DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smr and NCOR1

DIOPT Version :9

Sequence 1:NP_001259491.1 Gene:Smr / 32225 FlyBaseID:FBgn0265523 Length:3607 Species:Drosophila melanogaster
Sequence 2:XP_005256923.1 Gene:NCOR1 / 9611 HGNCID:7672 Length:2524 Species:Homo sapiens


Alignment Length:3318 Identity:691/3318 - (20%)
Similarity:1061/3318 - (31%) Gaps:1184/3318 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   555 ANANNMNHLPPH------PQQQHQQQQQQQQQHQAHQQQHQRSSPAQVQQQQQQQMNSSRQSH-- 611
            |.:...:..|||      |..:|||:........:|.:..|.|...|.|||||.:...|..|.  
Human    12 AFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFH 76

  Fly   612 --NDMCRQVVT---------TPMGMQLKVETLPQQQQKQQQHQQQQQQQQQQGRSQPVVSSMSTV 665
              :|..::..|         :|:.........|:.:|....|.|:             ||:....
Human    77 PGSDRPQERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQR-------------VSAAVLP 128

  Fly   666 VSQPVGTVTVTTAGLSAS------------HSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISPT 718
            :..|:      ..||.||            |...|..: :|...|:..:||              
Human   129 LVHPL------PEGLRASADAKKDPAFGGKHEAPSSPI-SGQPCGDDQNAS-------------- 172

  Fly   719 LPSDSSIEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKELND 783
             ||..|         ||:|:..:.:||.||...|..:..|:||::.|.|||  ||.....|.:: 
Human   173 -PSKLS---------KEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEA--AKPPEPEKPVS- 224

  Fly   784 NNNDQEPMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQPLDV 848
                 .|.||...||  :.:.||..|||.|:..|.:.:          .:..:..|||||||.|.
Human   225 -----PPPVEQKHRS--IVQIIYDENRKKAEEAHKIFE----------GLGPKVELPLYNQPSDT 272

  Fly   849 EALAMLI-------RQHQSQI-RAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEAS 905
            :.....|       |..::|: |..|:|..::....|....|.:.::|.:....|:::.:|:|.:
Human   273 KVYHENIKTGVPARRMMKNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENN 337

  Fly   906 AKRKAREAKNREFFEKVFTELRKQREDKERFNRVGSR--------IKSEADLEEIMDGLQEQALE 962
            .:|||:|:|.||::||.|.|:|||||.:|||.|||.|        .:||.::.||:|||.||...
Human   338 PRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENN 402

  Fly   963 DKKMRSYAVIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKN 1027
            :|:||..:||||:|.||.|||..:.|.|||:||.:.|::.|:.:|:||..|||.||:|::|||||
Human   403 EKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKN 467

  Fly  1028 FGAIAASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGV 1092
            ||.||:.|:|||..|||.||||:||.||||.|:|::..:.|.......|:.:|.:.:.:......
Human   468 FGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQQIARPSQEEKVEEKEEDKA 532

  Fly  1093 MTRLQREQQQKSGGRSSAVAERERAERAAERERVAEKAAADAAKAAESAAEKASAATKAVEATAA 1157
            ....::|:::|.        |.|:.|:...:|...||...|.  .||...|:.       :||..
Human   533 EKTEKKEEEKKD--------EEEKDEKEDSKENTKEKDKIDG--TAEETEERE-------QATPR 580

  Fly  1158 GEKVAKAAAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTASPATLAGIAADKTDAGK 1222
            |.|              ||.:........|.|.::.|::||.|:::                   
Human   581 GRK--------------TANSQGRRKGRITRSMTNEAAAASAAAAA------------------- 612

  Fly  1223 TASASDKNAATAGGPTATGTPTAATTPATATAPPE-ISAGGEAKSKNAEEEAAATAGAATVATAG 1286
                            ||..|     |.....||| ||......|:..|||       ..||..|
Human   613 ----------------ATEEP-----PPPLPPPPEPISTEPVETSRWTEEE-------MEVAKKG 649

  Fly  1287 TPATGASAASAGEATTATGATATAAAKGV----------------GKPETATEP----------- 1324
            ....|.:.|:..:   ..|..:.|..|..                .|.:|:.:|           
Human   650 LVEHGRNWAAIAK---MVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCES 711

  Fly  1325 -AGTAAKGADSRPDANDPLAKTASKAINAEGYNAIGGNSSSSSSNATGASAPVQGVTLNGFKPGY 1388
             |.|.:...|...:|       :::..|.|  ::.|..:||.:.:|...| ||:.|     ||  
Human   712 VASTVSAQEDEDIEA-------SNEEENPE--DSEGAENSSDTESAPSPS-PVEAV-----KP-- 759

  Fly  1389 QTVVMANVKASTGGDDSGANA---GGAAPGSLAATNASIATSGDKIVKTTPSSRAPNSTSSTAAN 1450
                         .:||..||   |...|..........|.|      |:||...|   |:..|.
Human   760 -------------SEDSPENATSRGNTEPAVELEPTTETAPS------TSPSLAVP---STKPAE 802

  Fly  1451 ESSSGAGVNTYGHTATTAGNYLGQKLKAAQVEGLGAGNELHSDVSESKRKRFELNSGEAGG---- 1511
            :.|....||                      :.:.|......||.:.:      :|.|.|.    
Human   803 DESVETQVN----------------------DSISAETAEQMDVDQQE------HSAEEGSVCDP 839

  Fly  1512 -NATSAMTNSSTSGSMNISNSHGLKA---NAKDGSMMAKTSMASTSSASVVVTSTPSASSSSLSS 1572
             .||.|   .|....:.:..:|..|.   |.|:..:...:.........:||....:|......|
Human   840 PPATKA---DSVDVEVRVPENHASKVEGDNTKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQS 901

  Fly  1573 ASSMLLISAASVMSTAAGATSSSTATTTATASAISLPLLADGSGNSMVNANEILALDGKDKLASC 1637
                               .:.|:||.:|.......|           ....:..:|.|..|.: 
Human   902 -------------------DNDSSATCSADEDVDGEP-----------ERQRMFPMDSKPSLLN- 935

  Fly  1638 FVCKAEACPRTRPLKKGRGQQYGIPDETIPAGARVCNSCQCKSVRSRYPNCPLPTCPNPKDRAQR 1702
                                         |.|:.:.:|               |..|||.|    
Human   936 -----------------------------PTGSILVSS---------------PLKPNPLD---- 952

  Fly  1703 LRNIPSRLFELAPEVRDPLMAEFQIPPHATRCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGD 1767
               :|......|           .|||..:  |:.|            |:..|            
Human   953 ---LPQLQHRAA-----------VIPPMVS--CTPC------------NIPIG------------ 977

  Fly  1768 ETDVSTSSCDEREPGGSDTASVESPENLQRHKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQP 1832
             |.||..:.                  .|||     :|...:....::|:|:|:|          
Human   978 -TPVSGYAL------------------YQRH-----IKAMHESALLEEQRQRQEQ---------- 1008

  Fly  1833 QPPPPAPQQQKGSSGRGGDQGTPLIITPTRMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSE 1897
                                    |....|.|:.                |....::|.:     
Human  1009 ------------------------IDLECRSSTS----------------PCGTSKSPNR----- 1028

  Fly  1898 EYDSSATETADEENENSPANRQSPKVLFHGHGHGHGGHANNVAGLQPPVANMGTGGGVQPGGAAG 1962
            |::..:                                          ||.|       |.....
Human  1029 EWEGKS------------------------------------------VAYM-------PYAEVK 1044

  Fly  1963 QQVNGPISMRREAVNNVQDCVFSVIERSLKHKGPQPKGGQGQQQGQGQGQGQGQGQTPGQSQSPS 2027
            :.:.....|...|..:...|..|  .|.:....|||                             
Human  1045 RALEQEAQMHNTAARSASPCRLS--PREVSKAAPQP----------------------------- 1078

  Fly  2028 QQQQQQQQQQSANNLERKELTIVREYRQDPGILKQQQQQQQAGGAPPTSAAGSLPHGTSVQKLTT 2092
                              :::..| |...|.:       |.|    |.....:||.|  |:..||
Human  1079 ------------------DMSAAR-YSVPPVL-------QPA----PHQVITNLPEG--VRLPTT 1111

  Fly  2093 RPAAVAPPPPAHPLTPTSTG-------CAGS-NNGTSDSLATLSVVNSH-------------MGM 2136
            ||  ..||||..|.:.|:..       ..|| :.||..:..|     ||             :|.
Human  1112 RP--TRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLT-----SHNQASYTQETPKPSVGS 1169

  Fly  2137 VGIGHPGPMAHASSAGGIGVDKATITPVVKSSSGSSKSGGGSASSHSTATPPETIIYNVPVAHPQ 2201
            :.:|.|.....|.||         ..|.:|....|.:|..............|.::.....|..:
Human  1170 ISLGLPRQQESAKSA---------TLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQE 1225

  Fly  2202 ----RGIPPP--SQHSVHPAHPSHTQ-HPAHPQHSSHGQHTQLQVPEPEPQTLDLSIKKPPRDGH 2259
                ||.|..  |..|:.....|.|| .||.||...           |....:..||.:.|.:..
Human  1226 GSITRGTPTSKISVESIPSLRGSITQGTPALPQTGI-----------PTEALVKGSISRMPIEDS 1279

  Fly  2260 SPHTGAGGSSSSG----SGSGG-----PSSSDRHHGPPPP----TMSMKHIVRS--GGMYRGDTV 2309
            ||..|...::|.|    .|..|     .:..:...|...|    .:|:|....|  |.:.:|.::
Human  1280 SPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSM 1344

  Fly  2310 TVPSLAAPSSYLYPTRSVKTIGGGGVVPGVLP-GVPGSALYLQPVPVPVPISISG---QGQLPPR 2370
            ....::||..              |::...|| |.|.|.|..:.|       :||   ||  .||
Human  1345 RESPVSAPLE--------------GLICRALPRGSPHSDLKERTV-------LSGSIMQG--TPR 1386

  Fly  2371 A-------GQPPPAQ-----PP----------------------SGRGVAKVPPKLSPQQAHHLH 2401
            |       |...|.|     ||                      .||.:.::|            
Human  1387 ATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIP------------ 1439

  Fly  2402 PSHGHSPSQQQQQQQQQQQQQQQQAAAAQQQLLVKSGSITHGTPA---NSAQQQIIVHAPATAAA 2463
                        :|....|:.::.....|....:..|||:.|||.   |::.|..|.|...:...
Human  1440 ------------RQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLIT 1492

  Fly  2464 APSSL---LSPKFDGLVRQTTPEGVGSVGPG-------GASGSGKHGSITQGTP------LHMPP 2512
            .||.|   :.|      .:..||.:..|..|       |.:...:|.|:....|      ||..|
Human  1493 GPSKLSRGMPP------LEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAP 1551

  Fly  2513 ---------HHLESKRPYESYYKSSQRHSP----------AQQPGGNQQ----LPPPPQQSSPQA 2554
                     ....::|...||..:..|.||          :.....|.:    |.|..::|.|..
Human  1552 KAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAK 1616

  Fly  2555 PPPQGYGVGVS----------------------------SPYAR---------------SPFAGV 2576
            .|..|....||                            .|:.|               ||..|.
Human  1617 SPVPGVDPVVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGY 1681

  Fly  2577 VEQPQVL---STRQIVMHDYITSQQMQGQQQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESPSP 2638
            ..|.|:.   :|||.:::||||||||         |...:.:::||.                ||
Human  1682 PSQYQLYAMENTRQTILNDYITSQQM---------QVNLRPDVARGL----------------SP 1721

  Fly  2639 RNSVGSASGFAYGGDKESAPRGRPEYSSRASPADHVNSTPS---PH----RTPPPQRQGVIQRHN 2696
            |..                |.|.| |.:.....|..|..|:   ||    .|||..|...|    
Human  1722 REQ----------------PLGLP-YPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITYI---- 1765

  Fly  2697 TGSKPPSPAAPPPSRMHMPPYQYAPS----GHDALASFVDVAVQQPQLPVPSQKDDK-------- 2749
                       |.:::..||..|..:    ||....:....|.::.:.....:::.:        
Human  1766 -----------PGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSD 1819

  Fly  2750 ---SPGPSTAPGQVPGS-GPPLGPSP----------LPPHAVVG-----VAQPPPPTAHHDQRYR 2795
               .|| |..||: ||| |....|||          ..|....|     |..|..|||    :.|
Human  1820 LYLRPG-SEQPGR-PGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTA----QLR 1878

  Fly  2796 DLTLHHHHHTLVQQQIAQQQHYRSLNVAAQVDMQR---QMDQAKRVMRHQQHQVQQQQQQQQQQQ 2857
            .:.|.....::.|...|.:.:..:..:||.||...   |||.:|                .::.:
Human  1879 IMPLPAGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSK----------------TKESK 1927

  Fly  2858 HNHALERDREMQERMRERDREREREREREQRERERERERERERERERREQDRARRVVAEEREHDS 2922
            |..|     .::|.:|.|......:::.||:..|.|:                            
Human  1928 HEAA-----RLEENLRSRSAAVSEQQQLEQKTLEVEK---------------------------- 1959

  Fly  2923 RRMERMFAGNVVTGSGGAGGGGPSPGQFLRASV--PETGPPRSIPDRERESYYRQAHGGPAPEDT 2985
            |.::.::.      |.....|.|.|    .:||  .|.|..:..|.:.|.....:..|...    
Human  1960 RSVQCLYT------SSAFPSGKPQP----HSSVVYSEAGKDKGPPPKSRYEEELRTRGKTT---- 2010

  Fly  2986 PGQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSGGGTGTRSS-----PA 3045
               ::|.:.||.||..:|....||     ||             |||.|...:.:.||     |:
Human  2011 ---ITAANFIDVIITRQIASDKDA-----RE-------------RGSQSSDSSSSLSSHRYETPS 2054

  Fly  3046 NVLHPMYLRDLRQPLDGGAGSMLTAENNGKPSSSGSPSVINIDLDQERISAAAAAVAQQQQQQQA 3110
            :.:..:                       .|:||.:|....:...|..:..|..|.....:|.:.
Human  2055 DAIEVI-----------------------SPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEG 2096

  Fly  3111 P----PPSQSSQSRSVHGQLRTPTSQAGGSAPSPQQIHTKSITFGELTDSIITSDYGTN------ 3165
            |    .|.|.|.|..   |...|:|||.|....| :.| :.||..:....|||.|:..|      
Human  2097 PLHHYRPQQESPSPQ---QQLPPSSQAEGMGQVP-RTH-RLITLADHICQIITQDFARNQVSSQT 2156

  Fly  3166 PHLRPPYMAYLQETQSIL--PPDRWK-QNRRMQQKAEEAKHH----SQQQQQQQHQQQHHAQQQQ 3223
            |. :||...: |.:.|.|  .|.|.| .||...:...::.||    |:...:....:...::..:
Human  2157 PQ-QPPTSTF-QNSPSALVSTPVRTKTSNRYSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGK 2219

  Fly  3224 QQQQQHHAQQHH-----PQMPG-----------TGSGSAPGGAGQGGGSGGPGSGGGGAGRASTP 3272
            ..::.|.:.:.:     ||:|.           :..|:.|  |.|...:..|||           
Human  2220 SPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQRGAEP--AEQRNDARSPGS----------- 2271

  Fly  3273 GEDGRNIIRMP------QAVSPRKFNHEMMLHHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGG 3331
                  |..:|      :..||...:.:..:...:.::|.|........|...:......|.||.
Human  2272 ------ISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGS 2330

  Fly  3332 GGAPG--AGGPGSGGGATTIEKYVKTRI-----------AEVMRDDIGY---GKNRTV----EVR 3376
            ..:.|  ...|.|..|   :|..::..:           ..||...:|.   ..|.:|    |.|
Human  2331 VSSRGHSFADPASNLG---LEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETR 2392

  Fly  3377 TEDEVTADMVAHSHAAVHAAHVAHAAHVAHAAAMELQHRSKEPPPPEISVSRKTPNQYEVVDASG 3441
            .|:   .|...||........::.:.          ..:||.|.|.:..:..:.|:....|.:.|
Human  2393 REE---GDPSPHSGGVCKPKLISKSN----------SRKSKSPIPGQGYLGTERPSSVSSVHSEG 2444

  Fly  3442 --RRSAGSGSVSVSVSGANSHHSPYHPPAAAYAPSTYAFPYSALNVPGAAGGLPPHQPLQLAHQA 3504
              .|.....:.....|...|...||:|.......||...|.:.  .|.|.....|||..::..:.
Human  2445 DYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIAC--APSAVNQAAPHQQNRIWERE 2507

  Fly  3505 VAP 3507
            .||
Human  2508 PAP 2510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmrNP_001259491.1 GPS2_interact 710..798 CDD:292412 24/87 (28%)
TPH <725..1006 CDD:290579 103/296 (35%)
SANT 1009..1048 CDD:238096 25/38 (66%)
NCOR1XP_005256923.1 GPS2_interact 149..238 CDD:406267 32/123 (26%)
SANT 449..491 CDD:238096 28/41 (68%)
Myb_DNA-binding 637..680 CDD:395191 11/52 (21%)
MSCRAMM_ClfB <733..929 CDD:411414 51/288 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1878
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 346 1.000 Inparanoid score I2315
Isobase 1 0.950 - 0 Normalized mean entropy S7353
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001675
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR13992
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2297
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.990

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