Protein Alignment Pde9 and pde-1

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: NP_493343.1
• Gene: pde-1 / 173200
• WormBaseID: WBGene00011433
• Length: 664
• Species: Caenorhabditis elegans
• Alignment Length: 668
• Identity: 165/668 - (24%)
• Similarity: 268/668 - (40%)
• Gaps: 186/668 - (27%)

  Fly   469 RRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSI---------ANR 524
            |.|:.|.|...::|.     |: ||.:. ..|...|    |.:.:.||:...|         ::|
 Worm     3 RARKTSSCGCFRSAF-----CL-LKPST-SSASEEH----GDSDKKLLSVQLITPRDEEEQTSSR 56

  Fly   525 ATIILSKSCSNVDGDATATAATALS---STVGGGIGGIGGSIKMRASATDIETNALNGARDAIVA 586
            :..|.....:.:|....|.||....   ::.|||:.|.|...::          .|:|.:..:..
 Worm    57 SIKIPPLDLNGLDCKKNAVAARRAGRRRTSEGGGVRGKGHFAEV----------VLDGLQRPVSL 111

  Fly   587 SNNGNNGNNGNNGNNE---------------------------YSILQLNNTIIQCHFNDDDFRA 624
            ..|....:|.::...|                           |.:.|||:..:.
 Worm   112 LRNQKEKSNSDDNCQEKEPTSPSSSRKKSYDNAPALESLEKLRYILHQLNSGQLP---------- 166

  Fly   625 LVKDLKRKVEY------------TERM--------------------NWLC--LSKRPLGPPHRK 655
             ::||||.:||            |.|:                    .||.  .:::..|   :|
 Worm   167 -LEDLKRNIEYAALVLETAYMDETRRICDEDDDLAEVTPETVPDEVREWLAATFTRQNAG---KK 227

  Fly   656 SSLPKHQ----------------------------EVKRRFLEICDTTFS----EEVRA--ALRL 686
            ...||.:                            |:.....|:|..:||    .||..  ||:.
 Worm   228 RDKPKFKSVANAIRTGIFFEKLFRKQQVVQCPIPPEIAELMKEVCTWSFSPFQLNEVSEGHALKY 292

  Fly   687 PAFDSYEWSDADVIHLMQTMFVELGFIEKFSIPVDTLREWL--YEV-YKHYNEVPFHNFRHCFCV 748
            ..|:               :|...||:::|.:|:..|..:|  .|| |..:|. |:||..|...|
 Worm   293 VGFE---------------LFNRYGFMDRFKVPLTALENYLSALEVGYSKHNN-PYHNVVHAADV 341

  Fly   749 AQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHH 813
            .|..:.:..|..|.:.|||||.|.:|...:.||.:|.|:.|.:.|.::::.|:.|||.|.|||||
 Worm   342 TQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQFAMLYNDRSVLENHH 406

  Fly   814 CSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDY------ 872
            .|..|||::..:.||..:.:||.:..:|..:|..:|||||:.|      ||:|..:...
 Worm   407 VSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTH------FMQIKTMKSMLSLPEG 465

  Fly   873 --SNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKV 935
              .|:|    ||:| :...|||:.|:|.::.|.|.:.:|:|||.|...|.|.|||.:|..|...|
 Worm   466 IDKNKA----LCLI-VHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASMGLPYSPLCDRHTV 525

  Fly   936 SKPGSQVRFIGLVLLPLFEALGELVPELTE-LIIIPVRIALEYYRRLNDAQTKTRKS----VADS 995
            ....||:.||..::.|.....|||:.::.| |:.:|...:| :...::....|:..:    :.|.
 Worm   526 HVADSQIGFIDFIVEPTMVVCGELLVKMVEPLVSLPPTDSL-FPPSVDGGDDKSPSNALSPLPDL 589

  Fly   996 NTSATSDSNSGTIDSNAA 1013
            ..|:||.|:...|..|.|
 Worm   590 RNSSTSPSSIRRIPLNYA 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	83/236 (35%)
pde-1	NP_493343.1	PDEase_I_N	191..248	CDD:462497	7/59 (12%)
		PDEase_I	332..560	CDD:459723	84/238 (35%)