Protein Alignment Pde9 and Pde3b

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_035185.2
• Gene: Pde3b / 18576
• MGIID: 1333863
• Length: 1099
• Species: Mus musculus
• Alignment Length: 825
• Identity: 181/825 - (21%)
• Similarity: 281/825 - (34%)
• Gaps: 273/825 - (33%)

  Fly   320 PPPAIAVTTTTTATV---RRKSSSSSTISGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYE 381
            |||..|.|......|   ||:||..|.....|...||..:....|....|.     |::::..::
Mouse   252 PPPRSASTAEEKVPVIRPRRRSSCVSLGESAAGYYGSGKMFRRPSLPCISR-----EQMILWDWD 311

  Fly   382 EQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCNSIQNN-NNM--------SNPAATAAA 437
            .:              |..:.|.|     |:...|....|:.|. .||        |.|....::
Mouse   312 LK--------------QWCKPHYQ-----NSGGGNGVDLSVLNEARNMVSDLLIDPSLPPQVISS 357

  Fly   438 --------------------TATP--------SVEQPATSGTTNIH---LQPTSLPDGSDNPRRR 471
                                :.||        .||.|...|...:|   ...||.|    .|:.|
Mouse   358 LRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSGRTSFP----TPQLR 418

  Fly   472 RASDCSAVQAALQNQLHC--------------ITLKNNNCGKAMPF------------------- 503
            |:|..|::   |.|: ||              :::.::.|....||
Mouse   419 RSSGASSL---LTNE-HCSRWDRSSGKRSYQELSVSSHGCHLNGPFSSNLFTIPKQRSSSVSLTH 479

  Fly   504 HRG--SCGAAGEHLL---------AANSIANRA--------------TIILSKSCSNVDGDATAT 543
            |.|  ..||...|.|         :|.|:.||:              .|||.:|..:|
Mouse   480 HAGLRRAGALPSHSLLNSSSHVPVSAGSLTNRSPIGFPDTTDFLTKPNIILHRSLGSV------- 537

  Fly   544 AATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQL 608
                                   :||.|......|.  |:.:.|:.|            :.||:.
Mouse   538 -----------------------SSAADFHQYLRNS--DSNLCSSCG------------HQILKY 565

  Fly   609 NNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICD 673
            .:|   |..:..|..:         |.:...:....||.||.....:......:..:..||| .|
Mouse   566 VST---CEPDGTDHPS---------EKSGEEDSSVFSKEPLNIVETQEEETMKKACRELFLE-GD 617

  Fly   674 TTFSEEVRA----------ALRLPAFDSY-------------------EWSDADVIHLMQTMFVE 709
            :...||.:.          .:.:..:||.                   |.|...:..:|.|:|.:
Mouse   618 SHLMEEAQQPNIDQEVSLDPMLVEDYDSLIEKMNNWNFQIFELVEKMGEKSGRILSQVMYTLFQD 682

  Fly   710 LGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAIT-----------------R 757
            .|.:|.|.||......:...:...|.::|:||..|...|...::.:|                 .
Mouse   683 TGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYLTTRPIPGLPQIHNNHETET 747

  Fly   758 QANLLSRLGD---------------------------LECLILLVSCICHDLDHPGYNNIYQINA 795
            :|:...|||.                           ||.:.|.|:...||.||||..|.:.:..
Mouse   748 KADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVAT 812

  Fly   796 RTELALRYNDISPLENHHCSIAFRL-LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEI 859
            ....|:.|||.|.|||||.:.|:.| |..||.|...|.....|...|..:|..|||||:.:|.:.
Mouse   813 NAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFDF 877

  Fly   860 LTQF-MEITPI----FDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAE 919
            |.:| .:...:    .::|:.....|:|.:.||:|||:..|:..|:...|.:.::.||:.|...|
Mouse   878 LAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEE 942

  Fly   920 KSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPL---FEALGELVP 961
            .:.|||::||||.........|..||..::.||   ::|.| |:|
Mouse   943 ATLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAG-LLP 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	79/276 (29%)
Pde3b	NP_035185.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Interaction with RAPGEF3. /evidence=ECO:0000250|UniProtKB:Q13370	1..28
		CynX	<119..260	CDD:442057	4/7 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..423		8/26 (31%)
		Interaction with PIK3R6. /evidence=ECO:0000250|UniProtKB:Q13370	415..439		9/27 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..590		2/28 (7%)
		PDEase_I	712..986	CDD:459723	78/274 (28%)