DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Agpat1 and Lpcat2

DIOPT Version :9

Sequence 1:	NP_001259494.1	Gene:	Agpat1 / 32230	FlyBaseID:	FBgn0030421	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001258273.1	Gene:	Lpcat2 / 100359680	RGDID:	2325051	Length:	544	Species:	Rattus norvegicus

Alignment Length:	325	Identity:	59/325 - (18%)
Similarity:	102/325 - (31%)	Gaps:	133/325 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLGLFLLLMLPFLYETNHIFRYYFKFLMYYGIVSFNSIILIPAFLTRPCDVRNLLWASTWCHRVS 74
            |:||.|||..||                     :..|.:..|..||.|        .|.|..:::
  Rat    72 LVGLVLLLAWPF---------------------AVISTVCCPKKLTHP--------ISDWRRKIT 107

  Fly    75 T------------LIGLRWELRGKEHLAKDQACIIVANHQSSLDVLGMFNIWHVMNKCTVVAKRE 127
            .            .:|.|..::||.....:....:||.|.:..|
  Rat   108 QPALKFLGRAMFFSMGFRVTVKGKVASPLEAPIFVVAPHSTFFD--------------------- 151

  Fly   128 LFYAWPFGLAAWLAGL------------------------IFIDRVRGEKARETLNDVNRRIKK- 167
                   |:|..:|||                        :.:.||..:..:.|:|::.:|...
  Rat   152 -------GIACVVAGLPSLVSRNENAQTPLVGRLLRALQPVLVSRVDPDSRKNTINEIKKRAMSG 209

  Fly   168 -QRIKLWVFPEGTRRNTGALHPFKKGAFHMAIDQQIPILPVVFS--------------------- 210
             :..::.||||||..|...|..||.|||...    :|:.||:..
  Rat   210 GEWPQILVFPEGTCTNRSCLITFKPGAFIPG----VPVQPVLLRYPNKLDTVTWTWQGYTFIQLC 270

  Fly   211 --SYCTFLNDKKKILNSGRIVITTLPPVSTEGLTKDDIDVLMERVRSQMIETFKVTSAEALHRYK 273
              ::|....         ::.:..:|..:.....::|..:...|||:.|.|..::...:  |.|:
  Rat   271 VLTFCQLFT---------KVEVEFMPVQAPSEEERNDPVLFASRVRNLMAEALEIPVTD--HTYE 324

Fly 274 273
Rat 325 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Agpat1	NP_001259494.1	LPLAT_AGPAT-like	70..254	CDD:153251	38/244 (16%)
Lpcat2	NP_001258273.1	PlsC	103..>254	CDD:223282	34/182 (19%)
		LPLAT_LPCAT1-like	116..327	CDD:153253	44/252 (17%)
		HXXXXD motif. /evidence=ECO:0000250\|UniProtKB:Q3TFD2	146..151		1/4 (25%)
		EGTC motif	220..223		2/2 (100%)
		EFh	396..458	CDD:238008
		EF-hand_7	396..457	CDD:290234
		EF-hand_7	433..489	CDD:290234
		EFh	433..486	CDD:238008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..544
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810