DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and pde1cb

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_017207862.1	Gene:	pde1cb / 100536162	ZFINID:	ZDB-GENE-090902-2	Length:	698	Species:	Danio rerio

Alignment Length:	781	Identity:	181/781 - (23%)
Similarity:	309/781 - (39%)	Gaps:	178/781 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 AATAAATATPSVEQPATSGTTNIHLQPTSL---PDGSDNPRRRRASDCSAVQAALQNQLHCITLK 493
            |..|..|:..|:.| .|:|::..:...|:.   .||..|.|.......|..|:||.|.|...|.|
Zfish    35 AVRAKHTSRQSLAQ-KTTGSSRANTPQTATVANEDGETNSRPLARFARSKSQSALWNTLTAGTSK 98

  Fly   494 NNNCGKA---MPFHRGSCGAAGEHLLAANSIANRATIILSKSCSNVD-GDATATAATALSSTVGG 554
            ... |||   :|                 ....|...||:....:.| .:||...|..|...|..
Zfish    99 KEK-GKAQRDVP-----------------DDPQRIEEILADELPSTDTPEATEKTAVRLRCLVKQ 145

  Fly   555 GIGGIGGSIKMRASATDIETNALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFND 619
            ...|       .||..|::.|.                         ||:...|.:..|
Zfish   146 LERG-------EASLVDLKKNL-------------------------EYAATVLESVYI------ 172

  Fly   620 DDFRALV------KDLKRKVEYTERMNWLCLS-KRPLGPPHRKS-SLPKHQEV------------ 664
            ::.|.||      .|::.....:|..:||..: .|.:|...|:: ..|:.:.:
Zfish   173 EETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRTEEKPRFRSIVHAVQAGIFVER 237

  Fly   665 -KRRFLEICDTTFSEEVRAALRLP---AFDSYEWSDADVIHLMQTMFVEL----GFIEKFSIPVD 721
             .||...:...::...|.|.|:..   :||.:..:::...|.::.:|.||    ..|.:|.|||.
Zfish   238 MYRRTSNMVGLSYPPNVIAVLKNVDRWSFDVFALNESSGDHALKFIFYELLTRYDLISRFKIPVS 302

  Fly   722 TLREWL------YEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICH 780
            .|..::      |..||:    |:||..|...|.|.::.:..:..::..:.:||...::.:...|
Zfish   303 ALVSFVEALEVGYSKYKN----PYHNLIHAADVTQTVHYLLLKTGMVHWMTELEIFAMIFAAAIH 363

  Fly   781 DLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLL-EHPECNIFKNFSRDTFNNIREGI 844
            |.:|.|..|.:.|..|::.|:.|||.|.||:||.|.::||| :..|.||..|.|:|.:...|..:
Zfish   364 DYEHTGTTNNFHIQTRSDAAILYNDRSVLESHHVSASYRLLQDDDEMNILYNLSKDDWREFRALV 428

  Fly   845 IRCILATDMARHNEILTQFMEITPIFDYSNRAH-------INLLCMILIKVADISNEARPMDVAE 902
            :..:|||||:.|      |.::..:.:|..:..       |:|    |:..||||:.|:..|:..
Zfish   429 VEMVLATDMSCH------FQQVKAMKNYLQQPEGIDKPKAISL----LLHAADISHPAKTWDLHH 483

  Fly   903 PWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELI 967
            .|...||:|||.|...|...|||.:|..|........||:.||..:::|.|..|    .::||.|
Zfish   484 RWTTSLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVL----TDMTEKI 544

  Fly   968 IIPV-----RIALEYYRRLNDAQTKTRKSVADSNTSATSDSNSG---TIDSNAAMVSTPGGASDK 1024
            :.|:     ...|..:|.:.....|  :|..:|:.|.:|.|::|   |:|    :.:.....:::
Zfish   545 VTPLIEEATSSGLSGFRSITGGDVK--RSSVNSSASDSSSSHNGSLLTVD----LKNFKALWNEE 603

  Fly  1025 LSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKS 1089
            :||::.:...|                         ||.....:..|     .::.::.:.:|..
Zfish   604 VSLNRERWKMQ-------------------------AAKETEEKAKR-----ELEEQQEVENQVQ 638

  Fly  1090 ASRTSVDEPGGMASE---LHDLPEGSESGDSETATEVDVAEKTSKFKVDTEGSSNRSKSSHSTSR 1151
            .....:.||.....|   ::..||.|..|.|:.....:|:|       :.|..::..|.:.|.:.
Zfish   639 KKELELSEPKKDDPEPGVVNGPPEESPHGKSKKLQNGEVSE-------EAESPADEDKRTLSETA 696

  Fly  1152 K 1152
            |
Zfish   697 K 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	73/235 (31%)
pde1cb	XP_017207862.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920