DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf128a and RNF128

DIOPT Version :9

Sequence 1:	NP_997780.1	Gene:	rnf128a / 322325	ZFINID:	ZDB-GENE-030131-1044	Length:	389	Species:	Danio rerio
Sequence 2:	NP_919445.1	Gene:	RNF128 / 79589	HGNCID:	21153	Length:	428	Species:	Homo sapiens

Alignment Length:	404	Identity:	212/404 - (52%)
Similarity:	265/404 - (65%)	Gaps:	41/404 - (10%)

- Green bases have known domain annotations that are detailed below.

Zfish     9 VFSW-LLLASVLQVSSVRLAEASYLCTAYLNISYTNPEN--NRSTWFQEEMGLYGQDSPKAYVKG 70
            :.:| .|||...|....|.|||.:  |||||:|:..|..  ||:.|...|.|:||||||...|.|
Human    20 LLAWCFLLALSPQAPGSRGAEAVW--TAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAG 82

Zfish    71 NVYLASP-----TYGCDDDTFYGRPN--GSK---GWIALIQRGNGCTFTEKINIAAMNGAAAAII 125
              .|..|     ...|:..|.:..|.  ||.   .|:||||||.||||.:||::|...||:.|:|
Human    83 --VLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVI 145

Zfish   126 FNDFGSENRVIQMSHPGTT-IVAIMIGNYRGMELVQLLDQGVPVAIAIEVGKQHGPWMSHYSVFF 189
            ||..|:.|.||.|||||.. ||||||||.:|.:::|.:.:|:.|.:.|||||:||||::|||:||
Human   146 FNFPGTRNEVIPMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFF 210

Zfish   190 VSISFFIVTAATVGYFIFYSARRLNSLRQQNRSQKKLKAEAKKAIGQLQVRTLRQGDQEIGPDAD 254
            ||:||||:||||||||||||||||.:.|.|:|.|::|||:||||||:||:|||:|||:|||||.|
Human   211 VSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGD 275

Zfish   255 ACAVCIDSYKAGDVLSILTCNHFFHKSCIEPWLLEHRTCPMCKCDILKALGVELDVEE-QPQISV 318
            :|||||:.||..|::.||||||.|||:|::|||||||||||||||||||||:|:|||: ...:.|
Human   276 SCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQV 340

Zfish   319 PDFRPFSTSEDLHSETASHTHSETASSGYASMHGNEHLAPPEGTH---------------NGVQE 368
            |.....|.|...|.|   ...||||||||||:.|.:.  ||...|               |.|..
Human   341 PVSNEISNSASSHEE---DNRSETASSGYASVQGTDE--PPLEEHVQSTNESLQLVNHEANSVAV 400

Zfish   369 E--PHYDNLAFESD 380
            :  ||.||..||.|
Human   401 DVIPHVDNPTFEED 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf128a	NP_997780.1	PA_GRAIL_like	38..172	CDD:239037	64/146 (44%)
rnf128a	NP_997780.1	zf-RING_2	256..297	CDD:290367	29/40 (73%)
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037	64/146 (44%)
		RING-H2_RNF128_like	275..323	CDD:319716	35/47 (74%)
		RING-H2 finger (C3H2C3-type)	277..317	CDD:319716	28/39 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..428		27/74 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324499
Domainoid	1	1.000	146	1.000	Domainoid score	I18421
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11337
Inparanoid	1	1.050	379	1.000	Inparanoid score	I8223
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39235
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0011956
OrthoInspector	1	1.000	-	-		oto43721
orthoMCL	1	0.900	-	-		OOG6_115655
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10675
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300