DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smr and Ncor2

DIOPT Version :9

Sequence 1:NP_001259491.1 Gene:Smr / 32225 FlyBaseID:FBgn0265523 Length:3607 Species:Drosophila melanogaster
Sequence 2:XP_006249367.1 Gene:Ncor2 / 360801 RGDID:1310293 Length:2569 Species:Rattus norvegicus


Alignment Length:3454 Identity:720/3454 - (20%)
Similarity:1073/3454 - (31%) Gaps:1275/3454 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 GGQQPYKKQ-RLSEANANNMNHLPPH----PQQ---QHQQQQQQQQQHQAHQQQH-QRSSPAQVQ 597
            |..||..:. |.:|.      ..|||    |.|   .|......:.||  |.:.: ...||..:.
  Rat     3 GSTQPVAQTWRAAEP------RYPPHGISYPVQIARPHTDVGLLEYQH--HPRDYTSHLSPGSII 59

  Fly   598 QQQQQQMNSSRQSHNDMCRQVVTTPMGMQLKVETLPQQQQKQQQHQQQQQQQ--QQQGR------ 654
            |.|:::.:                     |..|..|..::.|:.|.:.:.:.  .:.|:      
  Rat    60 QPQRRRPS---------------------LLSEFQPGSERSQELHLRPESRTFLPELGKPDIEFT 103

  Fly   655 --SQPVVSSMSTVVSQPVGTVTVTTAGLSASHSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISP 717
              .:|.:..:...:.:|...                  :|.|..:|:.......:...::|.:||
  Rat   104 ESKRPRLELLPDTLLRPAPL------------------LATGQPSGSEDLTKDRSLAGKLEPVSP 150

  Fly   718 TLP--SDSSIEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKE 780
            ..|  :|..:|......:||:|:..:.:||.||...|..:..|:||::.|.|||  ||.....|.
  Rat   151 PSPPHADPELELTPSRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEA--AKPPEPEKP 213

  Fly   781 LNDNNNDQEPMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQP 845
            ::      .|.:|...||  |.:.||..|||.|:|.|.:|:.......          |||||||
  Rat   214 VS------PPPIESKHRS--LVQIIYDENRKKAEAAHRILEGLGPQVE----------LPLYNQP 260

  Fly   846 LDVEALAMLIRQHQSQIRAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEASAKRKA 910
            .|.......|:.:|: :|..|:|:.::....|....|...::|.:....|:::.||:|.:.:|:|
  Rat   261 SDTRQYHENIKINQA-MRKKLILYFKRRNHARKQWEQRFCQRYDQLMEAWEKKVERIENNPRRRA 324

  Fly   911 REAKNREFFEKVFTELRKQREDKERF-NRVGSR--------IKSEADLEEIMDGLQEQALEDKKM 966
            :|:|.||::||.|.|:|||||.:||. :|||.|        .:||.::.||:|||.||...:|:|
  Rat   325 KESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQM 389

  Fly   967 RSYAVIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKNFGAI 1031
            |..|||||:::||.|:|..:.|.|||::|.:.|::.|:..|||:..|::||:||::|||||||.|
  Rat   390 RQLAVIPPMLYDADQQRIKFINMNGLMDDPMKVYKDRQVTNMWSEQERDTFREKFMQHPKNFGLI 454

  Fly  1032 AASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGVMTRL 1096
            |:.|:||:..:||.||||:||.||||.|:|:|.:|...|:...:.|..|                
  Rat   455 ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQ---------------- 503

  Fly  1097 QREQQQKSGGRSSAVAERERAERAAERERVAEKAAADAAK-----------AAESAAEKASAATK 1150
            |::|||:...|||. .|:|..|:..|.::..||..|:..|           :.|...||.:.|:|
  Rat   504 QQQQQQQQMARSSQ-EEKEEKEKEKEADKEEEKQDAENEKEELSKEKTDDTSGEDNDEKEAVASK 567

  Fly  1151 AVEATAAGEKVAKA-------AAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASS-STASP 1207
                   |.|.|.:       ...:.|..|....|||...||..:|...:.||..|... .||..
  Rat   568 -------GRKTANSQGRRKGRITRSMANEANHEETATPQQSSELASMEMNESSRWTEEEMETAKK 625

  Fly  1208 ATLAGIAADKTDAGKTASASDKNAATAGGPTATGTPTAATTPATATAPPEISAGGE---AKSKNA 1269
            ..|        :.|:..||.   |...|..|.:................||....:   .|.:||
  Rat   626 GLL--------EHGRNWSAI---ARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNA 679

  Fly  1270 EEEAAATAGAATVATAGTP--------ATGASA-----ASAGEATTATG--------ATATAAAK 1313
            ..:...|..||:..||..|        |:||||     |...||:.|:|        .:..||..
  Rat   680 RRKKKKTPAAASEETAFPPAAEDEEMEASGASANEEELAEEAEASQASGNEVPRVGECSGPAAVN 744

  Fly  1314 GVGKPETATEPAGTAAKGADSRPDANDPLAKTASKAINAEGYNAIGGNSSSSSSNATGASAPVQG 1378
            .....|:...|...|.|.|..:|.:.:.|.......:......|...:....:.:|:|..:||  
  Rat   745 NSSDTESVPSPRTEATKDAGPKPASTEALPAATQPPVPPPEEPATVPDEPCPAPDASGPPSPV-- 807

  Fly  1379 VTLNGFKPGYQTVVMANVKASTGGDDSGANAGGAAPGSLAATNASIATSGDKIVKTTPSSRAPNS 1443
                                             |:|.. ||..|::.........|.|      .
  Rat   808 ---------------------------------ASPPP-AAPPAAVDKDEQDQAATVP------Q 832

  Fly  1444 TSSTAANESSSGAGVNTYGHT-ATTAGNYLGQKLKA-------AQVEGLGAGNELHSDVSESKRK 1500
            |......:|.:...|...|.| ...|.....:.:|:       .:.|....|.|....|||:   
  Rat   833 TEDAKEQKSEAEELVIDVGKTEEPEAPEEPPESVKSDHKEETEEEPEDKAKGPEAIETVSEA--- 894

  Fly  1501 RFELNSGEAGGNATSAMTNSSTSGSMNISNSHGLKANAKDGSMMAKTSMASTSSASVVVTSTPSA 1565
              .|...|||..|  |:|..|:||:...|:|                  ::|.||..|.......
  Rat   895 --PLKVEEAGSKA--AVTKGSSSGATQDSDS------------------SATCSADEVDEPEGGD 937

  Fly  1566 SSSSLSSASSMLLISAASVMSTAAGATSSSTATTTATASAISLPLLADGSGNSMVNANEILALDG 1630
            ....||...|:|         |.||...:||                  |....::..::     
  Rat   938 KGRLLSPRPSLL---------TPAGDPRAST------------------SPQKPLDLKQL----- 970

  Fly  1631 KDKLAS---CFVCKAEACPR--TRPLKKGR---------------GQQYGIPDETIPAGARVCNS 1675
            |.:.|:   ..|.|....||  |.|.|...               .||.|    ..|.|      
  Rat   971 KQRAAAIPPIQVTKVHEPPREDTVPPKPAPPVPPPTQHLQPEGDVSQQSG----GSPRG------ 1025

  Fly  1676 CQCKS----------VRSRYPNCP-----LPTCPNPKDRAQRLRNIPSR-LFELAPEVRDPLMAE 1724
             :|:|          ..|.:|..|     |||.| |:..:.....||.| :.:.:|...||....
  Rat  1026 -KCRSPVPPAEKEAEKASFFPAFPAEGPKLPTEP-PRWTSGLPFPIPPREVIKTSPHAADPSAFS 1088

  Fly  1725 FQIPPHATRCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPGGSDTASV 1789
            :..|.|..                .|.|.|                 |......|.|       :
  Rat  1089 YTPPGHPL----------------PLGLHD-----------------SARPVLPRPP-------I 1113

  Fly  1790 ESPENLQRHKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQPQPPPPAPQQQKGSSGRGGDQGT 1854
            .:|..|........|.::|.....||....|.:....:....|..|.              ..|.
  Rat  1114 SNPPPLISSAKHPGVLERQLGTISQQGMSVQLRVPHSEHAKAPMGPL--------------TMGL 1164

  Fly  1855 PLIITPTRMSSKSGSGGAQ-----TAGDNERLLPPAAGQAPKKQKTSEEYDSSATETADEE-NEN 1913
            ||.:.|.:::..||....|     .||      ||.:...|..|:||....::...||... .:.
  Rat  1165 PLAVDPKKLAPFSGVKQEQLSPRGQAG------PPESLGVPTAQETSVLRGTALGSTASGSITKG 1223

  Fly  1914 SPANRQSPKVLFHGH-GHG------HGGHANNVAGLQPP---------------VANMGTGGGV- 1955
            .|:.|.:....:.|. .||      :.|..:.:.|...|               |...|..|.| 
  Rat  1224 LPSTRTADGPSYRGSITHGTPADVLYKGTISRIVGEDSPSRLDRAREDTLPKGHVIYEGKKGHVL 1288

  Fly  1956 -QPGGAA--------GQQVNGPISMRREAVNNVQDCVFSVIERSLKHKGPQPKGGQGQQQGQ--- 2008
             ..||.:        |:..:||                       .|:...||......:|:   
  Rat  1289 SYEGGMSVSQCSKEDGRSSSGP-----------------------PHETAAPKRTYDMMEGRVGR 1330

  Fly  2009 --GQGQGQG-QGQTPGQSQSPSQQQQQQQQQQSANNLERKELTIVREY-RQDPGILKQQQQQQQA 2069
              .....:| .|:...:..||..::|...:......:.|..:....:| |::..:||::      
  Rat  1331 TITSASIEGLMGRAIPEQHSPHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKRE------ 1389

  Fly  2070 GGAPPTSAAGSLPHGTSVQKLTTRPAAVAPPPPAHPLTPTSTGCAGSNNGTSDSLATLSVVNSHM 2134
             |.||                        ||||...||.|      ......|.|..|.:..:|.
  Rat  1390 -GTPP------------------------PPPPPRDLTET------YKTRPLDPLGPLKLKPTHE 1423

  Fly  2135 GMVGIGHPGPMAHASSAGGIGVDKATITPVVKSSSGSSKSGGGSASSHSTATPPETIIYNVPVAH 2199
            |:|                     ||:           |..|.|             |:.:|...
  Rat  1424 GVV---------------------ATV-----------KEAGRS-------------IHEIPREE 1443

  Fly  2200 PQR--GIP----PPSQHSVHPAHPSHTQHPAHPQHSSHGQHTQLQVPEPEPQTLDLSIKKPPRDG 2258
            .:|  .:|    |..:.|:...:..::..||..:            |.|.||...|..       
  Rat  1444 LRRTPELPLAPRPLKEGSITQTYRENSIWPATYR------------PGPSPQGTPLKY------- 1489

  Fly  2259 HSPHTGAGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHIVRSGGMYRGDTVTVPSLAAPSSYLYP 2323
                           .||.|||.           |.||.|||                       
  Rat  1490 ---------------DSGVPSSG-----------SKKHDVRS----------------------- 1505

  Fly  2324 TRSVKTIGGGGVVPGVLPGVPGSALYLQPVPVPVPISISGQGQ----------LPPRAGQPPPAQ 2378
                            :.|.||     :|.|...|:.|....:          |..|:|....|.
  Rat  1506 ----------------IIGSPG-----RPFPALHPLDIMADARALERACYEESLKSRSGTSSGAG 1549

  Fly  2379 PPSGRGVAKVPPKL-SPQQAHHLHPSHG-----H----SPSQQQQQQQQQQQQQQQQAAAAQQQL 2433
            ....||...|.|:| .|:|:...:..||     |    ||...::...:.|:.....:.|:|.:.
  Rat  1550 GSITRGAPVVVPELGKPRQSPLAYEDHGAPFTSHLPRGSPVTTREPTPRLQEGSLLSSKASQDRK 1614

  Fly  2434 LVKSGSITHGTP---ANSAQQQIIVHAPATAAAAPSSLLSPKFDGLVRQTTPEGVGSVGPGGASG 2495
            |.       .||   |.|....:..|.|..        :|| ::.|:|..|  ||          
  Rat  1615 LT-------STPREIAKSPHSTVPEHHPHP--------ISP-YEHLLRGVT--GV---------- 1651

  Fly  2496 SGKHGSITQG-TPLHMPPHHLESKRPYE----SYYKSSQRHSPAQQPGGNQQLPPPPQQSSPQAP 2555
                 .:.:| .||...|..:....|.|    :||  ..||           |.|.|  :.|...
  Rat  1652 -----DLYRGHIPLAFDPTSIPRGIPLEAAAAAYY--LPRH-----------LAPSP--TYPHLY 1696

  Fly  2556 PP---QGYGVGVSSPYARSPFAGVVEQPQVLSTRQIVMHDYITSQQMQGQQQQQQQQQQQQRNMS 2617
            ||   :||                 .....|..||.:::||||||||   .........|:.:|.
  Rat  1697 PPYLIRGY-----------------PDTAALENRQTIINDYITSQQM---HHNAASAMAQRADML 1741

  Fly  2618 RGSS----------ASG---------------------GGGGGGSDK-----ESPSPRNSVGSAS 2646
            ||.|          |:|                     |......|:     .:|.|.:|..|:|
  Rat  1742 RGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAIDRLAYLPTAPPPFSSRHSSS 1806

  Fly  2647 GFAYGG-----------------------DK---------ESAPRGRP--EYSSRAS----PADH 2673
            ..:.||                       ||         |.||..||  |.||.|.    ||.|
  Rat  1807 PLSPGGPTHLAKPTATSSSERERERERERDKSILTSTTTVEHAPIWRPGTEQSSGAGGSSRPASH 1871

  Fly  2674 VNSTPSPHRTPPPQRQGVIQR-----HNTGSK-------PPSP-----------AAPPPSRMHMP 2715
            .:.    |....|:.|..:|:     |||..|       |.:|           ::|.......|
  Rat  1872 THQ----HSPISPRTQDALQQRPSVLHNTSMKGVVTSVEPGTPTVLRWARSTSTSSPVRPAATFP 1932

  Fly  2716 PYQYAPSGHDALASFVDVAVQQPQLPVPSQKDDKSPGPSTAPGQVPGSGPPLGPSPLPPHAVVGV 2780
            |..:.|.| ..|.......::...||..:.:..:...|....|....:.||              
  Rat  1933 PATHCPLG-GTLEGVYPTLMEPVLLPKETSRVTRPERPRVDAGHAFLTKPP-------------- 1982

  Fly  2781 AQPPPPTAHHDQRYRDLTLHHHHHTLVQQQIAQQ--QHYRSLNVAAQV---DMQRQMDQAKRVMR 2840
            |:.|..:.......|.|......||.:.:..|:.  .|:.|.::.|..   |:.|:..|:|    
  Rat  1983 AREPASSPSKSSEPRSLAPPSSSHTAIARTPAKSLAPHHASPDLPAPTSASDLHREKTQSK---- 2043

  Fly  2841 HQQHQVQQQQQQQQQQQHNHALERDREMQERMRERDREREREREREQRERERERERERERERERR 2905
                                                                             
  Rat  2044 ----------------------------------------------------------------- 2043

  Fly  2906 EQDRARRVVAEEREHDSRRMERMFAGNVVTGSGGAGGGGPSPGQFLRASVPETGPPRSIPDRERE 2970
                                                                   |.||.:.|..
  Rat  2044 -------------------------------------------------------PFSIQELELR 2053

  Fly  2971 SYYRQAHGGPAPEDTPGQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSG 3035
            |..:..            |:|.:.|||||..:|........|.......|            |.|
  Rat  2054 SLGKTT------------LTAATFIDAIITRQIAHERGPREGGSLAIDSP------------GDG 2094

  Fly  3036 GGTGTRSSPANVLHPMYLRDLRQPLDGGAGSMLTAENNGKPSSSGSPSVINIDLDQERISAAAAA 3100
            ..:|...||..|          :|:                |...|||:.:              
  Rat  2095 YHSGAGYSPDGV----------EPI----------------SPVSSPSLTH-------------- 2119

  Fly  3101 VAQQQQQQQAPPPSQSSQSRSVHGQLRTPTSQAGGSAPSPQQIHTKSITFGELTDSIITSDYGTN 3165
                  .:....|.:..:...:.|:||       ...|.|.::.      ||....         
  Rat  2120 ------DKGLSKPLEELEKSHLEGELR-------HKQPGPMKLS------GEAAHL--------- 2156

  Fly  3166 PHLRPPYMAYLQETQSILPPDRWKQNRRMQQKAEEAKHHSQQQQQQQHQQQHHAQQQQQQQQQHH 3230
            |||||     |.|:|....|        :.|.|...|.|    |:.....||.::...|...:||
  Rat  2157 PHLRP-----LPESQPSSSP--------LLQTAPGIKGH----QRVVTLAQHISEVITQDYTRHH 2204

  Fly  3231 AQQHHPQMPGTGSGSAPGGAGQGGGSGGPGSGGGGAGRASTPGEDGRNIIRMPQAVSPRKFNHEM 3295
            .||....:|.. ..|.||                    ||.|..|    :|.|.:          
  Rat  2205 PQQLSGPLPAP-LYSFPG--------------------ASCPVLD----LRRPPS---------- 2234

  Fly  3296 MLHHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGGGGAPGAGGPGSGGGATTIEKYVKTRIAEV 3360
                            ..:||     |...|||:       .|.|.|.||..:.|          
  Rat  2235 ----------------DLYLP-----PPDHGTPA-------RGSPHSEGGKRSPE---------- 2261

  Fly  3361 MRDDIGYGKNRTVEVRTEDEVTADMVAHSHAAVHAAHVAHAAHVAHAAAMELQHRSKEPPPPEIS 3425
                    .::||...:||.:  :.|:.........|       |.:.|..|.:|..|...|.  
  Rat  2262 --------PSKTVLSSSEDAI--EPVSPPEGMTEPGH-------ARSTAYPLLYRDGEQGEPR-- 2307

  Fly  3426 VSRKTPNQYEVVDASGRRSAGSGSVSV-----SVSGANSHHSPYHPPAAAYAPSTYAFPYSALNV 3485
            :..|:|.......|...:...|.|..|     .::...:.|:...|......|.|..|     |:
  Rat  2308 MGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNIGQPGTEIF-----NM 2367

  Fly  3486 PGAAG-------------------GL------------------PP-----HQPLQLAHQ--AVA 3506
            |...|                   ||                  ||     ..||..:..  |.|
  Rat  2368 PAITGAGLMTCRSQAVQEHASTNMGLEAIIRKALMGKYDQWEEPPPLGANAFNPLNASASLPAAA 2432

  Fly  3507 PPGAFAKAKAAHALSELGAVGGGVSLVVGGGSGGIAGGPG-GVSVGVGVPGGGG----------- 3559
            .|...|..::.|.|:..|  |||.:.|.|..|...|..|. |::.|...|....           
  Rat  2433 MPITTADGRSDHPLTSPG--GGGKAKVSGRPSSRKAKSPAPGLAPGDRPPSVSSVHSEGDCNRRT 2495

  Fly  3560 ----------PGSGGGGGGGHNSSSSQASAAVAAA-----VAAAA-----------SESKPLLLS 3598
                      |.|.|.....:|....:..|.|.|:     :||.:           .|.||||.|
  Rat  2496 PLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLAAGSGPLAGPHHAWDEEPKPLLCS 2560

  Fly  3599 KYDALSDED 3607
            :|:.|||.:
  Rat  2561 QYETLSDSE 2569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmrNP_001259491.1 GPS2_interact 710..798 CDD:292412 26/89 (29%)
TPH <725..1006 CDD:290579 102/289 (35%)
SANT 1009..1048 CDD:238096 21/38 (55%)
Ncor2XP_006249367.1 GPS2_interact 141..229 CDD:406267 29/97 (30%)
SbcC <156..>411 CDD:223496 96/275 (35%)
SANT 432..475 CDD:419695 24/42 (57%)
RSC8 <539..>649 CDD:227584 29/127 (23%)
Myb_DNA-binding 614..657 CDD:395191 10/53 (19%)
PHA03247 <1775..2032 CDD:223021 55/275 (20%)
PHA03247 <1917..2321 CDD:223021 117/743 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1878
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 330 1.000 Inparanoid score I2371
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001675
OrthoInspector 1 1.000 - - oto96756
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13992
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
77.050

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