DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde9 and pde8a

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_012814959.2	Gene:	pde8a / 100497070	XenbaseID:	XB-GENE-6051349	Length:	876	Species:	Xenopus tropicalis

Alignment Length:	1014	Identity:	218/1014 - (21%)
Similarity:	368/1014 - (36%)	Gaps:	277/1014 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 SNSDIEDSSPVESEDSEECEYIEIDCQTTAQEGTS-PSGGSSSSGNAVLLQRSSNNLQQQQQQQQ 162
            |:|.:...|..||:||....    ...|.||:|.| |.....||..:....|::::.:.:::...
Frog    10 SDSRVVYHSGKESDDSNSPH----QTNTLAQQGNSVPGLFIKSSHTSTYKVRANSSRKGRRENSP 70

  Fly   163 QQQQHLQLQLQQADERLLRKIGYIASRVRCLSKYYGDFRLVNPYSARRQRRQLQEILLRHSIFDP 227
            ..:..:......:...........|.:.......:|..:|        ::.|||.:|    :|..
Frog    71 SMEAEINSSTNSSTNSSTNSSTSTAVKAAVREVQFGPMKL--------RQDQLQVLL----VFAK 123

  Fly   228 GKEHQRAIVLAAATAAIAGPLAAIDCVCGSSSISLEAVSSRSRSSELE---DDHHEQDQVQEEQE 289
            ..........|...|.....:|                  |:..:.||   |.|||...:
Frog   124 EDSQSNGFCWACEKAGFKCNIA------------------RTPETALESFLDKHHEIIII----- 165

  Fly   290 QEQHQGDTEDNEEEQEHPSEKPERTDIEEEPPPAIAVTTTTTATVRRKSSSSSTISGTATVSGSV 354
                     |:...:...:|...|:....:|    :..|...|.|||:|....     |::...:
Frog   166 ---------DHRHSRYFDAEALCRSIRATKP----SENTVIVAVVRRQSDRDE-----ASIMPLI 212

  Fly   355 SVS------ASASQSFCSNNINLLE--ELLIQFYEEQDHRSNLTVIRHHHHQQHQQHQQQQRITN 411
            |..      .:::...|.|.:..||  |:|.|| :.:...|..|.:        ::.|:...||:
Frog   213 SAGFTRRYVENSNIMACYNELIQLEFGEVLAQF-KLRACNSLFTTL--------EKSQEAIEITS 268

  Fly   412 NNNNNNNCNSIQNNNNMSNPAATAAATATPSVEQPATSGTTNIHLQPTSLPDGSDNPRRRRASDC 476
            .:      :.||..|              |:.|  :|.|.....|....|   ::.|...:.||
Frog   269 ED------HIIQYVN--------------PAFE--STMGYQKDELIGKEL---TEVPINEKKSD- 307

  Fly   477 SAVQAALQNQLHCIT-----------LKNNNCG------KAMPF--HRGSCGAAGEHLLAAN--- 519
                  ..:.::|..           .||.|..      |.:|.  |||..    .|.::.:
Frog   308 ------FLDTINCCIKTGKEWEGIYYAKNKNGDNIQQNVKIIPVFGHRGKI----RHYVSISRPC 362

  Fly   520 SIANRATIILSKSCSNVDGDATATAATA-----------LSSTVGGGI--------GGIGGSIKM 565
            |..|:|    .|.|..|..::.....|.           :.||...|.        |.:.||.:.
Frog   363 SDNNKA----EKQCERVQAESQTDIQTCRHKDRRKGSLDVRSTTSRGSDGPAEFSHGALPGSSQR 423

  Fly   566 RAS------ATDIET------NALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQC--- 615
            |.|      :..||.      |.:|.|::                 |:...:.:..:.:::.
Frog   424 RHSSMARIHSMTIEAPITKVINIINAAQE-----------------NSPSPVAEALDRVLEILRT 471

  Fly   616 ---------------HFNDDDFRALVKDLKRKVEYTERMNWLCLSKRPLGP--PHRKSSLPKHQE 663
                           |.| |....|:.|..|::...|.:    ||.:.:.|  .|...:| ...:
Frog   472 TELYSPQLGTKDEDPHTN-DLVGGLMTDGLRRLSGNEYI----LSAKQVHPVSGHMILAL-SLSD 530

  Fly   664 VKRRFLEICDTTFSEEVRAALRLPAFDSYEWSDA----DVIHLMQTMFVELGFIEKFSIPVDTLR 724
            :..|..:..|.....|         ||.:|...|    .:::|...||...|..:..:....|||
Frog   531 IPPRIAQAMDNEEDWE---------FDIFELEAATHKRPLVYLGLKMFARFGVCQFLNCSEATLR 586

  Fly   725 EWLYEVYKHYNEV-PFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYN 788
            .||:.:..:|:.. .:||..|...|.........:..:...|..::.:..|::...||:||||..
Frog   587 SWLHVIESNYHSSNAYHNSTHSADVLHATAYFLCKERVKQSLDQIDEVAALIAATVHDVDHPGRT 651

  Fly   789 NIYQINARTELALRYNDISPLENHHCSIAFRLLEHPE-CNIFKNFSRDTFNNIREGIIRCILATD 852
            |.:..||.:|||:.|||.:.||:||.::||:|....: ||||||..|:.:..:|:.||..:|||:
Frog   652 NSFLCNAGSELAILYNDTAVLESHHAALAFQLTTRDDKCNIFKNMERNEYRTLRQAIIDMVLATE 716

  Fly   853 MARHNEILTQFME--------------------------ITPIFDYSNRAHINLLCMILIKVADI 891
            |.:|.|.:.:|:.                          .:|    .||.   |:..:|||.|||
Frog   717 MTKHFEHVNKFVNSINKPLAAVEENGGSIEEDEAVKNILTSP----ENRI---LIKRMLIKCADI 774

  Fly   892 SNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVT-PFMDPDKVSKPGSQVRFIGLVLLPLFEA 955
            ||..|.::....|..|:.:|:|||:..||.:||||. |..|.:..|.|.||:.|:...:..:|:|
Frog   775 SNPCRALEQCIEWAGRISEEYFAQTDEEKRKGLPVVMPVFDRNTCSIPKSQISFVDYFITDMFDA 839

  Fly   956 ------LGELVPELTELIIIPVRIALEYYRRLNDAQTKT 988
                  |..|:..|..        ..:|::.|::.|.||
Frog   840 WDAFADLPNLMQHLDN--------NFKYWKSLDERQLKT 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	82/261 (31%)
pde8a	XP_012814959.2	PDE8	1..48	CDD:400795	13/41 (32%)
		PAS	151..360	CDD:225112	53/276 (19%)
		PAS_9	262..360	CDD:404329	24/133 (18%)
		PDEase_I	602..854	CDD:395177	81/258 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010