 262

  Fly   791 YQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMAR 855
            :.|.....||..|.:.|.|||||...|..||.  |..:|.:...::...:...|...|||||::|
Mouse   263 FLIKTNHYLATLYKNSSVLENHHWRSAVGLLR--ESGLFSHLPLESRQEMEAQIGALILATDISR 325

  Fly   856 HNEILTQFMEITPIFD--YSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAA 918
            .||.|:.|.......|  ..:..|.:|:..:.:|.|||.|..|..::::.|.:::.:|||.|...
Mouse   326 QNEYLSLFRSHLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDI 390

  Fly   919 EKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLF 953
            ||...|.|:|..|....|....|:.|:..::.|||
Mouse   391 EKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLF 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	70/217 (32%)
Pde7a	NP_001116231.1	PDEase_I	211..431	CDD:459723	70/217 (32%)