DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smr and ncor2

DIOPT Version :9

Sequence 1:NP_001259491.1 Gene:Smr / 32225 FlyBaseID:FBgn0265523 Length:3607 Species:Drosophila melanogaster
Sequence 2:XP_009302460.1 Gene:ncor2 / 561503 ZFINID:ZDB-GENE-030616-81 Length:2379 Species:Danio rerio


Alignment Length:3378 Identity:686/3378 - (20%)
Similarity:1036/3378 - (30%) Gaps:1308/3378 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   536 HPPEPFGGQQPYKKQRLSEANANNMNHLPPHPQ-----QQHQQQQQQQQQHQAHQQQHQRSSPAQ 595
            ||.....|::....:.||.| ||....|..|..     ..|...:.....|.:..|.|:| .|:.
Zfish     4 HPQPVPQGRRAVDARHLSSA-ANLPLQLRAHTDVGGLVDYHPHARDYGLTHGSLVQPHRR-RPSL 66

  Fly   596 VQQQQQQQMNSSRQSHNDMCRQVVTTPMGMQLKVETLPQQQQKQQQHQQQQQQQQQQGRSQPVVS 660
            :.:.|.   .:.|:.|               ::.|.:..|....|...:..:.::.:     :..
Zfish    67 LSEFQP---GNEREPH---------------IRYEHIYLQDASSQSEVEYSEMKRPR-----LEI 108

  Fly   661 SMSTVVSQPVGTVTVTTAG---LSASHSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISPT--LP 720
            ...:::........:|..|   ::..||.||     .:|              ::|.|||.  :|
Zfish   109 GAESLIRHSSHRQALTVGGAEEMAKEHSSSS-----SIG--------------KIEPISPVSPVP 154

  Fly   721 SDSSIEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKELNDNN 785
            .::.::......:||:|:..:.:||.||...|..:..||||::.|.|||  ||.|...:.::   
Zfish   155 MEADLDLVPSRLSKEELIQNMDRVDREITMVEQQISKLRKKQQQLEEEA--AKPQEPERTIS--- 214

  Fly   786 NDQEPMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQPLDVEA 850
               .|..|...||  |.:.||..|||.|:..|.:|:          .:..|..|||||||.|.:.
Zfish   215 ---PPPSEAKHRS--LVQIIYDENRKKAEEAHRILE----------GLGPRVELPLYNQPSDTKQ 264

  Fly   851 LAMLIRQHQSQIRAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEASAKRKAREAKN 915
            ....|:.:|: :|..|:|:.::....|....|...::|.:....|:::.||:|.:.:|:|:|:|.
Zfish   265 YHENIKINQA-MRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKV 328

  Fly   916 REFFEKVFTELRKQREDKERF-NRVGSR-------IKSEADLEEIMDGLQEQALEDKKMRSYAVI 972
            ||::||.|.|:|||||.:||. |||..|       .:||.::.||:||:.||...:|:||..|||
Zfish   329 REYYEKQFPEIRKQRELQERMQNRVAQRGGGLASAARSEHEVSEIIDGISEQENSEKQMRQLAVI 393

  Fly   973 PPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKNFGAIAASLDR 1037
            ||::.||.|:|..:.|.|||::|.:.|::.|:.:|||:..||:||:||::||||||..||:.|:|
Zfish   394 PPMLFDAEQQRIKFINMNGLMDDPMKVYKDRQVMNMWSEQEKDTFREKFIQHPKNFALIASFLER 458

  Fly  1038 KSPQDCVRYYYLSKKTENYKQLLRKS-RQRTRSSRNPAKAQAAQPQCIIDSMTTGVMTRLQREQQ 1101
            |:..:||.:|||:||.||||.::|:| |:|.||..|    |.||.|             :.|..|
Zfish   459 KTVAECVLFYYLTKKNENYKNIVRRSYRRRGRSQNN----QQAQQQ-------------VNRNNQ 506

  Fly  1102 QKSGGRSSAVAERERAERAAERERVAEKAAADAAKAAESAAEKASAATKAVEATAAGEKVAKAAA 1166
            :          |:|..|:..|.||..:||..|                                 
Zfish   507 E----------EKEDKEKEKEGEREEDKAEGD--------------------------------- 528

  Fly  1167 AAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTASPATLAGIAADKTDAGKTASASDKNA 1231
                                                             ||.|..|..::.:...
Zfish   529 -------------------------------------------------DKEDGIKDDTSGEDGE 544

  Fly  1232 ATAGGPTATGTPTAATTPATATAPPEISAGGEAKSK------NAEEEAAATAGAATVATAGTPAT 1290
            ......|..|..||             ::.|..|.:      |.:||..:..|:   ..|.....
Zfish   545 EKEPPVTVKGRRTA-------------NSRGHRKGRVTRSMTNEQEENTSPLGS---ELANLEMN 593

  Fly  1291 GASAASAGEATTAT------GATATAAAKGVGKPETATEPAGTAAKGADSRPDANDPLAKTASKA 1349
            .:|..:..|..||.      |...:|.||.||                          :||.|:.
Zfish   594 ESSRWTEEEMETAKKGLLQYGRNWSAIAKMVG--------------------------SKTVSQC 632

  Fly  1350 INAEGYNAIGGNSSSSSSNATGASAPVQGVTLNGFKPGY-------QTVVMANVKASTGGDDSGA 1407
            .|                                |...|       :.:....:|:.   .:..|
Zfish   633 KN--------------------------------FYFNYKKRQKLDEILQQHKIKSE---KERKA 662

  Fly  1408 NAGGAAPGSLAATNASIATSGDKIVKTTPSSRAPNSTSSTAANESSSGAGVNTYGHTATTAGNYL 1472
            ...|.||.:..|                       |..|.|..|...|:||              
Zfish   663 RRKGKAPQNEEA-----------------------SAPSAAEEEEMEGSGV-------------- 690

  Fly  1473 GQKLKAAQVEGLGAGNELHSDVSESKRKRFELNSGEAGGNATSAMTNSSTSGSMNISNSHGLKAN 1537
                         :|||..:.           ..||.|.|      |||.:.|:           
Zfish   691 -------------SGNEEEAQ-----------EDGEGGAN------NSSDTESL----------- 714

  Fly  1538 AKDGSMMAKTSMASTSSASVVVTSTPSASSSSLSSASSMLLISAASVMSTAAGATSSSTATTTAT 1602
                                     ||..||..|....    ..::...||..|||||::|....
Zfish   715 -------------------------PSPRSSDDSKVKE----EGSARPKTAPNATSSSSSTDKDM 750

  Fly  1603 ASAISLPLLADGSGNSMVNANEILALDGKDKLASCFVCKAEACPRTRPLKKGRGQQYGIPDETIP 1667
            |:|.:                   .:|.|.|                 ::||.|:|.|:..|.  
Zfish   751 AAAET-------------------GMDEKPK-----------------VEKGDGEQAGVKQEV-- 777

  Fly  1668 AGARVCNSCQCKSVRSRYPNCPLPTCPNPKDRAQRLRNIPSRLFELAPEVRDPLMAEFQIPPHAT 1732
                                                                             
Zfish   778 ----------------------------------------------------------------- 777

  Fly  1733 RCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPGGSDTASVESPENLQR 1797
                        |.:|        ..||...:|.|:                             
Zfish   778 ------------KTEP--------GEGASESAGEDK----------------------------- 793

  Fly  1798 HKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQPQPPPPAPQQQKGSSGRGGDQGTPLIITPTR 1862
                                                 .|||.:.::|.                :
Zfish   794 -------------------------------------KPPALEVEEGK----------------K 805

  Fly  1863 MSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSEEYDSSATETADEENENSPANRQSPKVLFHG 1927
            ...|...||...|.|:                     |||||.:|||..|...:.:..|.:|...
Zfish   806 EVKKKEHGGKSGAHDS---------------------DSSATCSADEVEETESSEKSRPSLLSFS 849

  Fly  1928 HGHGHGGHANNVAGLQ---------PPVANMGTGGGVQPGGAAGQQVNGPISMRREAVNNVQDCV 1983
            |.......|.....|:         ||:....:|...:||....|.:...:::.::.:       
Zfish   850 HDGVISSQAQKPLDLKQLKQRAAAIPPILPEVSGRDNRPGLPGKQAMPDALALYQQQI------- 907

  Fly  1984 FSVIERSLKHKGPQPKGGQGQQQGQGQGQGQGQGQTPGQSQSPSQQQQQQQQQQSANNLERKELT 2048
                  ::.|                            :|...::||||||..:|.:.....:..
Zfish   908 ------TMAH----------------------------ESSQEAKQQQQQQPTKSQHYPAAGDSG 938

  Fly  2049 IVREYRQDPGILKQQQQQQQAGGAPPTSAAGSLPHGTSVQKLTTRPAAVAPPPPAHPLTPTSTGC 2113
            ..|...:.|||..:::::.:..    .....:|.||                  .|.....|...
Zfish   939 SPRVRTRSPGISDREREELEGN----ERWLQALLHG------------------LHKSRAFSPLA 981

  Fly  2114 AGSNNGTSDSLATLSVVNSHMGMVGIGHPGPMAHASSAGGIGVDKATITPVVKSSSGSSKSGGGS 2178
            .|..|..:|.:..|          |:|.|             |..:.::|...:.....:....:
Zfish   982 DGKKNPGADDIRAL----------GLGRP-------------VMSSYLSPRDMAKFSQEQLLHYN 1023

  Fly  2179 ASSHSTATPPETIIYNVPVAHPQRGIPPPSQHSVHPAHPSHTQHPAHPQHSSHG-QHTQLQVPEP 2242
            .|..||..|.:.:....|:..|:   |||...|..|........|....:.||| :|.::    |
Zfish  1024 PSLASTLQPQDRMAAVRPLHIPE---PPPLISSAKPGGSITQGTPVQLHNPSHGSEHGKV----P 1081

  Fly  2243 EPQTLDLSIKKPPRDGHSP-----HTGAGGSSSSGSGSGGPSSSD--RHHGPPPPTMSMKHIVRS 2300
            .|.:|.||.....:.|..|     .....|:|||.|.:...|:.|  ...||.|       .|:.
Zfish  1082 APGSLALSWVDQRKMGGFPVVKQEQLSPRGASSSSSQAENLSTQDSSTSRGPMP-------AVQG 1139

  Fly  2301 GGM----------------YRGDTVTVPSLAAPSSYLY------------PTRS---VKTIGGGG 2334
            |.:                |||.::|   ...|:..||            |:|.   ..|...|.
Zfish  1140 GSITKGIPGTRVHQDSPISYRGGSIT---QGTPADVLYKGTITRLINEDSPSRERSREDTPSKGH 1201

  Fly  2335 VVPGVLPGVPGSALYLQPVPVPVPISISGQGQLPPR---------AGQPPPAQPPSGRGV---AK 2387
            |   |..|:.|..|..:..|..........|....|         :.:.||.:.|...|:   |.
Zfish  1202 V---VYEGISGHILSFERRPNSKEEGCGDVGAGMKRSYDMMEVGISSRVPPIRDPLSEGLIIRAM 1263

  Fly  2388 VPPKLSPQQAHHLHPSHGHSPSQQQQQQQQQQQQQQQQAAAAQQQLLVKSGSITHGTPANSAQQQ 2452
            .|.:.||      ||                             ||:  .|||:.|.|.:..|::
Zfish  1264 PPDRDSP------HP-----------------------------QLI--RGSISQGIPRDDCQRR 1291

  Fly  2453 IIVHAPATAAAAP-------SSLLSPKFDGLVRQTTPEGVGSV----GPGGASGSGKHGSITQGT 2506
            .:.......:.:|       .:|.|...:.:| .|..||..|:    ..|...|..|.|||||||
Zfish  1292 EVKQMKREGSPSPRGPGHSTDALKSRSHESMV-PTVKEGGRSIHLIPPEGVVIGKPKEGSITQGT 1355

  Fly  2507 PLHMPPHHLESKRPYESYYKSSQRHSPAQQPGGNQQLPPPPQQSSPQAPPPQGYGVGVSSPYARS 2571
            ||...|.            .||:||...                          .:..|||   .
Zfish  1356 PLKQEPP------------GSSKRHDVR--------------------------SIIASSP---R 1379

  Fly  2572 PFAGVVEQPQVLSTRQIVMHDYITSQQMQGQQQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESP 2636
            |::|:   |..|.                                .|||..:.....||..:.|.
Zfish  1380 PYSGL---PSHLD--------------------------------PRGSDRARYEEAGGKSRPSA 1409

  Fly  2637 --SPRNSVGSASGFAYGGDKESAPRGRPEYSSRASPADHVNST--PSPHRTPPPQRQGVIQRHNT 2697
              |..:|:...|..|..|::.|.|...|     ....||..|:  |..||..|...:...||.:.
Zfish  1410 VVSAPSSLSRVSPLALSGEQSSRPHHSP-----VGYEDHKRSSYPPPSHRASPLSGRENSQRAHE 1469

  Fly  2698 GSKPPS----PAAPPPSRMHMPPYQYAPSGHDALASFVDVAVQQPQLPVPSQKDDKSPGPSTAPG 2758
            ||..|.    .|.|.|..|.......|...|.|..:|..:....|.: ..||....:...:..|.
Zfish  1470 GSSKPQQQERKATPTPREMGSTKSPLAVGEHTANLAFERILGLGPDM-YRSQMSHLTFDAAALPR 1533

  Fly  2759 QVP-----------GSGPPLGPSPLPPHAVVGVAQPPPPTAHHDQRYRDLTLHHHHHTLVQQQIA 2812
            .:|           ..||.. |.|.||:.:.|..   |.||..:.|          .||....|.
Zfish  1534 GIPIDSAYYLPRHLAPGPGY-PHPYPPYLIRGCF---PETAALENR----------QTLFNDYIT 1584

  Fly  2813 QQQHYRSLNVAAQVDMQRQMDQAKRVMRHQQHQVQQQQQQQQQQQHNHALERDREMQ-------- 2869
            .||.::....||   |..|.....|.:..::..:........:......::|...:.        
Zfish  1585 SQQMHQWPAAAA---MAAQRPDLLRGLTPREQSLNLAYSPTPRGTSASPMDRITYIPGTSPGFPS 1646

  Fly  2870 ----------------------ERMRERDREREREREREQRERERERERERERERERREQDRARR 2912
                                  ....||:||||||||||||||||||||||:|||:|   ||.|.
Zfish  1647 GAYNTSPISPVGASHMSKIQGGSSSAEREREREREREREQRERERERERERDRERDR---DRERE 1708

  Fly  2913 VVAEEREHDSRRMERMFAGNV-------------VTGSGGAGGGGP-------SP---------- 2947
               ::|:.|..|.:.:..|||             ::||.......|       ||          
Zfish  1709 ---KDRDRDRERDKSLSHGNVEHAPIWRPGAPEQMSGSSSRPPSHPYSHQSPLSPRPQDSLQQRP 1770

  Fly  2948 ----------------------------------GQFLRASVPETGPPR----SIPDRERESYYR 2974
                                              |...|:.:|..|.|.    |..|..|:....
Zfish  1771 SVLHNTSSKSLSNSEHNNPSVLRPPGSARYQGFSGHLQRSGLPGEGYPSGTDPSAKDLSRDGGKS 1835

  Fly  2975 QAHGG-PAPEDTPGQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSGGGT 3038
            ...|| |..:|    ||:.|..|         |..|:.|.|..:|.| :..||:....:..|   
Zfish  1836 HGRGGLPKHQD----LSSSSKSD---------SKLASPGAGGTYPSP-YNQAPVAHLPTSRG--- 1883

  Fly  3039 GTRSSPANVLHPMYLRDLRQPLDGGAGSMLTAENNGKPSSSGS-----PSVINID------LDQE 3092
                      ||     |..|..||.||.:.:......||:.|     ..|::|.      |.:.
Zfish  1884 ----------HP-----LLAPESGGGGSSIQSRGGDSGSSASSREKTQNKVMSIQEHELRALGKT 1933

  Fly  3093 RISAA------------------------------AAAVAQQQQQQQAPPPSQSSQSRSVHGQLR 3127
            .::||                              |.:.|||:..:|.    ..|:.|...||  
Zfish  1934 TMTAANFINAIIMHQISCDAAMPETGALATNGTCDAVSAAQQKAFEQL----YGSEDRLSPGQ-- 1992

  Fly  3128 TPTSQAGGSAPSPQQIHTKSITFGELTDSIITSDY---------GTNPHLRPPYMAYLQETQSIL 3183
                |:.......|::    :|..:....:||.||         |..|.| ||...|  .:..:|
Zfish  1993 ----QSSSGVKGSQRV----VTLAQHISEVITKDYTRQSQQNQIGGQPSL-PPGYGY--HSSPVL 2046

  Fly  3184 PPDRWKQNRRMQQKAEEAKHHSQQQQQQQHQQQHHAQQQQQQQQQHHAQQHHPQMP--GTGSGSA 3246
            ...|.....:.|...|....::.:....:..:.....|.:.......|....|..|  .......
Zfish  2047 DLTRPPSTPQAQTPTEPNSRYTPEGTSAERGRDRSPPQNKTSPVSLAADGIEPVSPPGAISEPET 2111

  Fly  3247 PGG------AGQGGGSGGPGSGGGGAGRASTPGEDGRNIIR----MPQAVSPR-KFNHEM---ML 3297
            ||.      |.||.||..|.|........|...|....|::    |.:.:|.. :||...   .:
Zfish  2112 PGANYPNEQAEQGMGSRSPASSSQPPAFFSKLTESNSAIVKSKKEMIKKISAEAEFNQSQPGTEI 2176

  Fly  3298 HHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGGGGAPGAGGPGSGGGATTIEKYVKTRIAEVMR 3362
            .::..:|.||        |..|     |..|.          |.:.|....:|..::..:     
Zfish  2177 FNMPVSTNAG--------PVSV-----RSHPP----------PEASGNTIGLEAIIRKAL----- 2213

  Fly  3363 DDIGYGK-NRTVEVRTEDEVTADMVAHSHAAVHAAHVAHAAHVAHAAAMELQHRSKEPPPPEISV 3426
                .|| :..::.|:.......|.|...|||          |..|:|   ..||::|       
Zfish  2214 ----MGKYDEQMDERSPSNSVNSMAAGGAAAV----------VPPASA---DGRSEDP------- 2254

  Fly  3427 SRKTPNQYEVVDASGRRSAGSG----------SV-SVSVSGANSHHSPYHPPAAAYAPSTYAFPY 3480
             ...|.:.:...::||::...|          || ||...|..:.|:|.........||      
Zfish  2255 -YSLPGKSKGGRSNGRKTKSPGPGLSGGERPSSVSSVHSEGDCNRHTPLTNRVWEDRPS------ 2312

  Fly  3481 SALNVPGAAGGLP-PHQPLQLAHQAVAPPGAFAKAKAAHALSELGAVGGGVSLVVGGGSGGIAGG 3544
                   :.|..| |..||.:                            |:.|     ..||..|
Zfish  2313 -------STGPTPFPCNPLTM----------------------------GMRL-----PSGIMPG 2337

  Fly  3545 PGGVSVGVGVPGGGGPGSGGGGGGGHNSSSSQASAAVAAAVAAAASESKPLLLSKYDALSDED 3607
            |   |.....||...|..|                  .........|.||||.|:|:.|||.:
Zfish  2338 P---SPSPTHPGASAPTQG------------------QTQPRTWEEEPKPLLCSQYETLSDSE 2379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmrNP_001259491.1 GPS2_interact 710..798 CDD:292412 26/89 (29%)
TPH <725..1006 CDD:290579 101/288 (35%)
SANT 1009..1048 CDD:238096 20/38 (53%)
ncor2XP_009302460.1 GPS2_interact 142..227 CDD:318079 30/108 (28%)
SMC_N <167..456 CDD:330553 118/309 (38%)
SWIRM <531..>632 CDD:331975 26/142 (18%)
Myb_DNA-binding 597..640 CDD:306708 14/100 (14%)
Paf1 <640..728 CDD:309201 29/197 (15%)
DUF4045 <1304..>1485 CDD:330572 60/262 (23%)
Herpes_BLLF1 <2014..2358 CDD:330317 87/466 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1878
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 288 1.000 Inparanoid score I2812
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001675
OrthoInspector 1 1.000 - - otm26268
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13992
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2297
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
88.040

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