DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde9 and pde10a

DIOPT Version :9

Sequence 1:	NP_727644.3	Gene:	Pde9 / 32233	FlyBaseID:	FBgn0259171	Length:	1623	Species:	Drosophila melanogaster
Sequence 2:	XP_031757888.1	Gene:	pde10a / 100485841	XenbaseID:	XB-GENE-1013417	Length:	799	Species:	Xenopus tropicalis

Alignment Length:	297	Identity:	89/297 - (29%)
Similarity:	142/297 - (47%)	Gaps:	15/297 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   720 VDTLREWLYEVYKHYNEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDH 784
            ::.|..:...|.|:|..||:||::|...|:..||.|.:  |......|||...|||:|:||||||
Frog   510 LEKLCRFTMSVKKNYRRVPYHNWKHAVTVSHCMYVILQ--NNQEIFTDLERKGLLVACLCHDLDH 572

  Fly   785 PGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCIL 849
            .||.|.|.......||..|: .|.:|.||.|....:|:....|||.|.|.:.:..:.|.|.:.|:
Frog   573 RGYTNSYLQKFDHPLAALYS-TSTMEQHHFSQTVSILQLEGHNIFSNLSSNEYEQVLEIIRKAII 636

  Fly   850 ATDMA------RHNEILTQFMEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRL 908
            |||:|      :|.|.|.|...:    :.:|:||.:.|..:::...|:.:..:...|.....|.:
Frog   637 ATDLALYFGNRKHLEDLHQMGAL----NLNNQAHRDRLIGLMMTACDLCSVTKLWPVTRLIADDI 697

  Fly   909 LQEFFAQSAAEKSEGLPVTPFMDPDKVSK-PGSQVRFIGLVLLPLFEALGELVPELTELIIIPVR 972
            ..||:.:....|..|:...|.||.||..: |..|:.|...|.:|.:..|.|:.|. |..::...:
Frog   698 YAEFWTEGDEMKRLGISPIPMMDRDKQDEIPQGQMGFYNAVAVPCYTTLSEIFPS-TRPLLQACK 761

  Fly   973 IALEYYRRLNDAQTKTRKSVADSNTSATSDSNSGTID 1009
            ..|..:.:::..:..|....:.|..:.:|||....||
Frog   762 ENLSQWEKVSRGEDTTVWIPSQSLPTESSDSLPVKID 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:278654	75/234 (32%)
pde10a	XP_031757888.1	GAF	110..223	CDD:396252
		GAF	282..437	CDD:214500
		PDEase_I	529..761	CDD:395177	75/239 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010