Protein Alignment Pde9 and pde-3

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_001293571.1
• Gene: pde-3 / 183981
• WormBaseID: WBGene00008443
• Length: 693
• Species: Caenorhabditis elegans
• Alignment Length: 716
• Identity: 162/716 - (22%)
• Similarity: 265/716 - (37%)
• Gaps: 159/716 - (22%)

  Fly   395 HHHQQHQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNI----- 454
            |.:.||..||.......:.:...:....:|.:.    |.::.|::..|::|...|.|.|.
 Worm    28 HQYFQHHYHQTPPGKLRDRSPRLSAEMRKNRDT----ATSSPASSGVSIQQRRGSTTQNSGVGSI 88

  Fly   455 ----------------HLQ----------PTSLPDG--SDNPRRRRASDCSAVQAALQNQLHCIT 491
                            |:|          .||||..  |.|..:...|..|..:..:.:.|
 Worm    89 GLPVLGGRGRGVMSDGHMQRTFHEAMRQRRTSLPANSLSLNGAKVTGSSLSEAKGLIADML---- 149

  Fly   492 LKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRATIILSKSCSNVDGDATATAATALSSTVGGGI 556
                 ..|.:|.:..||..|             .|::|.:....::|........::.....||.
 Worm   150 -----MNKELPGNVASCLRA-------------VTMLLEQRPLPLNGLLNDFGLPSVVENPYGGE 196

  Fly   557 GGIGGSIKMR---------ASATDIETNAL--NGARDAIVASNNGNNGNNGNNGNNEYSILQLNN 610
            ..:.|:.|.|         .|||.:.|...  |.||.:.......:..|     |||:      .
 Worm   197 SMVVGASKPRISNITFSTVTSATGLPTVPAEPNKARSSSYWKTEASPSN-----NNEH------E 250

  Fly   611 TIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLP--KHQEVKRRFLEICD 673
            |.:              ||.||:.         :|::..| .|..:.:.  ..|....|.|: .|
 Worm   251 TPV--------------DLLRKIS---------VSRKESG-THVDTVVTTIDGQRYDTRELD-TD 290

  Fly   674 TTFSEEVRAALRLPAFD-SYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEV 737
            ...:|  .|....|.|. |.:.....:..|...:|.:......|.:.......:.:.:.|.|.|:
 Worm   291 PDLAE--TAVWSFPIFQMSRKHPQTILSRLTYNIFQQAELFRIFKVSPIKFFNFFHALEKGYWEI 353

  Fly   738 PFHNFRHCFCVAQMMYAIT-------------------------RQANLLSRLGDLECLILLVSC 777
            |:||..|...|....|.::                         :.::::|:|..||.:.|..:.
 Worm   354 PYHNRIHAADVLHGCYYLSAHPVRSTFLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAA 418

  Fly   778 ICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIRE 842
            ..||.||||..|.:.:....:.|:.|||.|.|||||.:.:::||..||.:..:|.........|.
 Worm   419 AMHDYDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRY 483

  Fly   843 GIIRCILATDMARHNEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDR 907
            .::..|||||:.:|.||:..|.|.....|........|:..:|||:|||::..:|..:...|.||
 Worm   484 LVLEYILATDLKQHFEIIMTFTERLTEIDVQVETDRLLIGKLLIKMADINSPTKPYGLHRQWTDR 548

  Fly   908 LLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGE--LVPELTELIIIP 970
            :.:||:.|...|:..|||:||:||.........|..||..|:.||..|:.|  |:|.|..|....
 Worm   549 ICEEFYEQGDDERRRGLPITPYMDRGDAQVAKLQDSFIAHVVSPLATAMNECGLLPILPGLDTSE 613

  Fly   971 VRIALEYYRRLNDAQTKTR-----------------KSVADSNTSATSDS----NSGTIDSNAAM 1014
            :.|.:|:..|....|.:..                 ..|.:..:::||||    ....:||:.:.
 Worm   614 LIINMEHNHRKWKEQIELENGGSYEAQITCNGGTAVNGVIEEESASTSDSPDPRRDSPLDSDLSQ 678

  Fly  1015 V 1015
            |
 Worm   679 V 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	77/254 (30%)
pde-3	NP_001293571.1	PDEase_I	355..606	CDD:459723	76/250 (30%)