DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and pde1ca

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_021326050.1	Gene:	pde1ca / 101883995	ZFINID:	ZDB-GENE-111215-4	Length:	777	Species:	Danio rerio

Alignment Length:	687	Identity:	162/687 - (23%)
Similarity:	266/687 - (38%)	Gaps:	189/687 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   624 ALVKDLKRKVEY------------TERM--------------------NWLCLS-KRPLGPPHRK 655
            |.|.|||:.:||            |.|:                    :||..: .|.:|...|:
Zfish   116 ASVVDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRR 180

  Fly   656 S-SLPKHQEV-------------KRRFLEICDTTFSEEVRAALR---LPAFDSYEWSDADVIHLM 703
            | ..|:.:.:             .||...:...::...|..||:   ..:||.:..:||...|.:
Zfish   181 SEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVITALKHVDTWSFDVFTLNDASGDHSL 245

  Fly   704 QTMFVEL----GFIEKFSIPVDTLREWL--YEV-Y-KHYNEVPFHNFRHCFCVAQMMYAITRQAN 760
            :.:|.||    ..|.:|.|||..|..::  .|| | ||.|  |:||..|...|.|.::.:..:..
Zfish   246 KFIFYELLTRYDLINRFKIPVSALVSFVEALEVGYGKHRN--PYHNLIHAADVTQTVHYLLLKTG 308

  Fly   761 LLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLL-EHP 824
            ::..|.:||...:|.:...||.:|.|..|.:.|..|::.|:.|||.:..||||.|.|:||| |..
Zfish   309 MVHWLTELEIFAMLFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRAVQENHHVSAAYRLLQEDD 373

  Fly   825 ECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHINLL-------- 881
            |.||..|.|:|.:..:|..::..:|||||:.|      |.:|        :|..|.|
Zfish   374 EMNILYNLSKDDWRELRTLVVEMVLATDMSCH------FQQI--------KAMKNFLQQPEGIDK 424

  Fly   882 ---CMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVR 943
               ..:|:..||||:.|:..::...|...||:|||.|...|...|||.:|..|........||:.
Zfish   425 PKALSLLLHTADISHPAKNWNMHYRWTTSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIG 489

  Fly   944 FIGLVLLPLFEALGELVPE-LTELIIIPVRIALEYYRR--LND-----AQTKTRKSVADSNTSAT 1000
            ||..::.|.|..|.:::.: :|.||.......|..:||  ||:     .::..|.:.::..||..
Zfish   490 FIDFIVEPTFTVLTDMIEKIMTPLIEEASPAGLAGFRRSSLNNIPSDGKRSSVRSTGSEGGTSVN 554

  Fly  1001 SDSNS-----------------------------------GTIDSNAAMVSTPGGASDKLSLDKG 1030
            |..|:                                   ..::.|.....|...:||..:..:.
Zfish   555 SSINAVDFKTFKSTWNEEVHKNREKWKAQAAKDLEEKAKQEEMEENEKKKDTDTQSSDDNTKTED 619

  Fly  1031 QGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKSASRTSV 1095
            :.|:.                       |||.   ||...:..:.   ..:.|...|:.:.:..|
Zfish   620 KINTD-----------------------SNAK---SPDKQKEDTR---PEKDSKTDQEDSGKAKV 655

  Fly  1096 D----------------EPGGMASELHDLPEGSESGDSETATEVDVAEKT---SKFKVDTEGSSN 1141
            |                :||||    :.....|:..:.||:::.|.:::.   |:.....:...:
Zfish   656 DNKEPTEQQPREKEGNKDPGGM----NGAQTPSDGKEPETSSDTDNSQRVHNGSEELNSPDSDDS 716

  Fly  1142 RSKSSHSTSRKSSREKRPSMIGELCSSGGGQRIRNSY 1178
            .||.|:.::|:.....|.|.....|:        |||
Zfish   717 ESKRSYVSTRRKYHLVRYSKKPSYCA--------NSY 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	75/240 (31%)
pde1ca	XP_021326050.1	PDEase_I_N	146..202	CDD:312112	7/55 (13%)
		PDEase_I	287..513	CDD:306695	75/239 (31%)
		COG3942	584..>760	CDD:332523	33/203 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010