DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pde9 and Pde11a

DIOPT Version :10

Sequence 1:NP_727644.3 Gene:Pde9 / 32233 FlyBaseID:FBgn0259171 Length:1623 Species:Drosophila melanogaster
Sequence 2:NP_543169.1 Gene:Pde11a / 140928 RGDID:621793 Length:935 Species:Rattus norvegicus


Alignment Length:977 Identity:203/977 - (20%)
Similarity:352/977 - (36%) Gaps:278/977 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 QTTAQEGTSPSGGSSSSGNA-------------VLL-------QRSSNNLQQQQQQQQQQQQHLQ 169
            |::|:..|...||:...|:|             |.|       .|...|||::..|::       
  Rat    63 QSSARGSTGIGGGAGPQGSANSHPASGGGESAGVPLSPSWASGSRGDGNLQRRASQKE------- 120

  Fly   170 LQLQQADERLLRKIGYIASRVRCLSKYYGD---FRLVNPYSARRQRRQLQEILLRHSIFDPGKEH 231
                      ||| .:..|:...:::.|.:   .|...|.|:.|:|    .:|.:.|...|...|
  Rat   121 ----------LRK-SFARSKAIHVNRTYDEQVTSRAQEPLSSVRRR----ALLRKASSLPPTTAH 170

  Fly   232 QRAIVLAAATAAIAGPLAAIDCVC-----GSSSISLEAVSSRSRSSEL---------------ED 276
            ..:.:|.:.......|..|||..|     ......||.|...|...:|               :.
  Rat   171 ILSALLESRVNLPQYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDA 235

  Fly   277 DHHEQDQVQEEQEQEQ---------HQG------DTEDNEEEQEHP---------SEKPERTDI- 316
            |......|:.....::         |.|      .|.:|..|.:.|         .|..|..:| 
  Rat   236 DRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSTTENSNEVQVPWGKGIIGYVGEHGETVNIP 300

  Fly   317 --------EEEPPPAIAVTTTTTATVRRKSSSSSTISGTATVSGSVSVSASASQS---------- 363
                    .:|........|.:...:..::|....| |.|.....|...|..::.          
  Rat   301 DAYQDRRFNDEIDKLTGYKTKSLLCMPIRNSDGEII-GVAQAINKVPEGAPFTEDDEKVMQMYLP 364

  Fly   364 FCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCN--SIQNNN 426
            ||...|:..:.......|.:..|:.|.|:.....:|....:..::|.:.......|.  |:....
  Rat   365 FCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE 429

  Fly   427 NMSNP---------------AATAAATATPSVEQPATS------------GTTNIHLQPTSLPDG 464
            ::.:|               :|.|..:...|||:.:.|            .:|.:   |.::.|.
  Rat   430 DIESPVVKFTKSFELMSPKCSADAENSFKESVEKSSYSDWLINNSIAELVASTGL---PVNVSDA 491

  Fly   465 SDNPRRRRASDCSAVQAA---LQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRAT 526
            ..:||    .|..|.|.:   :::.| |:.:.|:|                ..::....:.||  
  Rat   492 YQDPR----FDAEADQISGFHIRSVL-CVPIWNSN----------------HQIIGVAQVLNR-- 533

  Fly   527 IILSKSCSNVDG----DATATAATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVAS 587
                     :||    ||......|.....|.||                               
  Rat   534 ---------LDGKPFDDADQRLFEAFVIFCGLGI------------------------------- 558

  Fly   588 NNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPP 652
                                 ||||:        :..:.|...::....:.:::.....:.....
  Rat   559 ---------------------NNTIM--------YDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594

  Fly   653 HRKSSLPKHQEVKRRFLEICDTTFSE-------EVRAALRLPAFDSYEWSDADVIHLMQTMFVEL 710
            .:.:::|...|     |.|.|..|.:       .:.||||                    ||:||
  Rat   595 FKAANIPLVSE-----LAIDDIHFDDFSLDVDAMITAALR--------------------MFMEL 634

  Fly   711 GFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLV 775
            |.::||.|..:||..||..|.|:|..|.:||:||.|.|.|:|:|:...|.....|.::|.|.::|
  Rat   635 GMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIV 699

  Fly   776 SCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNI 840
            .|:||||||.|.||.:|..:.:.||..|...:.||:||.:.|..:|:....|||.|.|...::::
  Rat   700 GCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDL 764

  Fly   841 REGIIRCILATDMARHNEILTQFMEITP--IFDYSNRAHINLLCMILIKVADISNEARPMDVAEP 903
            .:.:.:.|||||:..:.|..|:|.|:..  .:|:|..:|.::...:|:...|:....:|.:::..
  Rat   765 MQLLKQSILATDLTLYFERRTEFFELVSKGAYDWSITSHRDVFRSMLMTACDLGAVTKPWEISRQ 829

  Fly   904 WLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSK---PGSQVRFIGLVLLPLFEALGELVPELTE 965
            ..:.:..|||.|...|:|| |.:||....|:..|   |..|:.:|..:.:||::||.::..:|..
  Rat   830 VAELVTSEFFEQGDRERSE-LKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNAKLKP 893

  Fly   966 LI 967
            ::
  Rat   894 ML 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde9NP_727644.3 PDEase_I 739..967 CDD:459723 74/232 (32%)
Pde11aNP_543169.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 41..125 17/79 (22%)
GAF 217..380 CDD:214500 23/163 (14%)
GAF 402..568 CDD:214500 36/260 (14%)
PDEase_I 663..898 CDD:459723 74/234 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 915..935
Blue background indicates that the domain is not in the aligned region.

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