Protein Alignment Pde9 and pde1c

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_031759760.1
• Gene: pde1c / 100495383
• XenbaseID: XB-GENE-994226
• Length: 762
• Species: Xenopus tropicalis
• Alignment Length: 632
• Identity: 155/632 - (24%)
• Similarity: 247/632 - (39%)
• Gaps: 148/632 - (23%)

  Fly   600 NNEYSILQLNNTIIQCHFNDDDFRAL-----VKDLKRKVEYTERMNWLCLS-KRPLGPPHRKSSL 658
            |.||:.     |:::..:.|:..|.|     :.|::.....:|..:||..: .|.:|      .:
 Frog   122 NLEYAA-----TVLESVYIDETRRLLDTEDELSDIQSDSVPSEVRDWLASTFTRQMG------MM 175

  Fly   659 PKHQEVKRRFLEICDTT----FSEEV------RAALRLP-------------AFDSYEWSDADVI 700
            .|..|.|.||..|....    |.|.:      ...|..|             :||.:..:||...
 Frog   176 LKRTEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIAVLKNVDKWSFDVFALNDASGD 240

  Fly   701 HLMQTMFVEL----GFIEKFSIPVDTLREWL--YEV--YKHYNEVPFHNFRHCFCVAQMMYAITR 757
            |.::.:|.||    ..|.:|.||:..|..::  .||  .||.|  |:||..|...|.|.::....
 Frog   241 HGLKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYTKHKN--PYHNLIHAADVTQTVHYFLF 303

  Fly   758 QANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLL- 821
            ::.|:..|.:||...::.:...||.:|.|..|.:.|..|::.|:.|||.|.|||||.|.|:|||
 Frog   304 KSGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQ 368

  Fly   822 EHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQFMEITPIFDYSNRAHINLL----- 881
            :..|.||..|.|:|.:...|..:|..:|||||:.|...:.|..              |.|
 Frog   369 DDEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQIKQMK--------------NALQQPEG 419

  Fly   882 ------CMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFMDPDKVSKPGS 940
                  ..:|:..||||:.|:..|:...|...||:|||.|...|...|||.:|..|.:......|
 Frog   420 IDKPKALSLLLHTADISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQS 484

  Fly   941 QVRFIGLVLLPLFEALGELVPELTELIIIPV-----RIALEYYRRLNDAQTKTRKSVADSNTSAT 1000
            |:.||..::.|.|..|.:::    |.|::|:     |..|..:||            :..|:..|
 Frog   485 QIGFIDFIVEPTFTVLTDMI----EKIVVPLIEEASRSGLTGFRR------------SSLNSITT 533

  Fly  1001 SDSNSGTIDSNAAMVSTPGGASDKLSLDKGQGNSQGSGGGGGGGGGGGAGGGTGSGCGSNAAGSV 1065
            ||....::.|.                                    |:.|.....|........
 Frog   534 SDVKRSSVKST------------------------------------GSEGSASLNCSILTVDFK 562

  Fly  1066 SPQMPRSGSGISVKSRRSIPSQ------KSASRTSVDEPGGMASELHDLPEGSESGDSETATEVD 1124
            |  ...:...:.:::|....:|      :.|.|.:.::......|.|     .|..|.:|....|
 Frog   563 S--FKCTWYDVVLQNREKWKTQAVKDADEKAKREAEEKDKRDPDENH-----QEKEDKKTDENED 620

  Fly  1125 VAEK--TSKFKVDTEGSSNRSKSSHSTSRKSSREKRPSMIGELCSSG 1169
            ..:|  .:|.:.:.|..|..||.:.|:....:..:.|:...:.||||
 Frog   621 KNDKPLLNKHEPNKEHHSGDSKLTESSQGNINGTRLPNAKNQECSSG 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	76/239 (32%)
pde1c	XP_031759760.1	PDEase_I_N	140..200	CDD:462497	15/65 (23%)
		PDEase_I	285..507	CDD:459723	76/239 (32%)