Protein Alignment Pde9 and pde3a

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_031753954.1
• Gene: pde3a / 101730602
• XenbaseID: XB-GENE-6033578
• Length: 1022
• Species: Xenopus tropicalis
• Alignment Length: 790
• Identity: 166/790 - (21%)
• Similarity: 282/790 - (35%)
• Gaps: 209/790 - (26%)

  Fly   303 EQEHPSEKPERTDIEEEPPPAIAVTTTTTATVRRKSS---SSSTISGTATV---------SGSVS 355
            :.|..||:.|:..|     |.....:..|..:||.||   ::::.:|..|:         |||:.
 Frog   290 DSEEGSERGEKLTI-----PKRLRKSLPTGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSGSIK 349

  Fly   356 VSASASQSFCSNNINLLEELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITNNNNNNNNCN 420
            ...|:|.   ||..:....||::........:|         ..|...:.:|.|..|
 Frog   350 PLDSSSS---SNPDSWHNSLLLKSRPFSPSLAN---------TNHVTPKWRQGIPPN-------- 394

  Fly   421 SIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQPTSLPDGSD------NPRRRRASDCSAV 479
                    .:|..:...:..|..  ||.|.|  :...|....||::      ||.:..:|..||.
 Frog   395 --------ISPLISPCQSPIPGT--PAASPT--VKSLPVQFCDGTELGRLGPNPHKVLSSTKSAP 447

  Fly   480 QAALQNQLHCITLKNNNCGKAMPFHRGSCGAAGEHLLAANSIANRATIILSKSCSNVDGDATATA 544
            :  :.......||...:||::......|.||     |....:.:........:.:..|.|:|...
 Frog   448 E--IPEPFPGSTLVCASCGRSYSPVNPSDGA-----LDPGEVPHSQNRTDDPTHTTSDYDSTHET 505

  Fly   545 ATALSSTVGGGIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLN 609
            ..:.||.:                   :.::..:||:|...:..:
 Frog   506 NHSDSSDI-------------------LPSDEPDGAKDPAQSRKS-------------------- 531

  Fly   610 NTIIQCHFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGPPHRKSSLPKHQEVKRRFLEICDT 674
                ...|..:....|:...::.|          |:..||                  .:|..|:
 Frog   532 ----SASFQGEVLHPLIHSEEKAV----------LAPEPL------------------LMEDLDS 564

  Fly   675 TFSEEVRAALRLPAFDSYEWSDADVIHLMQ----TMFVELGFIEKFSIPVDTLREWLYEVYKHYN 735
            ...|...  ...|.||..|.:......::.    .:|.::|.:|.|.||:.....:.:.:...|.
 Frog   565 LMGEINN--WNFPIFDLVEKTGQKTGRILSQVSYRLFEDMGLLETFKIPLREFMNYFHALESGYR 627

  Fly   736 EVPFHNFRHCFCVAQMMYAITRQA-----NLLSRLG----------------------------- 766
            ::|:||..|...|...::.::.||     |.:|..|
 Frog   628 DIPYHNRIHATDVLHAVWYLSTQAIPGLPNAVSEQGSASDSDSDSGITHGHMGYVFSKMYNPSDD 692

  Fly   767 ----------DLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRL- 820
                      .||.:.|.|:...||.||||..|.:.:......|:.|||.|.|||||.:.|:.|
 Frog   693 TYGCLSGNIPSLELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAAAAWNLF 757

  Fly   821 LEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFM-----EITPIFDYSNRAHINL 880
            |..||.|...|.....|...|..:|..|||||:.:|.:.|.:|.     |::|..|:||.....|
 Frog   758 LSRPEYNFLVNLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKVNGEVSPGIDWSNENDRLL 822

  Fly   881 LCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFI 945
            :|.:.||:|||:..|:..|:...|.:.::.||:.|...|.|.|||::||||.........|..||
 Frog   823 VCQMCIKLADINGPAKFKDLHLKWTEGIVNEFYEQGDEESSLGLPISPFMDRSAPQLAKLQESFI 887

  Fly   946 GLVLLPL---FEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGT 1007
            ..::.||   :::.| |:|.                :.|:::..:......|......::..|..
 Frog   888 THIVGPLCHSYDSAG-LMPG----------------KWLDESDERDESDDTDEQEEEDTEEESSE 935

  Fly  1008 IDSNAAMVST 1017
            .:.:.|.:|:
 Frog   936 PNESLASMSS 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	83/280 (30%)
pde3a	XP_031753954.1	PRK07764	<19..209	CDD:236090
		PDEase_I	631..894	CDD:459723	78/262 (30%)