Protein Alignment Pde9 and Pde1b

DIOPT Version :9

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_032826.1
• Gene: Pde1b / 18574
• MGIID: 97523
• Length: 535
• Species: Mus musculus
• Alignment Length: 507
• Identity: 124/507 - (24%)
• Similarity: 199/507 - (39%)
• Gaps: 115/507 - (22%)

  Fly   603 YSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYT------------------------------- 636
            |.:.||.|..:.           :::||:.:|||
Mouse    40 YMVKQLENGEVN-----------IEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVP 93

  Fly   637 -ERMNWLC--LSKRPLGPPHRKSSLPKHQEVK-------------RRFLEICDTTFSEEVRAALR 685
             |..:||.  .:::......|....||.:.:.             ||.......|:|..|...|:
Mouse    94 SEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCLK 158

  Fly   686 ---LPAFDSYEWSDADVIHLMQTMFVEL----GFIEKFSIPVDTLREWL------YEVYKHYNEV 737
               |..||.:..:.|...|.::|:..||    ..|.:|.||...|..:|      |..||:
Mouse   159 NLDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKN---- 219

  Fly   738 PFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALR 802
            |:||..|...|.|.::....:..::..|.::|.|.::.:...||.:|.|..|.:.|..::|.|:.
Mouse   220 PYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIL 284

  Fly   803 YNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEIT 867
            |||.|.|||||.|..||:::..|.|||.|.::|.|..:|..:|..:|||||:.|   ..|...:.
Mouse   285 YNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCH---FQQVKTMK 346

  Fly   868 PIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDP 932
            .......|...:....:|:..||||:..:...|...|...|::|||.|...|...|||.:|..|.
Mouse   347 TALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDR 411

  Fly   933 DKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKS------ 991
            .......||:.||..::.|.|..|    .::.|..:.|:..        :|::.|::.|
Mouse   412 TSTLVAQSQIGFIDFIVEPTFSVL----TDVAEKSVQPLAD--------DDSKPKSQPSFQWRQP 464

  Fly   992 -----VADSNTSATS---------DSNSGTIDSNAAMVSTPGGASDKLSLDK 1029
                 |.|.|....|         ..|.......||     .|.::::|:|:
Mouse   465 SLDVDVGDPNPDVVSFRATWTKYIQENKQKWKERAA-----SGITNQMSIDE 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	71/227 (31%)
Pde1b	NP_032826.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Calmodulin-binding. /evidence=ECO:0000255	27..47		3/6 (50%)
		PDEase_I_N	80..136	CDD:285672	6/55 (11%)
		PDEase_I	221..448	CDD:278654	72/233 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..474		6/37 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..535		5/22 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920