DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and PDE10A

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	NP_001372008.1	Gene:	PDE10A / 10846	HGNCID:	8772	Length:	1055	Species:	Homo sapiens

Alignment Length:	290	Identity:	86/290 - (29%)
Similarity:	145/290 - (50%)	Gaps:	12/290 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   720 VDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDH 784
            ::.|..::..|.|:|..||:||::|...||..||||.:..:.|  ..|||...||::|:||||||
Human   771 LEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTL--FTDLERKGLLIACLCHDLDH 833

  Fly   785 PGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCIL 849
            .|::|.|.......||..|: .|.:|.||.|....:|:....|||...|...:..:.|.|.:.|:
Human   834 RGFSNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAII 897

  Fly   850 ATDMARH--NEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEF 912
            |||:|.:  |....:.|..|...:.:|::|.:.:..:::...|:.:..:...|.:...:.:..||
Human   898 ATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF 962

  Fly   913 FAQSAAEKSEGLPVTPFMDPDKVSK-PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALE 976
            :|:....|..|:...|.||.||..: |..|:.|...|.:|.:..|.:::|. ||.::...|..|.
Human   963 WAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPP-TEPLLKACRDNLS 1026

  Fly   977 YYRR-LNDAQTKT---RKSVADSNTSATSD 1002
            .:.: :...:|.|   ..||| ...:|:.|
Human  1027 QWEKVIRGEETATWISSPSVA-QKAAASED 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	71/230 (31%)
PDE10A	NP_001372008.1	GAF	367..510	CDD:396252
		GAF	543..698	CDD:214500
		PDEase_I	790..1022	CDD:395177	71/235 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820