Protein Alignment Smr and ncor1

DIOPT Version :9

• Sequence 1: NP_001259491.1
• Gene: Smr / 32225
• FlyBaseID: FBgn0265523
• Length: 3607
• Species: Drosophila melanogaster
• Sequence 2: XP_031751917.1
• Gene: ncor1 / 613105
• XenbaseID: XB-GENE-483288
• Length: 2526
• Species: Xenopus tropicalis
• Alignment Length: 3469
• Identity: 709/3469 - (20%)
• Similarity: 1132/3469 - (32%)
• Gaps: 1321/3469 - (38%)

  Fly   402 SSSGGGGGGGSAGGSAPPGGGVVQVSQSGGVLVMEAMPHYASQP--NSNPSQQQQQQHQQQQGGN 464
            ||||           .||..|.....|.          .|:|.|  .:.||.:.||:
 Frog     2 SSSG-----------YPPNQGAFSTEQG----------RYSSHPVQYTFPSSRHQQE-------- 37

  Fly   465 PSGAGATSGAGGGGGGSGGSVMVGSLGRILMPHPQALQYTSEYLTNATAAVAAAMVNQRQHLQLQ 529
                                          .|.|   :|.|.:|               :..||.
 Frog    38 ------------------------------FPVP---EYRSSHL---------------EASQLL 54

  Fly   530 QQQQQQHPPEPFGGQQPYKKQRLSEANANNMNHLPPHPQQQHQQQQQQQQQHQAHQQQHQRSSPA 594
            ||||.:..|           ..|||.:       |...:.|.::|..:||.|...|.:|
 Frog    55 QQQQLRRRP-----------SLLSEFH-------PVSDRPQDRRQGYEQQYHSVTQNEH------ 95

  Fly   595 QVQQQQQQQMNSSRQSHNDMCRQVVTTPMGMQLKVETLPQQQQKQQQHQQQQQQQQQQGRSQPVV 659
            :..:.::.:::.|...:......||  |:     |.|:.:..:.|.:.:::|
 Frog    96 EALESKRPRLDVSDSHYRVGAASVV--PL-----VPTIQEGVRVQSEVKKEQ------------- 140

  Fly   660 SSMSTVVSQPVGTVTVTTAGLSASHSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISPTLPSDSS 724
                               ||.:.|..:|..::...|.....|                 ||..|
 Frog   141 -------------------GLPSKHETTSSPLSGQPGEEQEAS-----------------PSKLS 169

  Fly   725 IEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKELNDNNNDQE 789
                     ||:|:..:.:||.||...|..:..|:||::.|.|||  ||.....|.::      .
 Frog   170 ---------KEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEA--AKPPEPEKPVS------P 217

  Fly   790 PMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWL--PLYNQPLDVEALA 852
            |.||...||  :.:.||..|||.|:..|.:|:..       |......:|  ||||||.|.:...
 Frog   218 PPVEQKHRS--IVQIIYDENRKKAEEAHKILEGL-------GPKVELSFLLQPLYNQPSDTKVYH 273

  Fly   853 MLIRQHQSQIRAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEASAKRKAREAKNRE 917
            ..|:.:| .:|..|:|..::....|....|.:.::|.:....|:::.:|:|.:.:|||:|:|.||
 Frog   274 ENIKTNQ-VMRKKLILFFKRRNHARKLREQNICQRYDQLMEAWEKKVDRIENNPRRKAKESKTRE 337

  Fly   918 FFEKVFTELRKQREDKERFNRVGSR--------IKSEADLEEIMDGLQEQALEDKKMRSYAVIPP 974
            ::||.|.|:|||||.:|||.|||.|        .:||.::.||:|||.||...:|:||..:||||
 Frog   338 YYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPP 402

  Fly   975 LMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKNFGAIAASLDRKS 1039
            :|.||.|||..:.|.|||:||.:.|::.|:.:|:||..|||.||||::|||||||.||:.|:||:
 Frog   403 MMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKEKFVQHPKNFGLIASYLERKT 467

  Fly  1040 PQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGVMTRLQREQQQKS 1104
            ..|||.||||:||.||:|.|:|::..:.|........:.||.:           ..:::.:::|:
 Frog   468 VSDCVLYYYLTKKNENFKALVRRNYPKRRGRNQQQITRPAQEE-----------KEIEKVEEEKA 521

  Fly  1105 GGRSSAVAERERAERAAERERVAE--KAAADAAKAAESAAEKASAATKAVE-ATAAGE---KVAK 1163
            ........||...|...|:|.:.:  |...||  .||...:|..:..:..: |.:.|.   ::.:
 Frog   522 ERNDKKEEERREEEEKEEKEELRDGTKDRTDA--IAEDGEDKEQSTPRGRKTANSQGRRKGRITR 584

  Fly  1164 AAAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTASPATLAGIAADKTDAGKTASASD 1228
            :.|:.|||||..|:||||..:::||         :||:::||:...:|....:.|
 Frog   585 SMASEAAAAANAASTATTAPATTTS---------TTATTTTAALVPVAPPPEEPT---------- 630

  Fly  1229 KNAATAGGPTATGTPTAATTPATATAPPEISAGGEAKSKNAEEEAAATAGAATVATAGTPATGAS 1293
                    |..|...|:|.|..|              |:..|||       ..||..|....|
 Frog   631 --------PPPTQEQTSADTVET--------------SRWTEEE-------MEVAKKGLVEHG-- 664

  Fly  1294 AASAGEATTATGATATAAAKGV----------------GKPETATEPAGTAAKGADSRPDANDPL 1342
             .:.|......|:.:.:..|..                .|.:::..|          |.:.:...
 Frog   665 -RNWGAIAKMVGSKSESQCKNFYFNYKRRHNLDNLLQQHKQKSSRRP----------REERDVSQ 718

  Fly  1343 AKTASKAINAEGYNAIGGNSSSSSSNATGASAPVQGVTLNGFKPGYQTVVMANVKASTGGDDSGA 1407
            .::.:..::|:      .:..:.:||..                       .|.:.|.|.::|..
 Frog   719 CESVASTVSAQ------EDEENEASNEE-----------------------ENAEDSEGAENSSD 754

  Fly  1408 NAGGAAPGSLAATNASIATSGDKIVKTTPSS---RAP--NSTSSTAANESSSGAGVNTYGHTATT 1467
            .....:|     :.|..|..||..|..|.||   .||  ...:|.:.::||....|.......|
 Frog   755 TESAPSP-----SPAEAAKLGDDAVDRTTSSVSIEAPPEQDAASKSVSDSSPTPTVENIKPPET- 813

  Fly  1468 AGNYLGQKLK---------AAQVEGLGAGNELHSDVSESKRKRFELNSGEAGGNATSAMTNSSTS 1523
              .|...|:|         |.:||....|.|:.|.:|...:.:.|.:..|           |..|
 Frog   814 --QYTELKVKEEISTETEEAMEVEERSQGAEIKSTLSLPVQTKAEPDEVE-----------SKPS 865

  Fly  1524 GSMNISNSHGLKANAKDGSMMAKTSMASTSSASVVVTSTPSASSSSLSSASSMLLISAASVMSTA 1588
            .|..:.    ::.:.||..|   ..:...:.|:.:|.:.|...|.....:.|
 Frog   866 ESAEVK----IEEDTKDQDM---ERLMDRAEATDMVYAPPLHISRGRQESQS------------- 910

  Fly  1589 AGATSSSTATTTATASAISLPLLADGSGNSMVNANEILALDGKDKLASCFVCKAEACPRTRPLKK 1653
               .:.|:||.:|.......|           ....|..||.|..|.:
 Frog   911 ---DNDSSATCSADEEVDGEP-----------ERPRIYTLDSKPSLLN----------------- 944

  Fly  1654 GRGQQYGIPDETIPAGARVCNSCQCKSVRSRYPNCPLPTCPNPKDRAQRLRNIPSRLFELAPEVR 1718
                         |||..:.:|    |::.           .|.| .|:|::..:
 Frog   945 -------------PAGTILISS----SMKQ-----------GPMD-LQQLQHRAA---------- 970

  Fly  1719 DPLMAEFQIPPHATRCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPGG 1783
                   .|||.|:  ||.|            |:|.|:|..:.......|.::.......:|...
 Frog   971 -------VIPPMAS--CSPC------------NITTGTSNFSMYQRHLYENNLLEEQRQRQEQLS 1014

  Fly  1784 SDTASVESPENLQRHKSL-----------TMVKQ--QQQQQQQQQQQQQQQQQQQQQQLSQPQP- 1834
            .::....||.|:.:..::           |.||:  :.:.|.|...:.....:...:::|:..|
 Frog  1015 LESRMSASPGNMSKSPNMDWEGKSVYMPYTEVKRAFEHEAQMQNVARSVSPYRLSPREVSRASPQ 1079

  Fly  1835 ----------PP---PAPQQQKGSSGRGG-------DQGTPLIITPTRMSSKSG------SGGAQ 1873
                      ||   |||.|...|...|.       .:..|.:|..::.|:.|.      :||:.
 Frog  1080 VDMNPARYCVPPVLQPAPHQVITSLSDGARLPVTRPTRPPPPLIPSSKTSATSSDKPSFITGGSI 1144

  Fly  1874 TAGD------------NERLLPPAAGQ----APKKQKTSEEYDSSATETADEENENSPANRQS-P 1921
            :.|.            ::..:.|:.|.    .|::|::::    :.:.|..::.|.||..:.| |
 Frog  1145 SQGTPGTYLTSLSQSYSQETVKPSVGSISLGLPRQQESAK----TGSVTYIKQEEFSPRGQSSQP 1205

  Fly  1922 KVLFHGHGHGHGGHANNVAGLQPPVANMGTG--GGVQPG----GAAGQQVNGPISMRREAVNNVQ 1980
            :.|.....|            :..|.::|||  ..:|.|    |....:|  ||    |||:.::
 Frog  1206 EGLLVRAQH------------EGVVRDVGTGTMTAIQEGSITRGTPATKV--PI----EAVSTLR 1252

  Fly  1981 DCVF------------------SVIERSLKHKGPQPKGGQGQQQGQGQGQGQGQ-GQTPGQSQSP 2026
            ..:.                  :.|.|........|:..:.:...:|....:|: |.......:.
 Frog  1253 GSITQGTPALSQSGIAADVLLKTTITRLATEDIGSPERCRDETSAKGHVIYEGKSGHIVSYDTAI 1317

  Fly  2027 SQQQQQQQQQQSANNLERKELTIVREYRQDPGILKQQQQQQQAGGAPPTSA--AGSLPHGTSVQK 2089
            ...::..:..::|     .|:|:.|.:....|.:||....::|..:.|...  ..:||.|::..:
 Frog  1318 KNMREGTRSPRTA-----PEVTLKRTFDTMEGNIKQAMSVREAAVSGPMEGLICRTLPKGSTHAE 1377

  Fly  2090 LTTRPAAVAPPPPAHPLTPTSTGCAGSNNGTSDSL-----------ATLSVVNSHMGMVGIGHP- 2142
            :..|...            :.:...|:...||||.           .....:.|..|.:..|.|
 Frog  1378 IKDRQVL------------SGSIMKGTPRTTSDSFEDGLKYAKQIKLESPPIRSFEGAISKGKPY 1430

  Fly  2143 ---------GPMAHASSAGGIGVDKATITPVVKSS----SGSSKSG---------GGSASSH--- 2182
                     |...|......:|..::..||  :||    .||...|         |.||..|
 Frog  1431 ECVTTIKEMGRSIHEIPRQDLGSQESRKTP--ESSRQIIEGSISQGTPIKYEGTSGQSAIKHNVK 1493

  Fly  2183 STATPPETIIYNVPVAHPQRGIPPPSQHSVHPAHPSHTQHPAHPQHSSHGQHTQLQVPEPEPQTL 2247
            |..|.|..:         .||:|               |....|::...|:.::.:
 Frog  1494 SLITGPSNL---------SRGLP---------------QMEVMPENLKMGERSKYE--------- 1525

  Fly  2248 DLSIKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHIVRSGGMYRGDTVTVP 2312
            |....:..|..|:...           |.|||                 ::||       |:...
 Frog  1526 DTKSSEAIRSRHTSVV-----------SSGPS-----------------VLRS-------TLHEA 1555

  Fly  2313 SLAAPSSYLYPTRSVKTIGGGGVVPGVLPGVPGSALYLQPVPVPVPISISGQGQLPPRAGQPPPA 2377
            |.:..|..:|...:.:.                     .||..|.|:|.|.
 Frog  1556 SKSQLSPGVYEDNNARR---------------------TPVNYPSPMSRSS-------------- 1585

  Fly  2378 QPPSGRGVAKVPPKLSPQQAHHLHPSHGHSPSQQQQQQQQQQQQQQQQAAAAQQQLLVKSGSITH 2442
              |..|. |:|  .|:|          |.|.|.:::
 Frog  1586 --PMARS-AEV--GLTP----------GKSSSHERK----------------------------- 1606

  Fly  2443 GTPANSAQQQIIVHAPA-----TAAAAPSSLLSPKFDGLVRQTTPEGVGSVGPGGASGSGKHGSI 2502
            .|...:.::.|:|.:|.     |||.:|       ||..:|...|                 |.:
 Frog  1607 STLTPTQRENIVVKSPVPGVDPTAAHSP-------FDPHLRGAPP-----------------GDV 1647

  Fly  2503 TQGTPLHMPPH---HLESKRPYESYYKSSQRHSPAQQPGG---NQQLPPPPQQSSPQAPPPQGYG 2561
            .:   .|:|||   .|:..||.:          ||.....   .:||.|.|..       |..|.
 Frog  1648 YR---THLPPHLDPALQFHRPLD----------PAAAAAAYLFQRQLSPTPGY-------PSQYQ 1692

  Fly  2562 VGVSSPYARSPFAGVVEQPQVLSTRQIVMHDYITSQQMQGQQQQQQQQQQQQRNMSRGSSASGGG 2626
            :     ||..            :|||.:::||||||||             |.|:
 Frog  1693 L-----YAME------------NTRQTILNDYITSQQM-------------QVNL---------- 1717

  Fly  2627 GGGGSDKESPSPRNSVGSASGFAYGGDKESAPRGRPEYSSRASPADHVNSTPSPHRTPPPQRQGV 2691
                                              ||:.:...||.|...:.|.      |..:|:
 Frog  1718 ----------------------------------RPDVARGLSPRDQGLAIPY------PGARGI 1742

  Fly  2692 IQRHNTGSKPPSPAAPPPSRMHMPPYQYAPSGHDALASFVDVAVQQPQLPVPSQKDDKSPGPSTA 2756
            |...|   .||:...|.|.....||.       |.:.
 Frog  1743 IDLTN---MPPAILVPHPGGTSTPPM-------DRIT---------------------------- 1769

  Fly  2757 PGQVPGSGPPLGPSPLPPHAVVGVAQPPPPTAHHDQRYRDLTLHHHHHTLVQQQIAQQQHYRSLN 2821
              .:||:.....|.|..|.::    .|..||                            |..:.|
 Frog  1770 --YIPGTQLAFPPRPYNPASM----SPGHPT----------------------------HLAAAN 1800

  Fly  2822 -VAAQVDMQRQMDQAKRVMRHQQHQVQQQQQQQQQQQHNHALERDREMQERMRERDRERERERER 2885
             |:|                                      ||:||     |||||||:||||:
 Frog  1801 SVSA--------------------------------------ERERE-----RERDRERDREREK 1822

  Fly  2886 EQRERERERERERERERERREQDRARRVVAEEREHDSRRMERMFAGNVVTGSGGAGGGGPSPGQF 2950
            |||||||:||||||            |:.|...:|..|.:...             .|.|....|
 Frog  1823 EQRERERDRERERE------------RLAAAPSDHYLRPVSEQ-------------PGRPGSHGF 1862

  Fly  2951 LRASVPETGPPRSIPDRERESYYRQAHGGP--APED---------TPGQLSAQSLIDAIIKHEIN 3004
            :|:..|......||. ::|.|.::..:|..  .|.|         |||   |.|:...|.....:
 Frog  1863 VRSPSPSVRAQESIM-QQRPSIFQGTNGKSVITPLDAAQLRIMPPTPG---AASITQGIPASRYS 1923

  Fly  3005 RSNDATA--------GPGREFPRP-SFVHAPL-----------------------------PPRG 3031
            .:.||.|        .|..|..:| ...|.|.                             .|..
 Frog  1924 TAADALAALVDAAASAPQMEVVKPKEMKHDPARSEESLSRRNVLEQQQQQQQIDCERRVMQSPYT 1988

  Fly  3032 SGSGGGTGTRSSPANVLH------------PMYLRDLRQP----------LDGGAGSMLTAENNG 3074
            |.|..|:.::..|:..::            ..|:.:||..          :|......:.::.:|
 Frog  1989 SSSFSGSKSQGQPSPAVYSEAGKEKTAHTKSRYVEELRMRGKTTITAANFIDVIITQQIASDKDG 2053

  Fly  3075 K------PSSSGSPSVINIDLDQERISAAAAAVAQQQQQQQAPPP-SQSSQ------SRSVHGQL 3126
            :      ..||.|.|....|..::.|...:.|.:..|:::..||. .:|||      ||...||.
 Frog  2054 RDRNSQSSDSSSSHSSHRYDAPRDTIEVISPANSPVQEKESYPPEIPKSSQTETGESSRKYEGQP 2118

  Fly  3127 RTPTSQAGGSAPSPQQI---HT----KSITFGELTDSIITSDYG----TNPHLRPPYMAYLQETQ 3180
            .....|.  .:|||||.   |.    :.||..:....|||.|:.    .|..|:.|..:..|.|.
 Frog  2119 NRYRQQQ--ESPSPQQTIPGHVPQTHRLITLADHICQIITQDFARNQPVNQALQQPPASTFQSTN 2181

  Fly  3181 SILPPDRWKQNRRMQQKAEEAKHHSQQQQQQQHQQQ----------------H------------ 3217
            ....|.|.|.:.|...:::....|:|:...:...:.                |
 Frog  2182 PSSTPVRTKASSRFSPESQVQPVHNQRPASRVSPENVLDRPRGRPGKSPDRGHISEPYEPISPPQ 2246

  Fly  3218 ----HAQQQQ----QQQQQHHAQQHHPQMPG--------------------------------TG 3242
                ||:|..    .|:|:...|::..:.||                                :|
 Frog  2247 APLLHAKQDSMLLLSQRQEPPEQRNDSRSPGNISYLPSFFTKLENTSPMVMYKKQEIFRKLNSSG 2311

  Fly  3243 SGSAPGGAGQGG----------GSGGPGSGGGG-AGRASTPG-EDGRNIIRMPQAVSPRKFNHEM 3295
            .|.:...|.|.|          .||...|.|.. |..||..| ||   |||  :|:. ..|:.:.
 Frog  2312 GGDSEMAAAQPGTEIFNLPAVTTSGAISSRGHSFADPASNLGLED---IIR--KALM-GNFDDKS 2370

  Fly  3296 MLHHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGGGGAPGAGGPGSGGGATTIEKYVKTRIAEV 3360
            ..|.|:.....|..:|.....:|    .:...||          |.|||| |..:|.:..
 Frog  2371 EDHSVLVGVAQGNPSGTQNSEAR----REEANPS----------PNSGGG-THKQKLISK----- 2415

  Fly  3361 MRDDIGYGKNRTVEVRTEDEVTADMVAHSHAAVHAAHVAHAAHVAHAAAMELQHRSKEPPPPEIS 3425
                  ||..:|                                            |.|    ||
 Frog  2416 ------YGSRKT--------------------------------------------KSP----IS 2426

  Fly  3426 VSR-----KTPNQYEVVDASG-RRSAGSGSVSVSVSGANSHHSPYHPPAAAYAPSTYAFPYSALN 3484
            .|:     :.|:....|.:.| .|.|.:.:.....|...|...||:|.......||   |.|:::
 Frog  2427 GSQTYLGAERPSSVSSVHSEGDYRQASAWAWEDRPSSTGSTQFPYNPLTMGMLNST---PPSSMS 2488

  Fly  3485 -VPGAAGGLPPHQPLQLAHQAVAP 3507
             .|.:......||..::..:..||
 Frog  2489 CAPTSMTQTSAHQQSRIWEREPAP 2512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smr	NP_001259491.1	GPS2_interact	710..798	CDD:292412	24/87 (28%)
		TPH	<725..1006	CDD:290579	104/290 (36%)
		SANT	1009..1048	CDD:238096	25/38 (66%)
ncor1	XP_031751917.1	GPS2_interact	145..230	CDD:406267	30/120 (25%)
		SANT	437..479	CDD:238096	28/41 (68%)
		Myb_DNA-binding	647..690	CDD:395191	10/52 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1716
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001675
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13992
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2297
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.180