Protein Alignment Smr and SNT1

DIOPT Version :10

• Sequence 1: NP_001259491.1
• Gene: Smr / 32225
• FlyBaseID: FBgn0265523
• Length: 3607
• Species: Drosophila melanogaster
• Sequence 2: NP_009962.2
• Gene: SNT1 / 850399
• SGDID: S000000629
• Length: 1226
• Species: Saccharomyces cerevisiae
• Alignment Length: 1309
• Identity: 231/1309 - (17%)
• Similarity: 397/1309 - (30%)
• Gaps: 440/1309 - (33%)

  Fly   440 HYASQPN-SNPSQQQQQQH--QQQQGGNPSGAGATSGAGGGGGGSGGSVMV-----GSLGRILMP 496
            ||::.|| .:||....:..  :....|..|...|.:........|..||.:     ||...|..|
Yeast    17 HYSNNPNRRHPSAVYSKNSFPKSSNNGFVSSPTADNSTNPSVTPSTASVPLPTAAPGSTFGIEAP 81

  Fly   497 HPQALQYTSEYLTNATAAVAAAMVNQRQHLQLQQQQQ-QQHPPEPFG-----------GQQPYKK 549
            .|.....:|....::::..:...:..|.:..:::... ....||...           |...|.:
Yeast    82 RPSRYDPSSVSRPSSSSYSSTRKIGSRYNPDVERSSSTTSSTPESMNTSTITHTNTDIGNSRYSR 146

  Fly   550 QRLSEAN-----ANNMNHLPPHPQQQHQQQQQQQQQHQAHQQQHQRSSPAQVQQQQQQQMNSSRQ 609
            :.:|..|     :.|:.|.|                     .....:.|..|.....::..|...
Yeast   147 KTMSRYNPQSTSSTNVTHFP---------------------SALSNAPPFYVANGSSRRPRSMDD 190

  Fly   610 SHNDMCRQVVTTPMGMQLKVETLPQQQQKQQQHQQQQQQQQQQGRSQPVVSSMSTVVSQP----- 669
            ...|:..::.|..:          ........|....:..:.:....|         |:|
Yeast   191 YSPDVTNKLETNNV----------SSVNNNSPHSYYSRSNKWRSIGTP---------SRPPFDNH 236

  Fly   670 VGTVTVT-----------------TAGLSASHSGSSGNV----------------AAGLGTGNTG 701
            ||.:|.|                 |..|.::||.||.::                :..:.|.:..
Yeast   237 VGNMTTTSNTNSIHQREPFWKANSTTILKSTHSQSSPSLHTKKFHDANKLDKPEASVKVETPSKD 301

  Fly   702 SASTEAYH-----PQVEAISPTLPSD--------------SSIEERGRTSAKE-----------D 736
            .....:||     |:.....|..|.:              ..:.:.||..|||           :
Yeast   302 ETKAISYHDNNFPPRKSVSKPNAPLEPDNIKVGEEDALGKKEVHKSGREIAKEHPTPVKMKEHDE 366

  Fly   737 LLMQIQKV--------DNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKEL------------ 781
            |..:.:||        .:||.:...|:.:..:..|...:|...:.|::.:.|:
Yeast   367 LEARAKKVSKINIDGKQDEIWTTAKTVASAVEVSKESQKELTRSVERKESPEIRDYERAYDPKAL 431

  Fly   782 ----------NDNNNDQEPMVELS-------------W------RSQMLAEKIYAANRKTAQAQH 817
                      |||.:.:||:.::.             |      |:::::|:.|
Yeast   432 KTDVTKLTVDNDNKSYEEPLEKVEGCIFPLPKAETRLWELKNQKRNKIISEQKY----------- 485

  Fly   818 SMLQNAAADESSPGSVAGRPWLPLYNQPLDVEALAMLIRQHQSQIRAPLLLHIRKLKAERWAHNQ 882
             :|:.|..:.|.         .|.|.|       ..||  ||......|...|.|:|.|......
Yeast   486 -LLKKAIRNFSE---------YPFYAQ-------NKLI--HQQATGLILTKIISKIKKEEHLKKI 531

  Fly   883 GLVEKYTKDQADWQRRCE----------RMEASAKRKAR---EAKNREFFEKVFTELRKQREDKE 934
            .|...|...|..:::.||          :.|...|||..   |.|.||  |.:.||  |::..:.
Yeast   532 NLKHDYFDLQKKYEKECEILTKLSENLRKEEIENKRKEHELMEQKRRE--EGIETE--KEKSLRH 592

  Fly   935 RFNRVGSRIKSEADLEEIMDGLQEQAL-----EDKKMRSYAVIPPLMHD-ARQRRCAYHNENGLI 993
            ..:...||.::.||.  :.|...|..|     ..|..::.|.||||:.| .|:....:.:.|.|:
Yeast   593 PSSSSSSRRRNRADF--VDDAEMENVLLQIDPNYKHYQAAATIPPLILDPIRKHSYKFCDVNNLV 655

  Fly   994 ED--MVAVHQQRKALNMWTAGEKETFKEKYLQHPKNFGAIAASL-DRKSPQDCVRYYYLSKKTEN 1055
            .|  :.|....:.|.:.:|..|...|.|.||.|||.||.|:..: ..:||::||.:||.:|||.|
Yeast   656 TDKKLWASRILKDASDNFTDHEHSLFLEGYLIHPKKFGKISHYMGGLRSPEECVLHYYRTKKTVN 720

  Fly  1056 YKQLL----RKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGVMTRLQREQQQKSGGRSSA------ 1110
            |||||    :|.:....:.|...|.::...:..:|.........:::|::.::....:.
Yeast   721 YKQLLIDKNKKRKMSAAAKRRKRKERSNDEEVEVDESKEESTNTIEKEEKSENNAEENVQPVLVQ 785

  Fly  1111 --------------------------VAERERAERAAERERVAEKAAADAAKAA----------- 1138
                                      ..|.|.|||..:.:|..::...::.|::
Yeast   786 GSEVKGDPLGTPEKVENMIEQRGEEFAGELENAERVNDLKRAHDEVGEESNKSSVIETNNGVQIM 850

  Fly  1139 -------------------------------ESAAEKASAATKAVEATAAGEKVAKAAAAAAAAA 1172
                                           :||.|..::.....|:....|.:.:..:..:..:
Yeast   851 DPKGAVQNGYYPEETKELDFSLENALQRKKHKSAPEHKTSYWSVRESQLFPELLKEFGSQWSLIS 915

  Fly  1173 ATTATTATTTTSS----------------STSSSSSSASSASTASS--------------STASP 1207
            ....|.:||...:                .|.......||.|...|              |...|
Yeast   916 EKLGTKSTTMVRNYYQRNAARNGWKLLVDETDLKRDGTSSESVQQSQILIQPERPNINAYSNIPP 980

  Fly  1208 ---ATLAGIAADKTDAGKTASASDKNAATAGGPT-ATGTPTAATTPATATAPPEISAGGEAKSKN 1268
               ..|.......|....|:.:|...:....||. ...|.:..:.|.|...||.:.:....:|:.
Yeast   981 QQRPALGYFVGQPTHGHNTSISSIDGSIRPFGPDFHRDTFSKISAPLTTLPPPRLPSIQFPRSEM 1045

  Fly  1269 AEEEAAATAGAATVATAGTPATGASAASAGEATTATGATATAAAKGVGKPETATEPAGTAAKGAD 1333
            ||                                                .|.|:        ..
Yeast  1046 AE------------------------------------------------PTVTD--------LR 1054

  Fly  1334 SRP-DANDPLAKTASKAINAEGY----NAIG-GNSSSSSSNATGAS------------------- 1373
            :|| |..|.||..||...|.:.:    |||. |..|::.||....|
Yeast  1055 NRPLDHIDTLADAASSVTNNQNFSNERNAIDIGRKSTTISNLLNNSDRSMKSSFQSASRHEAQLE 1119

  Fly  1374 --APVQGVTLNGFKPGYQTVVMANVKA----STGGDDSGANAGGAAPGSLAATNASIATSGDKIV 1432
              ..:..:.:...||...|...:::.|    ..|...|..:.....|...|.:..: .|......
Yeast  1120 DTPSMNNIVVQEIKPNITTPRSSSISALLNPVNGNGQSNPDGRPLLPFQHAISQGT-PTFPLPAP 1183

  Fly  1433 KTTPSSRAP 1441
            :|:|.||||
Yeast  1184 RTSPISRAP 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smr	NP_001259491.1	GPS2_interact	708..>776	CDD:464868	19/105 (18%)
		TPH	<725..1020	CDD:464007	79/375 (21%)
		Myb_DNA-binding	1009..1048	CDD:459731	16/39 (41%)
		Atrophin-1	<2187..>2323	CDD:460830
SNT1	NP_009962.2	PHA03255	62..>173	CDD:165513	18/131 (14%)
		Mitofilin	287..>587	CDD:430783	61/333 (18%)
		SANT	672..716	CDD:238096	18/43 (42%)
		RPN2	<715..803	CDD:227446	14/87 (16%)
		Myb_DNA-binding	892..933	CDD:459731	5/40 (13%)