DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12717 and Senp7

DIOPT Version :9

Sequence 1:	NP_001285167.1	Gene:	CG12717 / 32229	FlyBaseID:	FBgn0030420	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_079759.2	Gene:	Senp7 / 66315	MGIID:	1913565	Length:	1037	Species:	Mus musculus

Alignment Length:	732	Identity:	196/732 - (26%)
Similarity:	290/732 - (39%)	Gaps:	248/732 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 RKVHQS-KASSADAAPPNAMAGEE-HSPAV--------VKPSETAVANNGCQPAAS--------- 165
            ||:.:| :.|..|.|||..:|.|. .|.|.        .:|..:|.:.....|..|
Mouse   330 RKLEESGEDSHQDPAPPEGLAPESLESEATNLRSFAAGQEPDASAASGRASSPNKSLESSASSEV 394

  Fly   166 ------ATKGK----KHKKSPCGSPGEN----NDGQVILSADQDANTNTK----AKKQKKCHIAK 212
                  |.||:    |....|.||..|:    :...:::|:|::.....|    .|.|....|..
Mouse   395 SENSSVAVKGEALTLKEASPPGGSSEESQLLISAEPIVVSSDEEGPVEHKNSVILKLQPPHEIMS 459

  Fly   213 DNNG----------------IQAASS--HDNP---------SSS-------------------GN 231
            :|.|                :|..|.  ..||         |:|                   |.
Mouse   460 ENQGTSDPQLSELTLGACESVQVTSELFPYNPDVENISCIKSNSEMDLKLDFIFTCVYIGKIKGT 524

  Fly   232 KQG---------------SHNSTAITSNST--------------------------MTSNGLRGV 255
            .:|               |.|..::|.::.                          ::|:.|:.:
Mouse   525 PKGCVTFTKKYIKIPFQVSTNEISLTVDTARLKRFGLWESKDEDHSKRSHAILFLWLSSDYLQDI 589

  Fly   256 QPAEDAPAISQWIQSRN------NAAVSKKSE----------ETAGGSQSRVQSNVASISSPAVK 304
            |...:.|.:||..::..      |:::|::.|          .|..|:..      .|...|.|:
Mouse   590 QTQLENPMLSQQSKANEFIFLELNSSISQREELKLKDIMMEISTKNGNLH------LSCPLPWVQ 648

  Fly   305 A-------------------TSDAAIPTP--AERAERSRLRRNRNWILSRDVDEDAV-------- 340
            |                   .|.:|:||.  |:..::|         :|:..:.|.:
Mouse   649 ALPLFQDLSPQEISFLHYYYASASALPTAAGADMKKKS---------VSQPSNSDTIKPTYTFLH 704

  Fly   341 --------VLVSSGDEETTAADDGQTERRLSPDENQTLFTYPPTGT-GGLSITIKDFMCLSKGSY 396
                    :.::|..||     :.|..|...|  .|.|..|||..| |||.:|.:|..||.:|.:
Mouse   705 KQSSGCYSLSITSSPEE-----EWQEVRNTGP--VQKLIVYPPPPTKGGLGVTNEDLECLEEGEF 762

  Fly   397 LNDIIIDFYLRWLKNNIIPEEQRDRTHIFSTFFHKRLTTRTN---PRNTKQTAAQKRHERVEKWT 458
            |||:||||||::|......:|..:|:||||:||:|.||.:.|   ..|...:.||:||.||..||
Mouse   763 LNDVIIDFYLKYLLLEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPDLSVAQRRHRRVRTWT 827

  Fly   459 RNVNIFDKDFIIIPFNEQSHWILAIICYPNLRSPV----------------------VNNNNVQT 501
            |::|||:||:|.:|.||.|||.||:||:|.|...|                      :.:|:..|
Mouse   828 RHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDCPQTVSQQFQGQQSQHDHKMTDNDPHT 892

  Fly   502 T--------------LSDDIP---IKQPLILIFDSLAVTSRHRAIAILRDYLTCEHKAKYPNALA 549
            |              ::..:|   .|:|.|||.|||...|....:..||:||..|.:.|  ....
Mouse   893 TSTVSTSAEDSQSTEVNMSVPKKMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVK--RKTH 955

  Fly   550 HVFNKDNMPGHSVEVPQQQNLTDCGLYLLQYVEQFFTKPINDYTLPIKELSNWFDLLTVTKKRED 614
            ..|:|.||.....:||:|.|.:|||:|||||||.||..||.::.||| .|..||....:..||||
Mouse   956 REFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFQDPIVNFELPI-HLEKWFPRHVIKTKRED 1019

  Fly   615 IANLIKKLMNESNQQRK 631
            |..||.||   ..||:|
Mouse  1020 IRELILKL---HLQQQK 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12717	NP_001285167.1	BASP1	122..319	CDD:283191	61/357 (17%)
CG12717	NP_001285167.1	Peptidase_C48	396..585	CDD:304959	88/230 (38%)
Senp7	NP_079759.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..399		16/68 (24%)
		ULP1	<743..1033	CDD:227489	118/295 (40%)
		Protease. /evidence=ECO:0000250	747..1037		116/293 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..909		3/35 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842149
Domainoid	1	1.000	161	1.000	Domainoid score	I3997
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6692
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000929
OrthoInspector	1	1.000	-	-		otm57819
orthoMCL	1	0.900	-	-		OOG6_102905
Panther	1	1.100	-	-	O	PTHR46896
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1602
SonicParanoid	1	1.000	-	-		X756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.680