DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12717 and ULP2

DIOPT Version :9

Sequence 1:	NP_001285167.1	Gene:	CG12717 / 32229	FlyBaseID:	FBgn0030420	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_012233.1	Gene:	ULP2 / 854780	SGDID:	S000001293	Length:	1034	Species:	Saccharomyces cerevisiae

Alignment Length:	571	Identity:	121/571 - (21%)
Similarity:	236/571 - (41%)	Gaps:	151/571 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 KHKKSPCGSPGENNDGQVILSADQDANTNTKAKKQK---------KCH---IAKDNNGIQAASSH 223
            ||...|..|...:.:.:..:::.::|..:.:.||.|         :.|   ::...:|:|:.:..
Yeast   288 KHLIHPISSSSPSLNMERAINSTKNAFDSLRLKKTKLSTNDDESPQIHTHFLSNKPHGLQSLTKR 352

  Fly   224 DNPSSSGNKQGSHNSTAITSNSTMTSNGLRGVQPAEDAPAISQWIQSRNNAAVSKKSEETAGGSQ 288
            ...:|.|.|:  |:.:...||                               :|........|::
Yeast   353 TRIASLGKKE--HSISVPKSN-------------------------------ISPSDFYNTNGTE 384

  Fly   289 SRVQSNVASISSPAVKATSDAAIPTPAERAERSRLRRNRNWILSRDVDEDAVVLVSSGDEETTAA 353
                    ::.|.||                 |:|||:..:   :||.:.|      .....:..
Yeast   385 --------TLQSHAV-----------------SQLRRSNRF---KDVSDPA------NSNSNSEF 415

  Fly   354 DDGQTERRLSPDENQTLFTYPPTGTGGLSITIKDFMCLSKGSYLNDIIIDFYLRW-----LKNNI 413
            ||..||.. :|:..:....|........:||.:||.||....::||.|:||:.::     ::.:|
Yeast   416 DDATTEFE-TPELFKPSLCYKFNDGSSYTITNQDFKCLFNKDWVNDSILDFFTKFYIESSIEKSI 479

  Fly   414 IPEEQRDRTHIFSTFFHKRLTTRTNPRNTKQTAAQKRHERVEKWTRNVNIFDKDFIIIPFNEQSH 478
            |   :|::.|:.|:||:.:|.  :||.:        .:..|:||..|.::|.|.:::||.|...|
Yeast   480 I---KREQVHLMSSFFYTKLI--SNPAD--------YYSNVKKWVNNTDLFSKKYVVIPINISYH 531

  Fly   479 WILAIICYPNLRSPV---VNNNNVQTTLSDDIPIKQPL--ILIFDSLAVTSRHRAIAILRDYLTC 538
            |...||  .||.:.:   .|.:......||:|.|..||  ||.||||..| ..|.|..::::|..
Yeast   532 WFSCII--TNLDAILDFHQNKDKNDAINSDEISINNPLVNILTFDSLRQT-HSREIDPIKEFLIS 593

  Fly   539 EHKAKYPNALAHVFNKDNMPGHSVEVPQQQNLTDCGLYLLQYVEQFFTKPINDYTLPI------- 596
            ....||...|    :|..:...:..||||.|::|||::::..:.:||..|:.  |:.:
Yeast   594 YALDKYSIQL----DKTQIKMKTCPVPQQPNMSDCGVHVILNIRKFFENPVE--TIDVWKNSKIK 652

  Fly   597 ------KELSNWFDLLTVTKKREDIANLIKKL-------MNESNQQRKILPV--IKFPTLNGQLV 646
                  |.::.:||.......|:::.:.:|.|       :.:.|...:::.:  .|...:|....
Yeast   653 SKHFTAKMINKYFDKNERNSARKNLRHTLKLLQLNYISYLKKENLYEEVMQMEEKKSTNINNNEN 717

  Fly   647 MDEEDSE-------EENSKEEH----------KTTLVCSKDRKPPRRRNTL 680
            .|::|.|       :::||:.:          :::.:.:.:|:|....|::
Yeast   718 YDDDDEEIQIIENIDQSSKDNNAQLTSEPPCSRSSSISTTEREPTELHNSV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12717	NP_001285167.1	BASP1	122..319	CDD:283191	22/159 (14%)
CG12717	NP_001285167.1	Peptidase_C48	396..585	CDD:304959	59/198 (30%)
ULP2	NP_012233.1	ULP1	45..695	CDD:227489	110/496 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346103
Domainoid	1	1.000	106	1.000	Domainoid score	I1447
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6692
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000929
OrthoInspector	1	1.000	-	-		otm46731
orthoMCL	1	0.900	-	-		OOG6_102905
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1602
SonicParanoid	1	1.000	-	-		X756
TreeFam	0	0.000	Not matched by this tool.
	10	9.620