Protein Alignment Pde9 and pde-4

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_871945.1
• Gene: pde-4 / 174235
• WormBaseID: WBGene00020114
• Length: 674
• Species: Caenorhabditis elegans
• Alignment Length: 777
• Identity: 164/777 - (21%)
• Similarity: 292/777 - (37%)
• Gaps: 224/777 - (28%)

  Fly   335 RRKSSSSSTISGTATVSGSVSVSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQ 399
            ||.|||||:.:|.:...|....|            :|..||                   |.|
 Worm     4 RRGSSSSSSAAGGSGGGGGFGFS------------SLRREL-------------------HLH-- 35

  Fly   400 HQQHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQPTSLPDG 464
                                    |....|:|:|::.:...|:...|.||..|        :| |
 Worm    36 ------------------------NFFRTSSPSASSTSRTPPAALPPRTSAVT--------IP-G 67

  Fly   465 SDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLL--AANSIANRATI 527
            |::   :..|..|:.....:     :|:...:.|.|    ..:.|..|.||.  .::|:..|...
 Worm    68 SNH---KLTSSASSYHPPRE-----LTVSTFSAGSA----TAADGLGGAHLTPSLSSSVHARRES 120

  Fly   528 ILSKSCSNVDGDATATAATALSSTVGGGIGGIGGSI------KMRASATDIETNALNGARDAIVA 586
            .|.::..:: .:|::....:.:|::.....|.|..:      ::.||..::.:|        :::
 Worm   121 FLYRASDDL-REASSLRPVSRASSIASNEHGHGDDLIVTPFAQLLASLRNVRSN--------LIS 176

  Fly   587 SNNGNNGNNGNNGNNE-----YSILQLNNTIIQC-HFNDDDFRALVKDLKRKVEYTERMNWLCLS 645
            ..|..|.::..:.|..     ...::|.:.::.| |                 :..|.::| ||.
 Worm   177 ITNIQNSDDSRHANRSAKRPPLHNIELPDDVVHCAH-----------------DTLEELDW-CLD 223

  Fly   646 KRPLGPPHRKSSLPKHQEVKR-------RFLE----------ICDTTFSE--------------E 679
            :......||..|.....:.::       .|.|          ...||:.:              |
 Worm   224 QLETIQTHRSVSEMASSKFRKMLNKELSHFAESSKSGTQVSKFLITTYMDKEEDEPSIEIEVPTE 288

  Fly   680 VRA---------------------------ALRLPAFDSY--------------------EWSDA 697
            |:.                           .||.|:.|.:                    :|. .
 Worm   289 VQGPSTSGPMTLSILKKAQTAAMNKISGVRKLRAPSHDGHVPEYGVNCAREIAVHMQRLDDWG-P 352

  Fly   698 DVIHLMQ------------TMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQ 750
            ||..:.:            ::..:....:.|.|...||..:|..:..||....:|||.|...|||
 Worm   353 DVFKIDELSKNHSLTVVTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHYRNNHYHNFIHAADVAQ 417

  Fly   751 MMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCS 815
            .|:.:.....|.....|||.|..:.:...||:||||:.|.|.||:..|||:.|||.|.||.||.:
 Worm   418 SMHVLLMSPVLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLA 482

  Fly   816 IAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITP----------IF 870
            :||:||:...|:...|.||......|:.:|..:|||||::|..:|.....:..          :.
 Worm   483 VAFKLLQDSNCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVL 547

  Fly   871 D-YSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDK 934
            | |:::..:   ...:|.:||:||..:|:::.:.|..|:::|::.|...||..||.::|..|...
 Worm   548 DKYNDKIQV---LQSMIHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGN 609

  Fly   935 VSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSN 996
            |:...|||.||..::.||:|...:||....:.|:..:....|:|:.....:..|.::|.:.:
 Worm   610 VTIEKSQVGFIDYIVHPLYETWADLVYPDAQNILDQLEENREWYQSRIPEEPDTARTVTEDD 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	80/238 (34%)
pde-4	NP_871945.1	PDE4_UCR	157..273	CDD:465648	20/141 (14%)
		PDEase_I	406..646	CDD:459723	81/242 (33%)