DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12717 and Semp2l2b

DIOPT Version :9

Sequence 1:	NP_001285167.1	Gene:	CG12717 / 32229	FlyBaseID:	FBgn0030420	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_444494.1	Gene:	Semp2l2b / 114671	MGIID:	2149738	Length:	495	Species:	Mus musculus

Alignment Length:	513	Identity:	108/513 - (21%)
Similarity:	175/513 - (34%)	Gaps:	171/513 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 HQSKASSADAAPPNAMAGEEHSPAVVKPSETAVANNGCQPAASATKGKKHKKSPCG-------SP 180
            |.||   .....|.....::..|..:..........|.:||..   ||.||: |..       ||
Mouse    69 HPSK---GQVRKPQGKTPKQLEPLELTEGSPEQVVTGRKPADG---GKGHKR-PYSVMEENEQSP 126

  Fly   181 GENNDGQVI--LSADQDAN----------TNT-KAKKQKKCHIAKDNNGIQAASSHDNPSS---- 228
            .:...|:::  |..|||.:          ||| |.|..:    ::|:.|.:...|...||:
Mouse   127 QKEKYGRLLQHLQCDQDVSSDPHRPHPFLTNTWKIKGGE----SEDSRGSERTQSDREPSTVVAL 187

  Fly   229 -------SGNKQGSHNSTAITSNSTMTSNGLRGVQPAEDAPAISQWI---QSRNNA--------- 274
                   ...|..|...........:...|.||.....|.|.....|   ..:.|:
Mouse   188 KECLSPEEREKCCSEEKCVTEKKDCIKGEGRRGNSLEPDLPGTQAQIILDSGKGNSLFPNKVAVL 252

  Fly   275 AVSKKSEETAGGSQSRVQSNVASISSPAVKATSDAAIPTPAERAERSRLRRNRNWILSRDVDEDA 339
            |..||.....|  :.|....:..|:....|...:|..|.|.|....||.:
Mouse   253 AAEKKPITDRG--KGREMDQILDITEDMEKEIENALGPGPQEEILSSRFK--------------- 300

  Fly   340 VVLVSSGDEETTAADDGQTERRLSPDENQTLFTYPPTGTGGLSITIKDFMCLSKGSYLNDIIIDF 404
             :.:|.||.:|                                        |..|.:|||.:|:|
Mouse   301 -LQISRGDIQT----------------------------------------LENGQWLNDEVINF 324

  Fly   405 YLRWLKNNIIPEEQRDR----THIFSTFFHKRLTTRTNPRNTKQTAAQKRH---ERVEKWTRNVN 462
            |:     |::.|...::    .|:|||||:.:|                :|   ..|::|||.:|
Mouse   325 YM-----NLLVERNENQGYPALHVFSTFFYPKL----------------KHGGYSSVKRWTRGIN 368

  Fly   463 IFDKDFIIIPFNEQSHWILAIICYPNLRSPVVNNNNVQTTLSDDIPIKQPLILIFDSLAVTSRHR 527
            :|:|:.|::|.:::.||.|.:                       |.:::..|:..||:..|.:..
Mouse   369 LFEKELILVPIHQRVHWSLVV-----------------------IDLRKRSIVYLDSMGQTGKSI 410

  Fly   528 AIAILRDYLTCEHKAKYPNALAHVFNKDNMPGHSV---EVPQQQNLTDCGLYLLQYVE 582
            ...|.: ||..|.|.:....|..:..|.    :||   |:|.|.|.:|||::..:|.:
Mouse   411 CETIFQ-YLQNESKTRRNVELDPLEWKQ----YSVTSEEIPLQLNGSDCGMFTCKYAD 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12717	NP_001285167.1	BASP1	122..319	CDD:283191	50/238 (21%)
CG12717	NP_001285167.1	Peptidase_C48	396..585	CDD:304959	50/197 (25%)
Semp2l2b	NP_444494.1	Peptidase_C48	<272..490	CDD:304959	64/297 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810