Protein Alignment Pde9 and pde1b

DIOPT Version :10

• Sequence 1: NP_727644.3
• Gene: Pde9 / 32233
• FlyBaseID: FBgn0259171
• Length: 1623
• Species: Drosophila melanogaster
• Sequence 2: XP_017946519.1
• Gene: pde1b / 100036722
• XenbaseID: XB-GENE-987197
• Length: 554
• Species: Xenopus tropicalis
• Alignment Length: 482
• Identity: 123/482 - (25%)
• Similarity: 200/482 - (41%)
• Gaps: 101/482 - (20%)

  Fly   602 EYSILQLNNTIIQCHFNDDDFRALVKDLKRKVEYTERM---NWLCLSKRPLG-----PPHRKSSL 658
            :|.:.||.|..:.           :.:||:.:|||..:   .::..:::.|.     |..|..|:
 Frog    58 KYMVKQLENGEVN-----------IVELKKNLEYTASLLEAVYIDETRQILDTDDELPEMRSDSV 111

  Fly   659 P-------------------KHQEVKRRFLEICD----------------TTFSEEVRAA----- 683
            |                   :..|.|.||..|..                |.......||
 Frog   112 PSEVRDWLASTFTQQTRSTGRRSEEKPRFRSIVHAVQAGIFVERMFRRSYTAVGPNYSAAVVNSL 176

  Fly   684 --LRLPAFDSYEWSDADVIHLMQTMFVEL----GFIEKFSIPVDTLREWL------YEVYKHYNE 736
              |.|..||.:..:.....|.::|:..||    ....:|.|||..|..:|      |..||:
 Frog   177 KHLDLWDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMSFLDSLESGYGKYKN--- 238

  Fly   737 VPFHNFRHCFCVAQMMYAITRQANLLSRLGDLECLILLVSCICHDLDHPGYNNIYQINARTELAL 801
             |:||..|...|.|.::....:..::..|.::|.|.::.:...||.:|.|..|.:.|..:::.|:
 Frog   239 -PYHNQIHAADVTQTVHCFLLRTGMVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSDCAI 302

  Fly   802 RYNDISPLENHHCSIAFRLLEHPECNIFKNFSRDTFNNIREGIIRCILATDMARH-NEILTQFME 865
            .|||.|.|||||.|..:|:::..|.|||.|.::|.|..:|..:|..:|||||:.| .::.|....
 Frog   303 LYNDRSVLENHHVSAVYRIMQDDEMNIFVNLTKDEFTELRSLVIEMVLATDMSCHFQQVKTMKTS 367

  Fly   866 ITPIFDYSNRAHINLLCMILIKVADISNEARPMDVAEPWLDRLLQEFFAQSAAEKSEGLPVTPFM 930
            :..:........::|    |:..||||:..:...|...|...|::|||.|...|...|||.:|..
 Frog   368 LQQLETIDKSKALSL----LLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGLPFSPLC 428

  Fly   931 DPDKVSKPGSQVRFIGLVLLPLFEALGELVPELTELIIIPVRIALEYYRRLNDAQTKTRKSVADS 995
            |........||:.||..::.|.|..|    .::.|..::|          |.:.::|: ||.|..
 Frog   429 DRKSTLVAQSQIGFIEFIVDPTFSVL----TDVAEKTVLP----------LVEERSKS-KSTASV 478

  Fly   996 NTSATS------DSNSGTIDSNAAMVS 1016
            |.|::.      |.:|...|.||.:.|
 Frog   479 NQSSSQWRQPSIDDHSEMGDINADIKS 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde9	NP_727644.3	PDEase_I	739..967	CDD:459723	69/228 (30%)
pde1b	XP_017946519.1	PDEase_I_N	95..155	CDD:462497	10/59 (17%)
		PDEase_I	240..467	CDD:459723	71/244 (29%)