Protein Alignment Pde9 and pde4c

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_004911040.1
• Gene: pde4c / 100380081
• XenbaseID: XB-GENE-1002336
• Length: 801
• Species: Xenopus tropicalis
• Alignment Length: 673
• Identity: 150/673 - (22%)
• Similarity: 279/673 - (41%)
• Gaps: 179/673 - (26%)

  Fly   562 SIKMRASATDIETN----ALNGARDAIVASNNGNNGNNGNNGNNEYSILQLNNTIIQCHFNDDDF 622
            :::.|.|.:::.:|    .||  |:....|....:||.    .:||    :::|.:......:..
 Frog   226 TLQTRHSVSEMASNKFKRMLN--RELTHLSETSRSGNQ----VSEY----ISSTFLDKQHEVEIP 280

  Fly   623 RALVKDLKRKVEYTERMNWLCLSKRPLGP-------PHRKS----SLPK-----HQEVKRRFLEI 671
            ..:.|:..:|             |||:..       .|..|    |:|:     .|||
 Frog   281 TPVSKEKDKK-------------KRPMSQISGVKKLTHSSSFSNCSIPRFGVKTEQEV------- 325

  Fly   672 CDTTFSEEVRAALR--LPAFDSYEWS-DADVIHLMQTMFVELGFIEKFSIPVDTLREWLYEVYKH 733
               ..::||....:  |..|...|:| :..:..:|.::|.|...::.|.|||||...::..:..|
 Frog   326 ---PLAKEVENINKWGLDIFKVAEYSGNRPLTVIMYSIFQERDLLKTFHIPVDTFITYMMTLEDH 387

  Fly   734 Y-NEVPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINART 797
            | ::|.:||..|...|||..:.:.....|.:...|||.:..:.:...||:||||.:|.:.||..:
 Frog   388 YHSDVAYHNNIHAADVAQSTHVLLSTPALEAVFTDLEIMAAIFASAIHDVDHPGVSNQFLINTNS 452

  Fly   798 ELALRYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARHNEILTQ 862
            ||||.|||.|.|||||.::.|:||:...|:||:|.::.....:|:.:|..:|||||::|..:|..
 Frog   453 ELALMYNDASVLENHHLAVGFKLLQEENCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMNLLAD 517

  Fly   863 F-----------MEITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQS 916
            .           :.:..:.:||:|..:   ...::..||:||..:|:::...|.||::.|||.|.
 Frog   518 LKTMVETKKVTSLGVLLLDNYSDRIQV---LQNMVHCADLSNPTKPLEIYRQWTDRIIVEFFHQG 579

  Fly   917 AAEKSEGLPVTPFMDPDKVSKPGSQVRFIGLVLLPLFEALGELV-PELTELIIIPVRIALEYYRR 980
            ..|:.:|:.::|..|....|...|||.||..::.||:|...:|| |:..|::
 Frog   580 DREREKGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQEIL------------- 631

  Fly   981 LNDAQTKTRKSVADSNTSATSDSNSGTIDSN-----AAMVSTPGGASDKLSLDKGQGNSQGSGGG 1040
                                     .|::.|     :.:..:|....::...|:|
 Frog   632 -------------------------DTLEDNREWYQSMIPQSPSPPPEEQDPDRG---------- 661

  Fly  1041 GGGGGGGGAGGGTGSGCGSNAAGSVSPQMPRSGSGISVKSRRSIPSQKSASRTSVDEPGGMASEL 1105
                               ||||.      :....::::......:::..:.:.:||... .|::
 Frog   662 -------------------NAAGD------KFQFELTLEEEGESDTEQEDTESPIDEENS-DSKI 700

  Fly  1106 HDLPEGSESGD-SETATEVD----VAEKTSKFKVDTEGSSNRSK--------------------- 1144
            |...:.:::.| :|.::.||    |:.|....::..:.:..:.|
 Frog   701 HATDDSAQASDEAEQSSPVDLCMTVSSKLDHLEIPPKSTLTKQKKILNFDNLKLAGERTIQQKEV 765

  Fly  1145 -SSHSTSRKSSREKRPSMIGELC 1166
             |||:|...|:|::.... .|:|
 Frog   766 SSSHATPANSARQEGTGQ-AEIC 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	80/239 (33%)
pde4c	XP_004911040.1	PDE4_UCR	156..272	CDD:465648	12/55 (22%)
		PDEase_I	394..634	CDD:459723	80/280 (29%)