DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Paics and ade7

DIOPT Version :9

Sequence 1:	NP_572826.1	Gene:	Paics / 32228	FlyBaseID:	FBgn0020513	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_595460.1	Gene:	ade7 / 2541029	PomBaseID:	SPBC409.10	Length:	299	Species:	Schizosaccharomyces pombe

Alignment Length:	289	Identity:	63/289 - (21%)
Similarity:	119/289 - (41%)	Gaps:	57/289 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVFRLLNEAGIRTAY 82
            |..||.:.:|:..|.|...|.::.|||:|.|.:..:.:..|.::....:...|.:| :..::|..
pombe    15 IATGKVRDLYECVEFPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVL-KPHVQTHL 78

  Fly    83 V--------------KQCGAKAFIARKCQMIPIEWVTRRLATGSFLK--------RNVGVPEGYR 125
            :              ::...::.:.:|.:::|||.:.|...|||..|        ..:.||.|.:
pombe    79 ITSRWEELPPVITKHEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLNVPTGMK 143

  Fly   126 FSPPKQETFF----KDDANHDPQWSEEQIVSAKFELNGLVIGQDEVDIMRRTTLLVFEILERAWQ 186
            .:....|..|    |....||.....:::        ..::|.:....:..|::.:::|......
pombe   144 EAEAFPEPLFTPSTKAAEGHDENIHPDEV--------SKIVGPELAKQVAETSVKLYKIARDVAL 200

  Fly   187 TKNCALIDMKVEFGICDDGN-IVLAD-IIDSDSWRLWPAGDKRL-----MVDKQVYRNLASVTAS 244
            .|...:.|.|.|||:.:..| |||.| ::..||.|.|.|.|..:     ..|||..||.  :||:
pombe   201 KKGIIIADTKFEFGVDETTNKIVLVDEVLTPDSSRFWLASDYTVGKSPDSFDKQYLRNW--LTAN 263

  Fly   245 DL-------------DTVKRNFIWVAEQL 260
            :|             :..:|.::...|.:
pombe   264 NLANKPNVSLPEDVVEATRRKYVEAYEMI 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Paics	NP_572826.1	SAICAR_synt_Ade5	12..260	CDD:133471	63/287 (22%)
Paics	NP_572826.1	purE	271..424	CDD:273474
ade7	NP_595460.1	SAICAR_synt_Sc	14..294	CDD:133469	63/289 (22%)
ade7	NP_595460.1	PRK13959	17..297	CDD:237570	62/287 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	55	1.000	Domainoid score	I3196
eggNOG	1	0.900	-	-		E1_COG0152
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	55	1.000	Inparanoid score	I2034
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto101538
orthoMCL	1	0.900	-	-		OOG6_101413
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1036
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790