Protein Alignment Pde9 and LOC1273035

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_311976.5
• Gene: LOC1273035 / 1273035
• VectorBaseID: AGAMI1_012236
• Length: 1494
• Species: Anopheles gambiae
• Alignment Length: 1532
• Identity: 616/1532 - (40%)
• Similarity: 780/1532 - (50%)
• Gaps: 349/1532 - (22%)

  Fly   176 DERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRRQLQEILLRHSIFDPGKEHQRAIVLAAA 240
            |.:||..:||||.|:|.|                .|:..|.|:          |:..|.|||
Mosquito     9 DVKLLADLGYIADRLRNL----------------EQKWDLTEL----------KDLHRRIVL--- 44

  Fly   241 TAAIAGPLAAIDCVCGSSSISLEAVSSRSRSSELEDDHHEQDQVQEEQEQEQHQGDTEDNEEEQE 305
              .:..|...:          |....:.:|:..:.....:|...||.||:.     ....||:::
Mosquito    45 --KLDDPPTNV----------LRLRETLARTPTVPPGSPDQQYQQEGQEEL-----ANCTEEQED 92

  Fly   306 HPSEKPERTDIEEEPPPAIAV-----TTTTTATVRR---KSSSSSTISGTATVSGSVSVSASASQ 362
            ...:.|.....:|..||::.|     .:..:.|..|   :|..||....:....|:|..|.
Mosquito    93 TGLQLPVVIIADEVTPPSVIVEECAEASEVSPTADRGDDESGESSNQRNSVEDVGNVEESV---- 153

  Fly   363 SFCSNNINLLEELLIQFYEEQDHRSN----------LTVIR------------------------ 393
                ..::.||||:|.||.....||:          ...:|
Mosquito   154 ----RKLDQLEELVIAFYHSCGRRSSRGGADTEQTASEAVRDGASRARAKRTKKRQQQSSGEACT 214

  Fly   394 --HHHHQQHQ-QHQQQQRITNNNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIH 455
              :|..|||| :|....|..|...:.:     |:.:::::  |.||||:.||......:|.....
Mosquito   215 GAYHPDQQHQKRHPDPDRTMNQGTDPD-----QDRDHLAH--AAAAATSAPSDTSVVPAGDGRQQ 272

  Fly   456 LQPTSLPD-GSDNPRRRRASDCSAVQAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAAN 519
            .||..|.. .:|.|....:.|   ....|.::...:||......:...........|.|..:.|
Mosquito   273 AQPQPLRSIHADAPEPGHSLD---RDVPLDDEEDTVTLTAETSSECCSQQTVVAVVAEEEEVEA- 333

  Fly   520 SIANRATIILSKSCSNVDGDATATAATALSSTVGGGI-----GGIGGSIKMRASATDIETNALNG 579
                :|..::... |:...|.|.|.|....:|....:     ||........|...|..|.....
Mosquito   334 ----QAEEVVEDG-SSPGHDPTETVAPGSDTTTDDEVENDDTGGSDADANDEAEPGDTCTRRTVL 393

  Fly   580 ARDAIVASNN---GNNGNNGNNGNNEYSILQLNNTIIQ-------C----HFNDDDFRALVKDLK 630
            .:|:..:|..   |.......|......:.:|.|....       |    :..|:|.:.||::||
Mosquito   394 GQDSTPSSRRCSLGGEFETEQNRRLRRRLSELTNNFCTPKQFQQLCDNLDNITDNDLKLLVRELK 458

  Fly   631 RKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDTTFSEEVRAALRLPAFDSYEWS 695
            ||:|:.|||||||||.||.||||||:|||||.:||:||||.||.|.|:||:|||||||||||||.
Mosquito   459 RKIEFAERMNWLCLSSRPRGPPHRKTSLPKHTDVKKRFLETCDKTLSDEVKAALRLPAFDSYEWE 523

  Fly   696 DADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQAN 760
            |.|||||||||||||..:|||:||:.||||||||||||||:|||||:|||||||||||.|....|
Mosquito   524 DWDVIHLMQTMFVELNLLEKFNIPIVTLREWLYEVYKHYNDVPFHNYRHCFCVAQMMYTIAWHTN 588

  Fly   761 LLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPE 825
            |:.|||:||.|:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   589 LVQRLGELEVLVLLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPE 653

  Fly   826 CNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHINLLCMILIKVAD 890
            ||||:|.|::.:.::|||||||||||||||||||||||.|.||.|||||:.|.|||||:||||||
Mosquito   654 CNIFRNMSKEMYKDVREGIIRCILATDMARHNEILTQFQEATPEFDYSNKVHTNLLCMVLIKVAD 718

  Fly   891 ISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEA 955
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   719 ISNEARPMDVAEPWVDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEA 783

  Fly   956 LGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTIDSNAAMVSTPGG 1020
            ||||:||||:|||.|||:||:||||||||..|||:|:|::..:
Mosquito   784 LGELLPELTDLIITPVRVALDYYRRLNDAANKTRRSIAEAEAA---------------------- 826

  Fly  1021 ASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIP 1085
                         |..|||                          |||:|||.||||||||||||
Mosquito   827 -------------SSESGG--------------------------SPQLPRSQSGISVKSRRSIP 852

  Fly  1086 SQKSASRTSVDEPGGMASELHDLPEGSESGDSETATEVDVAEKTSKFKVDTEGSSNRSKSSHSTS 1150
            |||||||||||||..:|:||||||||||||||||||||||||||||||||||  |...|.||..|
Mosquito   853 SQKSASRTSVDEPILIAAELHDLPEGSESGDSETATEVDVAEKTSKFKVDTE--SIHRKQSHPNS 915

  Fly  1151 RKSSREKRPSMIGELCSSGGGQRIRNSYGNIHGYHSNRCHFGNNRAVSLDQYSSAGNNRRLSDGL 1215
            ||.|||||||||||..::  |.|.|.|:|||. :.:||.:||:|||:||||||   ||||:|||:
Mosquito   916 RKGSREKRPSMIGEYYTT--GTRTRGSHGNIQ-HTNNRTYFGSNRAISLDQYS---NNRRMSDGV 974

  Fly  1216 P--QVISDSNVFYGRH---NRSSTETTVAVGNPQDTNANTNHPVGCQLKELLARTEADSDGEGDG 1275
            |  .|.||::|.|..|   :||....|:...:.:.|:.|:.|               |:...||
Mosquito   975 PIQSVHSDNSVLYYHHQRQHRSLDHDTMCSSSDKSTSLNSTH---------------DTAPGGD- 1023

  Fly  1276 NGREDKKIPLVIPSMP--------------QLATSSNGNISPTLVVTEQILPSNGSTRSSASSGR 1326
                    |..|..:|              :|..||:.:.|........:..:|.:.....|:..
Mosquito  1024 --------PTTILHVPPPQPPPPTGKQRLGKLFGSSSASGSAATSAVANLKNNNSAGHGCTSTAV 1080

  Fly  1327 GGSGVPGGSGGSGMPGPSAGSGSSWKSRLRQFSDYFSFS----FDK----SNKRFGSTRSSPCPG 1383
            |||....|.||.|     ||         :.||...||:    .||    :|.:..:..::...|
Mosquito  1081 GGSASTSGGGGGG-----AG---------KHFSRMLSFNQQQRLDKLRNNNNSQSKNNNNNNNNG 1131

  Fly  1384 SNSSSGRTNNNANGLGENQ--------------------DGLGAGGGIKPGMCCTTITNSSG--- 1425
            ..||.|.:|||.|....|.                    ||..|..|  .|..|..:.:::|
Mosquito  1132 GGSSIGNSNNNNNNNNNNSISNNKNAPAGSAAISHAKHLDGREAMHG--AGRMCPGLGSAAGGDG 1194

  Fly  1426 ---STVKGETRGGTAGAG------GG---------------ALTTMTTGNDAH-QRHRAYSLDVP 1465
               .|:.|...||..|.|      ||               |.:|.:.|:.:. .|.|.::
Mosquito  1195 GFDGTISGSVGGGGVGGGNQDGGKGGNGSSSNGTAARTTAAAASTASAGSKSFLSRLRQFT---- 1255

  Fly  1466 GMMRYSSNDSSRHPSNNTLQSAGGGA-------GLTTGLEVTAQRVPPSLSVEMGLASGSSSEAG 1523
              .|.|.|..||  .:..||...|.|       |.:.|.: ...|:..|.:|::|       :.|
Mosquito  1256 --GRLSFNFDSR--ESKKLQLLAGNAPTDLKAKGASAGPK-RDHRLEKSRTVDVG-------DLG 1308

  Fly  1524 PKIXQQGSTRQDAVAISKGYDGAVEQQEEEEEEEDEQ 1560
            |......||       ..|...|:..|:::::.:.:|
Mosquito  1309 PVAICGDST-------MSGQQAAIHHQQQQQQHQKQQ 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	197/227 (87%)
LOC1273035	XP_311976.5	PDEase_I	567..795	CDD:459723	197/227 (87%)