DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Paics and paics

DIOPT Version :9

Sequence 1:	NP_572826.1	Gene:	Paics / 32228	FlyBaseID:	FBgn0020513	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_955831.1	Gene:	paics / 321193	ZFINID:	ZDB-GENE-030131-9762	Length:	425	Species:	Danio rerio

Alignment Length:	426	Identity:	246/426 - (57%)
Similarity:	321/426 - (75%)	Gaps:	7/426 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTTTTASIEGYKLGKVIIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTT 65
            |||.|.     .|||:.:.||||||::::.::||..|:.|||:||||:.|:...:.|||.|:|.|
Zfish     1 MSTATE-----LKLGQKLNEGKTKQIFEILDEPGHVLVQSKDQITAGNAVRKDQMEGKAAIANKT 60

  Fly    66 NGQVFRLLNEAGIRTAYVKQCGAKAFIARKCQMIPIEWVTRRLATGSFLKRNVGVPEGYRFSPPK 130
            ...||:||.:||::||:|:|....||:|.:|:|||||||.||:|||||||||.||.|||||:|.|
Zfish    61 TSCVFKLLQDAGLKTAFVRQHSDTAFVASRCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFTPLK 125

  Fly   131 QETFFKDDANHDPQWSEEQIVSAKFELNGLVIGQDEVDIMRRTTLLVFEILERAWQTKNCALIDM 195
            .|.|||||||:||||||||:::|.|:|.||.||:.|||||.::|:.:||:||:||.|::|.|:||
Zfish   126 MEMFFKDDANNDPQWSEEQLLAAGFDLAGLTIGRCEVDIMSKSTVAIFEVLEKAWATQDCTLVDM 190

  Fly   196 KVEFGI-CDDGNIVLADIIDSDSWRLWPAGDKRLMVDKQVYRNLASVTASDLDTVKRNFIWVAEQ 259
            |:|||: .....|||||:||:||||||||||:....||||||:|..||...:..|||||.||||:
Zfish   191 KIEFGVNVTTKEIVLADVIDNDSWRLWPAGDRSQQKDKQVYRDLKEVTPEAMQMVKRNFEWVAER 255

  Fly   260 LADIVPKKDH-LVVILMGSASDISHSEKIATSCRSLGLNVELRVSSAHKGPEETLRIVREYESVM 323
            :..::..:.. .||::|||.||::|.|||..:|.|.|:...|||:||||||:|||||..|||...
Zfish   256 VKLLLESQARGRVVVMMGSTSDVAHCEKIRKACASYGIPCHLRVNSAHKGPDETLRIKAEYEGDG 320

  Fly   324 SNLIFVAVAGRSNGLGPVVSGSTNYPVINCPPVKSDNMQVDVWSSLNLPSGLGCATVLYPEAAAL 388
            ...|||||||||||||||:||:|.|||||||||..|....|:||||.:||||||:|||.|||||.
Zfish   321 EPTIFVAVAGRSNGLGPVMSGNTAYPVINCPPVTPDWGAQDIWSSLRMPSGLGCSTVLSPEAAAQ 385

  Fly   389 HAATILGLGNFMVWSKLRVKALNNFITLKKADKELR 424
            .||.||||.|.::|:|||...||.:::||:|||:::
Zfish   386 FAAQILGLNNHLIWAKLRASMLNTWVSLKQADKKMQ 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Paics	NP_572826.1	SAICAR_synt_Ade5	12..260	CDD:133471	146/248 (59%)
Paics	NP_572826.1	purE	271..424	CDD:273474	96/152 (63%)
paics	NP_955831.1	SAICAR_synt_Ade5	7..258	CDD:133471	146/250 (58%)
paics	NP_955831.1	purE	268..421	CDD:273474	96/152 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583359
Domainoid	1	1.000	284	1.000	Domainoid score	I1597
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4710
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D307109at33208
OrthoFinder	1	1.000	-	-		FOG0004768
OrthoInspector	1	1.000	-	-		oto38781
orthoMCL	1	0.900	-	-		OOG6_101413
Panther	1	1.100	-	-	LDO	PTHR43599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1036
SonicParanoid	1	1.000	-	-		X3921
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880