|
Fly 555 ANANNMNHLPPH------PQQQHQQQQQQQQQHQAHQQQHQRSSPAQVQQQQQQQMNSSRQSH-- 611
|.:...:..||| |..:|||:........:|.:..|.|...|.|||||.:...|..|.
Human 12 AFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFH 76
Fly 612 --NDMCRQVVT---------TPMGMQLKVETLPQQQQKQQQHQQQQQQQQQQGRSQPVVSSMSTV 665
:|..::..| :|:.........|:.:|....|.|: ||:....
Human 77 PGSDRPQERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQR-------------VSAAVLP 128
Fly 666 VSQPVGTVTVTTAGLSAS------------HSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISPT 718
:..|: ..||.|| |...|..: :|...|:..:||
Human 129 LVHPL------PEGLRASADAKKDPAFGGKHEAPSSPI-SGQPCGDDQNAS-------------- 172
Fly 719 LPSDSSIEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKELND 783
||..| ||:|:..:.:||.||...|..:..|:||::.|.||| ||.....|.::
Human 173 -PSKLS---------KEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEA--AKPPEPEKPVS- 224
Fly 784 NNNDQEPMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQPLDV 848
.|.||...|| :.:.||..|||.|:..|.:.: .:..:..|||||||.|.
Human 225 -----PPPVEQKHRS--IVQIIYDENRKKAEEAHKIFE----------GLGPKVELPLYNQPSDT 272
Fly 849 EALAMLI-------RQHQSQI-RAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEAS 905
:.....| |..::|: |..|:|..::....|....|.:.::|.:....|:::.:|:|.:
Human 273 KVYHENIKTGVPARRMMKNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENN 337
Fly 906 AKRKAREAKNREFFEKVFTELRKQREDKERFNRVGSR--------IKSEADLEEIMDGLQEQALE 962
.:|||:|:|.||::||.|.|:|||||.:|||.|||.| .:||.::.||:|||.||...
Human 338 PRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENN 402
Fly 963 DKKMRSYAVIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKN 1027
:|:||..:||||:|.||.|||..:.|.|||:||.:.|::.|:.:|:||..|||.||:|::|||||
Human 403 EKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKN 467
Fly 1028 FGAIAASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGV 1092
||.||:.|:|||..|||.||||:||.||||.|:|::..:.|.......|:.:|.:.:.:......
Human 468 FGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQQIARPSQEEKVEEKEEDKA 532
Fly 1093 MTRLQREQQQKSGGRSSAVAERERAERAAERERVAEKAAADAAKAAESAAEKASAATKAVEATAA 1157
....::|:::|. |.|:.|:...:|...||...|. .||...|:. :||..
Human 533 EKTEKKEEEKKD--------EEEKDEKEDSKENTKEKDKIDG--TAEETEERE-------QATPR 580
Fly 1158 GEKVAKAAAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTASPATLAGIAADKTDAGK 1222
|.| ||.:........|.|.::.|::||.|:::
Human 581 GRK--------------TANSQGRRKGRITRSMTNEAAAASAAAAA------------------- 612
Fly 1223 TASASDKNAATAGGPTATGTPTAATTPATATAPPE-ISAGGEAKSKNAEEEAAATAGAATVATAG 1286
||..| |.....||| ||......|:..||| ..||..|
Human 613 ----------------ATEEP-----PPPLPPPPEPISTEPVETSRWTEEE-------MEVAKKG 649
Fly 1287 TPATGASAASAGEATTATGATATAAAKGV----------------GKPETATEP----------- 1324
....|.:.|:..: ..|..:.|..|.. .|.:|:.:|
Human 650 LVEHGRNWAAIAK---MVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCES 711
Fly 1325 -AGTAAKGADSRPDANDPLAKTASKAINAEGYNAIGGNSSSSSSNATGASAPVQGVTLNGFKPGY 1388
|.|.:...|...:| :::..|.| ::.|..:||.:.:|...| ||:.| ||
Human 712 VASTVSAQEDEDIEA-------SNEEENPE--DSEGAENSSDTESAPSPS-PVEAV-----KP-- 759
Fly 1389 QTVVMANVKASTGGDDSGANA---GGAAPGSLAATNASIATSGDKIVKTTPSSRAPNSTSSTAAN 1450
.:||..|| |...|..........|.| |:||...| |:..|.
Human 760 -------------SEDSPENATSRGNTEPAVELEPTTETAPS------TSPSLAVP---STKPAE 802
Fly 1451 ESSSGAGVNTYGHTATTAGNYLGQKLKAAQVEGLGAGNELHSDVSESKRKRFELNSGEAGG---- 1511
:.|....|| :.:.|......||.:.: :|.|.|.
Human 803 DESVETQVN----------------------DSISAETAEQMDVDQQE------HSAEEGSVCDP 839
Fly 1512 -NATSAMTNSSTSGSMNISNSHGLKA---NAKDGSMMAKTSMASTSSASVVVTSTPSASSSSLSS 1572
.||.| .|....:.:..:|..|. |.|:..:...:.........:||....:|......|
Human 840 PPATKA---DSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQS 901
Fly 1573 ASSMLLISAASVMSTAAGATSSSTATTTATASAISLPLLADGSGNSMVNANEILALDGKDKLASC 1637
.:.|:||.:|.......| ....:..:|.|..|.:
Human 902 -------------------DNDSSATCSADEDVDGEP-----------ERQRMFPMDSKPSLLN- 935
Fly 1638 FVCKAEACPRTRPLKKGRGQQYGIPDETIPAGARVCNSCQCKSVRSRYPNCPLPTCPNPKDRAQR 1702
|.|:.:.:| |..|||.|
Human 936 -----------------------------PTGSILVSS---------------PLKPNPLD---- 952
Fly 1703 LRNIPSRLFELAPEVRDPLMAEFQIPPHATRCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGD 1767
:|......| .|||..: |:.| |:..|
Human 953 ---LPQLQHRAA-----------VIPPMVS--CTPC------------NIPIG------------ 977
Fly 1768 ETDVSTSSCDEREPGGSDTASVESPENLQRHKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQP 1832
|.||..:. .||| :|...:....::|:|:|:|
Human 978 -TPVSGYAL------------------YQRH-----IKAMHESALLEEQRQRQEQ---------- 1008
Fly 1833 QPPPPAPQQQKGSSGRGGDQGTPLIITPTRMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSE 1897
|....|.|:. |....::|.:
Human 1009 ------------------------IDLECRSSTS----------------PCGTSKSPNR----- 1028
Fly 1898 EYDSSATETADEENENSPANRQSPKVLFHGHGHGHGGHANNVAGLQPPVANMGTGGGVQPGGAAG 1962
|::..: ||.| |.....
Human 1029 EWEGKS------------------------------------------VAYM-------PYAEVK 1044
Fly 1963 QQVNGPISMRREAVNNVQDCVFSVIERSLKHKGPQPKGGQGQQQGQGQGQGQGQGQTPGQSQSPS 2027
:.:.....|...|..:...|..| .|.:....|||
Human 1045 RALEQEAQMHNTAARSASPCRLS--PREVSKAAPQP----------------------------- 1078
Fly 2028 QQQQQQQQQQSANNLERKELTIVREYRQDPGILKQQQQQQQAGGAPPTSAAGSLPHGTSVQKLTT 2092
:::..| |...|.: |.| |.....:||.| |:..||
Human 1079 ------------------DMSAAR-YSVPPVL-------QPA----PHQVITNLPEG--VRLPTT 1111
Fly 2093 RPAAVAPPPPAHPLTPTSTG-------CAGS-NNGTSDSLATLSVVNSH-------------MGM 2136
|| ..||||..|.:.|:.. ..|| :.||..:..| || :|.
Human 1112 RP--TRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLT-----SHNQASYTQETPKPSVGS 1169
Fly 2137 VGIGHPGPMAHASSAGGIGVDKATITPVVKSSSGSSKSGGGSASSHSTATPPETIIYNVPVAHPQ 2201
:.:|.|.....|.|| ..|.:|....|.:|..............|.::.....|..:
Human 1170 ISLGLPRQQESAKSA---------TLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQE 1225
Fly 2202 ----RGIPPP--SQHSVHPAHPSHTQ-HPAHPQHSSHGQHTQLQVPEPEPQTLDLSIKKPPRDGH 2259
||.|.. |..|:.....|.|| .||.||... |....:..||.:.|.:..
Human 1226 GSITRGTPTSKISVESIPSLRGSITQGTPALPQTGI-----------PTEALVKGSISRMPIEDS 1279
Fly 2260 SPHTGAGGSSSSG----SGSGG-----PSSSDRHHGPPPP----TMSMKHIVRS--GGMYRGDTV 2309
||..|...::|.| .|..| .:..:...|...| .:|:|....| |.:.:|.::
Human 1280 SPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSM 1344
Fly 2310 TVPSLAAPSSYLYPTRSVKTIGGGGVVPGVLP-GVPGSALYLQPVPVPVPISISG---QGQLPPR 2370
....::||.. |::...|| |.|.|.|..:.| :|| || .||
Human 1345 RESPVSAPLE--------------GLICRALPRGSPHSDLKERTV-------LSGSIMQG--TPR 1386
Fly 2371 A-------GQPPPAQ-----PP----------------------SGRGVAKVPPKLSPQQAHHLH 2401
| |...|.| || .||.:.::|
Human 1387 ATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIP------------ 1439
Fly 2402 PSHGHSPSQQQQQQQQQQQQQQQQAAAAQQQLLVKSGSITHGTPA---NSAQQQIIVHAPATAAA 2463
:|....|:.::.....|....:..|||:.|||. |::.|..|.|...:...
Human 1440 ------------RQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLIT 1492
Fly 2464 APSSL---LSPKFDGLVRQTTPEGVGSVGPG-------GASGSGKHGSITQGTP------LHMPP 2512
.||.| :.| .:..||.:..|..| |.:...:|.|:....| ||..|
Human 1493 GPSKLSRGMPP------LEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAP 1551
Fly 2513 ---------HHLESKRPYESYYKSSQRHSP----------AQQPGGNQQ----LPPPPQQSSPQA 2554
....::|...||..:..|.|| :.....|.: |.|..::|.|..
Human 1552 KAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAK 1616
Fly 2555 PPPQGYGVGVS----------------------------SPYAR---------------SPFAGV 2576
.|..|....|| .|:.| ||..|.
Human 1617 SPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGY 1681
Fly 2577 VEQPQVL---STRQIVMHDYITSQQMQGQQQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESPSP 2638
..|.|:. :|||.:::|||||||| |...:.:::||. ||
Human 1682 PSQYQLYAMENTRQTILNDYITSQQM---------QVNLRPDVARGL----------------SP 1721
Fly 2639 RNSVGSASGFAYGGDKESAPRGRPEYSSRASPADHVNSTPS---PH----RTPPPQRQGVIQRHN 2696
|.. |.|.| |.:.....|..|..|: || .|||..|...|
Human 1722 REQ----------------PLGLP-YPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYI---- 1765
Fly 2697 TGSKPPSPAAPPPSRMHMPPYQYAPS----GHDALASFVDVAVQQPQLPVPSQKDDK-------- 2749
|.:::..||..|..: ||....:....|.::.:.....:::.:
Human 1766 -----------PGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSD 1819
Fly 2750 ---SPGPSTAPGQVPGS-GPPLGPSP----------LPPHAVVG-----VAQPPPPTAHHDQRYR 2795
.|| |..||: ||| |....||| ..|....| |..|..||| :.|
Human 1820 LYLRPG-SEQPGR-PGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTA----QLR 1878
Fly 2796 DLTLHHHHHTLVQQQIAQQQHYRSLNVAAQVDMQR---QMDQAKRVMRHQQHQVQQQQQQQQQQQ 2857
.:.|.....::.|...|.:.:..:..:||.||... |||.:| .::.:
Human 1879 IMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSK----------------TKESK 1927
Fly 2858 HNHALERDREMQERMRERDREREREREREQRERERERERERERERERREQDRARRVVAEEREHDS 2922
|..| .::|.:|.|......:::.||:..|.|:
Human 1928 HEAA-----RLEENLRSRSAAVSEQQQLEQKTLEVEK---------------------------- 1959
Fly 2923 RRMERMFAGNVVTGSGGAGGGGPSPGQFLRASV--PETGPPRSIPDRERESYYRQAHGGPAPEDT 2985
|.::.::. |.....|.|.| .:|| .|.|..:..|.:.|.....:..|...
Human 1960 RSVQCLYT------SSAFPSGKPQP----HSSVVYSEAGKDKGPPPKSRYEEELRTRGKTT---- 2010
Fly 2986 PGQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSGGGTGTRSS-----PA 3045
::|.:.||.||..:|....|| || |||.|...:.:.|| |:
Human 2011 ---ITAANFIDVIITRQIASDKDA-----RE-------------RGSQSSDSSSSLSSHRYETPS 2054
Fly 3046 NVLHPMYLRDLRQPLDGGAGSMLTAENNGKPSSSGSPSVINIDLDQERISAAAAAVAQQQQQQQA 3110
:.:..: .|:||.:|....:...|..:..|..|.....:|.:.
Human 2055 DAIEVI-----------------------SPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEG 2096
Fly 3111 P----PPSQSSQSRSVHGQLRTPTSQAGGSAPSPQQIHTKSITFGELTDSIITSDYGTN------ 3165
| .|.|.|.|.. |...|:|||.|....| :.| :.||..:....|||.|:..|
Human 2097 PLHHYRPQQESPSPQ---QQLPPSSQAEGMGQVP-RTH-RLITLADHICQIITQDFARNQVSSQT 2156
Fly 3166 PHLRPPYMAYLQETQSIL--PPDRWK-QNRRMQQKAEEAKHH----SQQQQQQQHQQQHHAQQQQ 3223
|. :||...: |.:.|.| .|.|.| .||...:...::.|| |:...:....:...::..:
Human 2157 PQ-QPPTSTF-QNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGK 2219
Fly 3224 QQQQQHHAQQHH-----PQMPG-----------TGSGSAPGGAGQGGGSGGPGSGGGGAGRASTP 3272
..::.|.:.:.: ||:|. :..|:.| |.|...:..|||
Human 2220 SPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEP--AEQRNDARSPGS----------- 2271
Fly 3273 GEDGRNIIRMP------QAVSPRKFNHEMMLHHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGG 3331
|..:| :..||...:.:..:...:.::|.|........|...:......|.||.
Human 2272 ------ISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGS 2330
Fly 3332 GGAPG--AGGPGSGGGATTIEKYVKTRI-----------AEVMRDDIGY---GKNRTV----EVR 3376
..:.| ...|.|..| :|..::..: ..||...:|. ..|.:| |.|
Human 2331 VSSRGHSFADPASNLG---LEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETR 2392
Fly 3377 TEDEVTADMVAHSHAAVHAAHVAHAAHVAHAAAMELQHRSKEPPPPEISVSRKTPNQYEVVDASG 3441
.|: .|...||........::.:. ..:||.|.|.:..:..:.|:....|.:.|
Human 2393 REE---GDPSPHSGGVCKPKLISKSN----------SRKSKSPIPGQGYLGTERPSSVSSVHSEG 2444
Fly 3442 --RRSAGSGSVSVSVSGANSHHSPYHPPAAAYAPSTYAFPYSALNVPGAAGGLPPHQPLQLAHQA 3504
.|.....:.....|...|...||:|.......||...|.:. .|.|.....|||..::..:.
Human 2445 DYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIAC--APSAVNQAAPHQQNRIWERE 2507
Fly 3505 VAP 3507
.||
Human 2508 PAP 2510
| 
