DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12717 and Senp6

DIOPT Version :9

Sequence 1:	NP_001285167.1	Gene:	CG12717 / 32229	FlyBaseID:	FBgn0030420	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001100312.2	Gene:	Senp6 / 300860	RGDID:	1304565	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1009	Identity:	212/1009 - (21%)
Similarity:	334/1009 - (33%)	Gaps:	427/1009 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DRKETVSKDQAVRRIAHNDFIL--------VSRQLLINRADTDPD-KGSARMLIIYSSGKQHIVT 57
            ||||.......|.:..:|..:|        |.::...:.:..:|: |...:.       |:|..|
  Rat   154 DRKERKEYPPHVHKAENNPVMLSHGQGGDHVMKKTEDSESYVEPEVKRKVQQ-------KRHCST 211

  Fly    58 FKLPNLA-------------------------------CRVQDLFFQMDLQIDESTTIDCIENAG 91
            ::|..|:                               |:...:.|..|||.:....:...|:.|
  Rat   212 YQLSPLSPASKKCLTHFEVSEQRECCPKCGKEKENQTRCQSCGIVFHNDLQRNCRQAVTLNESTG 276

  Fly    92 GIIHLVV--SVGFPISDNIAETVAHAEEFYRKVHQSKASSADAAPPNAMA---GEEHSPAVVKPS 151
            .::...:  :.|...|.|...|   |::||       .:|.|..|.:.:.   |..|:  .::.:
  Rat   277 PLLRTSIHQNSGGQKSQNTGLT---AKKFY-------GNSVDKIPIDILLTCDGSRHN--YIQTN 329

  Fly   152 ETAVANNGCQPAASATKGKKHKKSPCGSPGENNDGQVILSADQDANTNTKAKKQKKCHIAKDNNG 216
            ...:...|..|..:..|.:|...|....|       :|||:|.|.:.:...:::.......|:
  Rat   330 GKVILPGGKIPKITNPKERKTSVSDLNDP-------IILSSDDDDDDDRTKRRESTSPQPADS-- 385

  Fly   217 IQAASSHDNPSSSGNKQGSHNSTAITSNSTMTSNGLRGVQPAEDAPAISQWIQSRNNAAVSKKS- 280
              |.||   |:.|..|          ..:.:.:|..|..|....:||.|:    .|...:.:|:
  Rat   386 --ACSS---PAPSTGK----------VEAALNANTCRAEQEPRSSPAESE----LNTVVIPRKAR 431

  Fly   281 -EETAGGSQS------RVQSN-----VASIS------------------------SPAVKA---- 305
             ::..|.|.|      :|.::     |.|:|                        .|.:.:
  Rat   432 MKDQLGNSISTPLKRRKVNTHGALIPVTSLSCQDFGSVILNCRSIRVGTLFRLLVEPVIFSLELI 496

  Fly   306 ---------------TSD-----------------AAIPTPAER--AERSRLRRNRNW------- 329
                           |||                 .|||...::  .:....:.::.|
  Rat   497 KIRLDGPDSVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSLQLQMSKEDKVWNDCKGIN 561

  Fly   330 ------------ILSRDVDEDAVVLVSS--------------------------------GDEET 350
                        |....:|..|.|:..|                                ..||:
  Rat   562 RITSLEEQYIILIFQTGLDHQADVVFESIITDIGIRNNVCNFFAKIPFEEANSRLVACTRSYEES 626

  Fly   351 TAADDGQTERRL------------------------SPDENQTLF--------TY-PPTGTGGLS 382
            ...:..|.|.::                        ...|:.|:|        .| ||...||:|
  Rat   627 IKGNCVQKENKVKTVSFESKIQLRSKQELQFFDDEEEAGESHTIFIGPVEKLIVYPPPPAKGGIS 691

  Fly   383 ITIKDFMCLSKGSYLNDIIIDFYLRWLKNNIIPEEQRDRTHIFSTFFHKRLT--TRTNPRNTKQT 445
            :|.:|..|||:|.:|||:||||||::|....:.:|..||.||||:||:|||.  .|.|...|..:
  Rat   692 VTNEDLHCLSEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERRNSETTNLS 756

  Fly   446 AAQKRHERVEKWTRNVNIFDKDFIIIPFNEQSHWILAIICYPNLRSPVVNNN------------- 497
            ..||||.||:.|||:|:||:||||.:|.||.:||.||::|:|.|..|....|
  Rat   757 IQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPKYEPNPHYHENAVMQKPS 821

  Fly   498 ---------------------------------------------------------NVQTTL-- 503
                                                                     :|:.::
  Rat   822 RAEDSYVSSASEVDACSQNSAAKPVIKKMLHRKHCLAVTDSSAAQEDSEPCYRRNAYSVKCSMKK 886

  Fly   504 ----------------------------------------------------------------- 503

  Rat   887 KNHAVHENEEPSNGESACQEISDRTESEHGLQDECLNSAHHPDALSKIRLNYGDQSAEGGKLLED 951

  Fly   504 ---------------SDD-------------------IPIKQPLILIFDSLAVTSRHRAIAILRD 534
                           |||                   ...|||.||:.|||...||...:.|||:
  Rat   952 ELIDFSEDQDDPDDSSDDGLLADENYNSEIGQWHLKPTVCKQPCILLMDSLRGPSRSNVVKILRE 1016

  Fly   535 YLTCEHKAKYPNALAHVFNKDNMPGHSVEVPQQQNLTDCGLYLLQYVEQFFTKPINDYTLPIKEL 599
            ||..|.:.|  ......|:||.|.|.:.:||||.|.:|||:|:|||||.||..||.::.||: .|
  Rat  1017 YLEVEWEVK--KGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILNFELPM-NL 1078

  Fly   600 SNWFDLLTVTKKREDIANLIKKLMNESNQQRKIL 633
            .|||....:..|||:|.|:|.||..|.::::::|
  Rat  1079 VNWFPPPRMKTKREEIRNIILKLQEEQSKEKRLL 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12717	NP_001285167.1	BASP1	122..319	CDD:283191	45/274 (16%)
CG12717	NP_001285167.1	Peptidase_C48	396..585	CDD:304959	93/361 (26%)
Senp6	NP_001100312.2	Peptidase_C48	704..>816	CDD:304959	53/111 (48%)
Senp6	NP_001100312.2	Peptidase_C48	<996..1072	CDD:304959	37/77 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000929
OrthoInspector	1	1.000	-	-		otm45148
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46896
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890