Protein Alignment Agpat1 and AGPAT5

DIOPT Version :10

• Sequence 1: NP_572828.1
• Gene: Agpat1 / 32230
• FlyBaseID: FBgn0030421
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: NP_060831.2
• Gene: AGPAT5 / 55326
• HGNCID: 20886
• Length: 364
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 77/343 - (22%)
• Similarity: 126/343 - (36%)
• Gaps: 88/343 - (25%)

  Fly    18 MLPFLYETNHIFRYYFKFLMYYG-----IVSFNSIILIPAFLTRPCDVRNLLWASTWCHRVSTLI 77
            ||..|....:..||....::..|     ::::....|:.|||  |......|....:|...|.::
Human     1 MLLSLVLHTYSMRYLLPSVVLLGTAPTYVLAWGVWRLLSAFL--PARFYQALDDRLYCVYQSMVL 63

  Fly    78 -------GLRWELRGKEHLAKDQACII-VANHQSSLDVLGMFNIWHVMNKCTVVAKRE-----LF 129
                   |::..|.|  .|.|::..|| :|||||::|       |.|.:   ::|.|:     :.
Human    64 FFFENYTGVQILLYG--DLPKNKENIIYLANHQSTVD-------WIVAD---ILAIRQNALGHVR 116

  Fly   130 YAWPFGLAAWLA---------GLIFIDRVRGEKARETLNDVNRRIKK-QRIKLWVFPEGTRRN-- 182
            |....|| .||.         |.|::.|......:|..|.:...:.. ..:.|.:||||||.|
Human   117 YVLKEGL-KWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPE 180

  Fly   183 ----TGALHPF--KKG-------------AFHMAIDQQIPILPVVFSSYCTFLNDKKKILNSGRI 228
                ..|...|  ::|             |.|:|.|.....|..::.  .|.:.:.|.  :.|:
Human   181 QTKVLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYD--VTVVYEGKD--DGGQ- 240

  Fly   229 VITTLPPVSTEGLTKD--------------DIDVLMERVRSQMIETFKVTSAEALHRYK---PIK 276
              ....|..||.|.|:              |:....|.:|..:.|.|::.....:..|:   |.:
Human   241 --RRESPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYESPDPER 303

  Fly   277 KVGIPAASSASTSSTTTT 294
            :...|..|..|..|...|
Human   304 RKRFPGKSVNSKLSIKKT 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Agpat1	NP_572828.1	PlsC	65..259	CDD:439974	56/251 (22%)
AGPAT5	NP_060831.2	LPLAT_LCLAT1-like	63..263	CDD:153252	51/219 (23%)
		HXXXXD motif. /evidence=ECO:0000250|UniProtKB:Q9D517	93..98		3/4 (75%)
		Acyltransf_C	258..312	CDD:465006	8/53 (15%)