DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Agpat1 and lpcat2

DIOPT Version :9

Sequence 1:	NP_001259494.1	Gene:	Agpat1 / 32230	FlyBaseID:	FBgn0030421	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001018492.1	Gene:	lpcat2 / 553683	ZFINID:	ZDB-GENE-050522-229	Length:	529	Species:	Danio rerio

Alignment Length:	303	Identity:	67/303 - (22%)
Similarity:	112/303 - (36%)	Gaps:	80/303 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IELLGLFLLLMLPFLYETNHI--FRYYFKFLMYYGIVSFNSIILIPAFLTRPCDVRNLLWASTWC 70
            :.|..:||||:|..::..:.|  |....|     |:|.       |  :|.        |.....
Zfish    47 VPLRAIFLLLVLLVMWPVSVIITFGQSLK-----GVVE-------P--MTG--------WRRFLH 89

  Fly    71 HRVSTLI--------GLRWELRGKEHLAKDQACIIVANHQSSLDVLGMFNIWHVMNKC------T 121
            .||.|.:        |.:..::||:....:...:.||.|.|..|.:.          |      :
Zfish    90 RRVMTFLGRMYFFGMGFKVVVKGKKASTLEAPILAVAPHSSFFDAIA----------CIESGLPS 144

  Fly   122 VVAKRELFYAWPFGLAAWLAGLIFIDRVRGEKARETLNDVNRRIKK--QRIKLWVFPEGTRRNTG 184
            .|::.|...|..||........:.:.|...:..|.|:.::.||.|.  ...::.:|||||..|..
Zfish   145 TVSRIESLEAPIFGRFLRCVQPVLVSRTDPDSRRNTIIEIERRAKSGGHWPQVLIFPEGTCTNRS 209

  Fly   185 ALHPFKKGAFHMAIDQQIPILPVVFSSYCTFLNDKKKIL------NSGRIVITTL---------- 233
            .|..||:|.|...    :|:.||:.    .:.|....:.      .|.|:::.||
Zfish   210 CLITFKQGGFVPG----VPVQPVLI----RYPNKLDTVTWTWQGPKSARLLLLTLCQLCTTVEVE 266

  Fly   234 ---PPVSTEGLTKDDIDVLMERVRSQMIETFKVTSAEALHRYK 273
               |.|.||...|..:. ..:.||:.|.::.|:...:  |.|:
Zfish   267 FLPPQVPTEMEKKCPLK-FAQSVRAVMAKSLKLPVTD--HTYE 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Agpat1	NP_001259494.1	LPLAT_AGPAT-like	70..254	CDD:153251	47/218 (22%)
lpcat2	NP_001018492.1	PlsC	49..297	CDD:223282	64/288 (22%)
		LPLAT_LPCAT1-like	98..309	CDD:153253	50/230 (22%)
		HXXXXD motif. /evidence=ECO:0000250\|UniProtKB:Q3TFD2	128..133		2/4 (50%)
		EGTC motif	202..205		2/2 (100%)
		EFh	316..406	CDD:298682
		EFh	378..440	CDD:238008
		EF-hand_7	378..435	CDD:290234
		EF-hand_7	415..473	CDD:290234
		EFh	418..473	CDD:238008
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810