Protein Alignment Pde9 and Pde4a

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_899668.1
• Gene: Pde4a / 18577
• MGIID: 99558
• Length: 844
• Species: Mus musculus
• Alignment Length: 552
• Identity: 140/552 - (25%)
• Similarity: 225/552 - (40%)
• Gaps: 140/552 - (25%)

  Fly   702 LMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYN-EVPFHNFRHCFCVAQMMYAITRQANLLSRL 765
            :|.|:|.|...::||.|||||:..::..:..||: :|.:||..|...|.|..:.:.....|.:..
Mouse   380 IMYTIFQERDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVF 444

  Fly   766 GDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFK 830
            .|||.|..|.:...||:||||.:|.:.||..:||||.|||.|.|||||.::.|:||:...|:||:
Mouse   445 TDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQ 509

  Fly   831 NFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP-----------IFDYSNRAHINLLCMI 884
            |.|:....::|:.:|..:|||||::|..:|.....:..           :.:||:|..:   ...
Mouse   510 NLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQV---LRN 571

  Fly   885 LIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVL 949
            ::..||:||..:|:::...|.||::.|||.|...|:..|:.::|..|....|...|||.||..::
Mouse   572 MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV 636

  Fly   950 LPLFEALGELV-PELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAA 1013
            .||:|...:|| |:..:::                   .|.:...|...||...|.|.|::..
Mouse   637 HPLWETWADLVHPDAQDIL-------------------DTLEDNRDWYHSAIRQSPSPTLEEE-- 680

  Fly  1014 MVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISV 1078
                ||..||                                           |.:|.
Mouse   681 ----PGVLSD-------------------------------------------PALPD------- 691

  Fly  1079 KSRRSIPSQKSASRTSVDEPGGMASE-----LHD-----LPEGSESGDSETATEVDVAEKTSKFK 1133
            |.:..:..::.....|::.||...:|     .||     :.:....|.|...  |:|||...:..
Mouse   692 KFQFELTLEEEDEEDSLEVPGLPCTEETLLAPHDTRAQAMEQSKVKGQSPAV--VEVAESLKQET 754

  Fly  1134 VDTEGSSNRSKSS--HSTSRKS-----------SREKR-----PSMIGELCSSGGGQRIRNSYGN 1180
            ....|:...|..:  ||.|.::           |.|.:     |||..|:
Mouse   755 ASAHGAPEESAEAVGHSFSLETSILPDLRTLSPSEEAQGLLGLPSMAAEV--------------- 804

  Fly  1181 IHGYHSNRCHFGNNRAVSLDQYSSAGNNRRLS 1212
                .:.|.|....||.|....:|..|:..:|
Mouse   805 ----EAPRDHLAAMRACSACSGTSGDNSAVIS 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	81/239 (34%)
Pde4a	NP_899668.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..124
		PDEase_I	418..659	CDD:278654	82/262 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..844		3/14 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820