DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf128a and Rnf128

DIOPT Version :9

Sequence 1:	NP_997780.1	Gene:	rnf128a / 322325	ZFINID:	ZDB-GENE-030131-1044	Length:	389	Species:	Danio rerio
Sequence 2:	NP_075759.3	Gene:	Rnf128 / 66889	MGIID:	1914139	Length:	428	Species:	Mus musculus

Alignment Length:	409	Identity:	211/409 - (51%)
Similarity:	266/409 - (65%)	Gaps:	37/409 - (9%)

- Green bases have known domain annotations that are detailed below.

Zfish     2 GPLASRDVFSW-LLLASVLQVSSVRLAEASYLCTAYLNISYTNPEN--NRSTWFQEEMGLYGQDS 63
            |...:..:.:| .|||........|.|||.:  |||||:|:..|..  ||:.|...|.|:|||||
Mouse    13 GGCGAARLLAWCFLLALSPHAPGSRGAEAVW--TAYLNVSWRVPHTGVNRTVWELSEEGVYGQDS 75

Zfish    64 PKAYVKGNVYLASP-----TYGCDDDTFYGRPN--GSK---GWIALIQRGNGCTFTEKINIAAMN 118
            |...|.|  .|..|     ...|:..|.:..|.  ||.   .|:||||||.||||.:||::|:..
Mouse    76 PLEPVSG--VLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLASER 138

Zfish   119 GAAAAIIFNDFGSENRVIQMSHPGT-TIVAIMIGNYRGMELVQLLDQGVPVAIAIEVGKQHGPWM 182
            ||:.|:|||..|:.|.||.|||||. .||||||||.:|.:::|.:.:|:.|.:.|||||:||||:
Mouse   139 GASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWV 203

Zfish   183 SHYSVFFVSISFFIVTAATVGYFIFYSARRLNSLRQQNRSQKKLKAEAKKAIGQLQVRTLRQGDQ 247
            :|||:||||:||||:||||||||||||||||.:.|.|:|.|::|||:||||||:||:|||:|||:
Mouse   204 NHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGKLQLRTLKQGDK 268

Zfish   248 EIGPDADACAVCIDSYKAGDVLSILTCNHFFHKSCIEPWLLEHRTCPMCKCDILKALGVELDVEE 312
            |||||.|:|||||:.||..|::.||||||.|||:|::|||||||||||||||||||||:|:|||:
Mouse   269 EIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVED 333

Zfish   313 -QPQISVPDFRPFSTSEDLHSETASHTHSETASSGYASMHG------NEH---------LAPPEG 361
             ...:.||.....|.:...|.|   .:.||||||||||:.|      .||         |...|.
Mouse   334 GSVSLQVPVSNEASNTASPHEE---DSRSETASSGYASVQGADEPPLEEHAQSANENLQLVNHEA 395

Zfish   362 THNGVQEEPHYDNLAFESD 380
            ....|...||.||..||.|
Mouse   396 NSVAVDVVPHVDNPTFEED 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf128a	NP_997780.1	PA_GRAIL_like	38..172	CDD:239037	64/146 (44%)
rnf128a	NP_997780.1	zf-RING_2	256..297	CDD:290367	29/40 (73%)
Rnf128	NP_075759.3	PA_GRAIL_like	48..193	CDD:239037	64/146 (44%)
		zf-RING_2	275..318	CDD:290367	30/42 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..428		26/76 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C193126092
Domainoid	1	1.000	146	1.000	Domainoid score	I18281
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11337
Inparanoid	1	1.050	379	1.000	Inparanoid score	I8165
OMA	1	1.010	-	-		QHG39235
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0011956
OrthoInspector	1	1.000	-	-		otm29569
orthoMCL	1	0.900	-	-		OOG6_115655
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10675
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800