|
Fly 542 GGQQPYKKQ-RLSEANANNMNHLPPH----PQQ---QHQQQQQQQQQHQAHQQQH-QRSSPAQVQ 597
|..||..:. |.:|. ..||| |.| .|......:.|| |.:.: ...||..:.
Mouse 3 GSTQPVAQTWRAAEP------RYPPHGISYPVQIARSHTDVGLLEYQH--HPRDYTSHLSPGSII 59
Fly 598 QQQQQQMNSSRQSHNDMCRQVVTTPMGMQLKVETLPQQQQKQQQHQQQQQQQ--QQQGR------ 654
|.|:::.: |..|..|..::.|:.|.:.:.:. .:.|:
Mouse 60 QPQRRRPS---------------------LLSEFQPGSERSQELHLRPESRTFLPELGKPDIEFT 103
Fly 655 --SQPVVSSMSTVVSQPVGTVTVTTAGLSASHSGSSGNVAAGLGTGNTGSASTEAYHPQVEAISP 717
.:|.:..:...:.:| |..:|.|..:|:.......:...::|.:||
Mouse 104 ESKRPRLELLPDTLLRP------------------SPLLATGQPSGSEDLTKDRSLAGKLEPVSP 150
Fly 718 TLP--SDSSIEERGRTSAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKE 780
..| :|..:|......:||:|:..:.:||.||...|..:..|:||::.|.||| ||.....|.
Mouse 151 PSPPHADPELELAPSRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEA--AKPPEPEKP 213
Fly 781 LNDNNNDQEPMVELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQP 845
:: .|.:|...|| |.:.||..|||.|:|.|.:|:....... |||||||
Mouse 214 VS------PPPIESKHRS--LVQIIYDENRKKAEAAHRILEGLGPQVE----------LPLYNQP 260
Fly 846 LDVEALAMLIRQHQSQIRAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEASAKRKA 910
.|.......|:.:|: :|..|:|:.::....|....|...::|.:....|:::.||:|.:.:|:|
Mouse 261 SDTRQYHENIKINQA-MRKKLILYFKRRNHARKQWEQRFCQRYDQLMEAWEKKVERIENNPRRRA 324
Fly 911 REAKNREFFEKVFTELRKQREDKERF-NRVGSR--------IKSEADLEEIMDGLQEQALEDKKM 966
:|:|.||::||.|.|:|||||.:||. :|||.| .:||.::.||:|||.||...:|:|
Mouse 325 KESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQM 389
Fly 967 RSYAVIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKNFGAI 1031
|..|||||:::||.|:|..:.|.|||::|.:.|::.|:..|||:..|::||:||::|||||||.|
Mouse 390 RQLAVIPPMLYDADQQRIKFINMNGLMDDPMKVYKDRQVTNMWSEQERDTFREKFMQHPKNFGLI 454
Fly 1032 AASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGVMTRL 1096
|:.|:||:..:||.||||:||.||||.|:| ||.|...|:|..|.|
Mouse 455 ASFLERKTVAECVLYYYLTKKNENYKSLVR------RSYRRRGKSQQQQQQ-------------- 499
Fly 1097 QREQQQKSGGRSSAVAERERAERAAERERVAEKAAADAAK-----------AAESAAEKASAATK 1150
|::|||:...|||. .|:|..|:..|.::..||..|:..| :.|...||.:.|:|
Mouse 500 QQQQQQQQMARSSQ-EEKEEKEKEKEADKEEEKQDAENEKEELSKEKTDDTSGEDNDEKEAVASK 563
Fly 1151 AVEATAAGEKVAKA-------AAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASS-STASP 1207
|.|.|.: ...:.|..|....|||...||..:|...:.||..|... .||..
Mouse 564 -------GRKTANSQGRRKGRITRSMANEANHEETATPQQSSELASMEMNESSRWTEEEMETAKK 621
Fly 1208 ATL------AGIAADKTDAGKTASAS-----------------DKNAATAGGPTATGTPTAATTP 1249
..| :.|| :....||.|.. .::.....|| |....|:..
Mouse 622 GLLEHGRNWSAIA--RMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMPGP---GLRHRASPA 681
Fly 1250 ATATAPPEISAGGEAKSKNAEEEAAATAGAATVATAGTP--------ATGASA-----ASAGEAT 1301
.|||.. .:.|.:||..:...|..||:..||..| |:|||| |...||:
Mouse 682 VTATVL------SQEKERNARRKKKKTPAAASEETAFPPAAEDEEMEASGASANEEELAEEAEAS 740
Fly 1302 TATG--------ATATAAAKGVGKPETATEPAGTAAKGADSRPDANDPLAKTASKAINAEGYNAI 1358
.|:| .:..||.......|:...|...|.|....:| |.::|:.|
Mouse 741 QASGNEVPRVGECSGPAAVNNSSDTESVPSPRSEATKDTGPKP--------TGTEALPA------ 791
Fly 1359 GGNSSSSSSNATGASAPVQGVTLNGFKPGYQTVVMANVKASTGGDDSGANAGGAAPGSLAATNAS 1423
....|| |..:...:|..:.|...|.||..:...:| |.||..|:
Mouse 792 ------------ATQPPV---------PPPEEPAVAPAEPSPVPDASGPPSPEPSP-SPAAPPAT 834
Fly 1424 IATSGDKIVKTTPSSRAPNSTSSTAANESSSGAGVNTYGHTATTAGNYLGQKLKAAQVEGLGAGN 1488
: ||..:..|::.||.:..: |.:.::.|.:..|.
Mouse 835 V----DKDEQEAPAAPAPQTEDA----------------------------KEQKSEAEEIDVGK 867
Fly 1489 ELHSDVSESKRKRFELNSGEAGGNATSAMTNSSTSGSMNISNSHGLKANAKDGSMMAKTSMASTS 1553
....:.||.. ...:|::.|:.:.......|..:
Mouse 868 PEEPEASEEP--------------------------------PESVKSDHKEETEEEPEDKAKGT 900
Fly 1554 SASVVVTSTPSASSSSLSSASSMLLISAASVMSTAAGATSSSTATTTATASAISLPLLADGSGNS 1618
.|...|:..| ..:..|.| .||....:::|||..|.::.|.:|..:..|
Mouse 901 EAIETVSEAP----LKVEEAGS----KAAVTKGSSSGATQDSDSSATCSADEVDEP--------- 948
Fly 1619 MVNANEILALDGKDK--LASCFVCKAEACPRTRPLKKGRGQQYGIPDETIPAG-ARVCNSCQCKS 1680
:|.|| |.| || |....||| .|...|
Mouse 949 ----------EGGDKGRLLS---------PR--------------PSLLTPAGDPRASTS----- 975
Fly 1681 VRSRYPNCPLPTCPNPKDRAQRLRNIPSRLFELAPEVRDPLMAEFQIPPHATRCCSACLMRIRRK 1745
|..|| :.|...||...|| |...|:.
Mouse 976 -----PQKPL----DLKQLKQRAAAIP--------------------PIQVTKV----------- 1000
Fly 1746 LDPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPGGSDTASVESPENLQRHKSLTMVKQQQQQ 1810
.||...||.
Mouse 1001 ---------------------------------HEPPREDTV----------------------- 1009
Fly 1811 QQQQQQQQQQQQQQQQQQLSQPQPPPPAP------------QQQKGSSGRGGDQGTPLIITPTRM 1863
.|:|.||.| .||.|.|.||
Mouse 1010 --------------------PPKPVPPVPPPTQHLQPEGDVSQQSGGSPRG-------------- 1040
Fly 1864 SSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSEEYDS---------SATETADEENENSPANRQ 1919
.|:|....|:...:.....|....:.||.......:.| ...:|:....:.|..:..
Mouse 1041 KSRSPVPPAEKEAEKPAFFPAFPTEGPKLPTEPPRWSSGLPFPIPPREVIKTSPHAADPSAFSYT 1105
Fly 1920 SPKVLFHGHGHGHGGHANNVAGL-QPPVANMG--TGGGVQPGGAAGQQVNGPISMRREAVNNVQD 1981
.| ||....|.|.:....| :||::|.. ......||
Mouse 1106 PP-----GHPLPLGLHDSARPVLPRPPISNPPPLISSAKHPG----------------------- 1142
Fly 1982 CVFSVIERSLKHKGPQPKGGQGQQQGQGQGQGQGQGQTPGQSQSPSQQQQQQQQQQSANNLERKE 2046
|:||.| |...|||... |.:.|..:..:... ..
Mouse 1143 ----VLERQL---------GAISQQGMSV-----------QLRVPHSEHAKAPM---------GP 1174
Fly 2047 LTIVREYRQDPGIL------KQQQQQQQAGGAPPTSAAGSLPHGTSVQKLTTRPAAVAPPPPAHP 2105
||:......||..| ||:|...:....||.|........|||
Mouse 1175 LTMGLPLAVDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQETSV------------------ 1221
Fly 2106 LTPTSTGCAGSNNGTSDSLATLSVVN-SHMGMVGIGHPGPMAHASSAGGIGVDKATITPVVKSSS 2169
|..|:.|.|.|.:.|....:|.:... |:.|.:..|.|..:.: |.||:.:|
Mouse 1222 LRGTALGSATSGSITKGLPSTRAADGPSYRGSITHGTPADVLY----------KGTISRIV---- 1272
Fly 2170 GSSKSGGGSASSHSTATPPETIIYNVPVAHPQRGIPPPSQHSVHPAHPSHTQHPAHPQHSSHGQH 2234
|..:.|.......:|: |..|.::..
Mouse 1273 ------GEDSPSRLDRAREDTL---------------PKGHVIYEG------------------- 1297
Fly 2235 TQLQVPEPEPQTLDLSIKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHIVR 2299
:.||......|.|.|..|...|.||| |||..|.:.| |
Mouse 1298 ---------------------KKGHVLSYEGGMSVSQCSKEDGRSSS----GPPHETAAPK---R 1334
Fly 2300 SGGMYR---GDTVTVPSL------AAPSSYLYPTRSVKTIGGGGVVPGVLPGVPGSAL-----YL 2350
:..|.. |.|||..|: |.|..:....:....|.| .:..|:|.|.: ||
Mouse 1335 TYDMMEGRVGRTVTSASIEGLMGRAIPEQHSPHLKEQHHIRG-----SITQGIPRSYVEAQEDYL 1394
Fly 2351 QPVPVPVPISISGQGQLPPRAGQPPPAQPPSGRGVAKVPPKLSPQQAHHLHPSHG------HSPS 2409
: .:.:|..|.|.|||..||........|..|.|.....|.|:|. ....
Mouse 1395 R-----------REAKLLKREGTPPPPPPPRDLTETYKPRPLDPLGPLKLKPTHEGVVATVKEAG 1448
Fly 2410 QQQQQQQQQQQQQQQQAAAAQQQLLVKSGSITHGTPANSAQQQIIVHAPAT------------AA 2462
:...:..:::.::..:...|.:.| |.||||.|||..... .||:| :.
Mouse 1449 RSIHEIPREELRRTPELPLAPRPL--KEGSITQGTPLKYDS-----GAPSTGTKKHDVRSIIGSP 1506
Fly 2463 AAPSSLLSPKFD------GLVRQTTPEGVGSVGPGGASGSGKHGSITQGTPLHMP----PHHLES 2517
..|...|.| .| .|.|....|.:.| ..|.:||:| ||||:|.|:.:| |. :|
Mouse 1507 GRPFPALHP-LDIMADARALERACYEESLKS-RSGTSSGAG--GSITRGAPVVVPELGKPR--QS 1565
Fly 2518 KRPYESYYKSSQRHSPAQQPGGNQQLPPPPQQSSPQAPPPQGYGVGVSSP--YARSPFAGVVE-Q 2579
...||.:......|.|...|...::..|..|:.|..:..........|:| .|:||.:.|.| .
Mouse 1566 PLTYEDHGAPFTSHLPRGSPVTTREPTPRLQEGSLLSSKASQDRKLTSTPREIAKSPHSTVPEHH 1630
Fly 2580 PQVLSTRQIVMHDYITSQQMQGQQQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESPSPRNSVGS 2644
|..:|..: ::.||.: |.|
Mouse 1631 PHPISPYE---------------------------HLLRGVT--------GVD------------ 1648
Fly 2645 ASGFAYGG------DKESAPRGRPEYSSRAS---PADHVNSTPS-PHRTPP------------PQ 2687
.|.| |..|.|||.|..::.|: |. |:..:|: ||..|| ..
Mouse 1649 ----LYRGHIPLAFDPTSIPRGIPLEAAAAAYYLPR-HLAPSPTYPHLYPPYLIRGYPDTAALEN 1708
Fly 2688 RQGVI--------QRHNTGSKPPSPA------APPPSRMHMPPYQYAPSGHDALASFVDVAVQQP 2738
||.:| ..||..|.....| :|..|.:.: .|...|.| .:|:: |.|
Mouse 1709 RQTIINDYITSQQMHHNAASAMAQRADMLRGLSPRESSLAL-NYAAGPRG------IIDLS-QVP 1765
Fly 2739 QLP--VPSQKDDKSPG-PSTAPGQ---VPGSGPPL----GPSPLPPHAVVGVAQPPPPTAHHDQR 2793
.|| || .:|| |:||..: :|.:.||. ..|||.|.....:|:|...::
Mouse 1766 HLPVLVP-----PTPGTPATAIDRLAYLPTAPPPFSSRHSSSPLSPGGPTHLAKPTATSS----- 1820
Fly 2794 YRDLTLHHHHHTLVQQQIAQQQHYRSLNVAAQVDMQRQMDQAKRVMRHQQHQVQQQQQQQQQQQH 2858
Mouse 1821 ----------------------------------------------------------------- 1820
Fly 2859 NHALERDREMQERMRERDREREREREREQRERERERERERERE--------------RERREQDR 2909
.||||||||||::. |...||
Mouse 1821 -----------------------------SERERERERERDKSILTSTTTVEHAPIWRPGTEQ-- 1854
Fly 2910 ARRVVAEEREHDSRRMERMFAGNVVTGSGGAGGGGPSPGQFLRASVPETGPPRSIPDRERESYYR 2974
|.||||.. .|........|.:...:....:.....:.
Mouse 1855 ---------------------------SSGAGGSS-RPASHTHQHSPISPRTQDALQQRPSVLHN 1891
Fly 2975 QAHGGPAPEDTPGQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSGGGTG 3039
.:..|......|| ...:::...:.|..:...|...|| |: .|.|| |||.
Mouse 1892 TSMKGVVTSVEPG-------TPTVLRWARSTSTSSPVRPAATFP-PA-THCPL--------GGTL 1939
Fly 3040 TRSSPANVLHPMYL--------RDLRQPLDGGAGSMLTAENNGKPSSSGSPSVINIDLDQERI-- 3094
....| .::.|:.| |..|..:|.| .:.||.....:|:||.|.| .:.|.
Mouse 1940 EGVYP-TLMEPVLLPKETSRVARPERPRVDAG-HAFLTKPPAREPASSPSKS------SEPRSLA 1996
Fly 3095 --SAAAAAVAQQQQQQQAP------PPSQSSQS-------------------RSVHGQLRTPTS- 3131
|::..|:|:...:..|| ||:.:|.| ||:.....|..:
Mouse 1997 PPSSSHTAIARTPAKNLAPHHASPDPPAPTSASDLHREKTQSKPFSIQELELRSLGKTTLTAATF 2061
Fly 3132 ---------------QAGGS--------------------------APSPQQIHTKSIT------ 3149
:.||| ..||...|.|.::
Mouse 2062 IDAIITRQIAHERGPREGGSLANDSPGDGYHSGAGYSPDGVEPISPVSSPSLTHDKGLSKPLEEL 2126
Fly 3150 -----FGELTDS-----IITSDYGTNPHLRPPYMAYLQETQSILPPDRWKQNRRMQQKAEEAKHH 3204
.|||... .::::....||||| |.|:|....| :.|.|...|.|
Mouse 2127 EKSHLEGELRHKQPGPMKLSAEAAHLPHLRP-----LPESQPSSSP--------LLQTAPGIKGH 2178
Fly 3205 SQQQQQQQHQQQHHAQQQQQQQQQHHAQQHHPQMPGTGSGSAPGGAGQGGGSGGPGSGGGGAGRA 3269
|:.....||.::...|...:||.||....:|.. ..|.|| |
Mouse 2179 ----QRVVTLAQHISEVITQDYTRHHPQQLSGPLPAP-LYSFPG--------------------A 2218
Fly 3270 STPGEDGRNIIRMPQAVSPRKFNHEMMLHHVMGTTGAGGEAGQFFLPSRVVLPEQRGTPSGGGGA 3334
|.|..| :|.|.: ..:|| |...|||:
Mouse 2219 SCPVLD----LRRPPS--------------------------DLYLP-----PPDHGTPA----- 2243
Fly 3335 PGAGGPGSGGGATTIEKYVKTRIAEVMRDDIGYGKNRTVEVRTEDEVTADMVAHSHAAVHAAHVA 3399
.|.|.|.||..:.|. .||.: :| .:||.: :.|:.........|
Mouse 2244 --RGSPHSEGGKRSPEP-SKTSV-------LG---------SSEDAI--EPVSPPEGMTEPGH-- 2285
Fly 3400 HAAHVAHAAAMELQHRSKEPPPPEISVSRKTPNQYEVVDASGRRSAGSGSVSV-----SVSGANS 3459
|.:.|..|.:|..|...|. :..|:|.......|...:...|.|..| .::...:
Mouse 2286 -----ARSTAYPLLYRDGEQGEPR--MGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLN 2343
Fly 3460 HHSPYHPPAAAYAPSTYAFPYSALNVPGAAG-------------------GL------------- 3492
.|:...|......|.|..| |:|...| ||
Mouse 2344 THNRNEPEYNIGQPGTEIF-----NMPAITGAGLMTCRSQAVQEHASTNMGLEAIIRKALMGKYD 2403
Fly 3493 -----PP-----HQPLQLAHQ--AVAPPGAFAKAKAAHALSELGAVGGGVSLVVGGGSG------ 3539
|| ..||..:.. |.|.|...|..::.|||:..| |||.:.|.|..|.
Mouse 2404 QWEEPPPLGANAFNPLNASASLPAAAMPITTADGRSDHALTSPG--GGGKAKVSGRPSSRKAKSP 2466
Fly 3540 --GIAGG--PGGVSVGVGVPGGGG---------------PGSGGGGGGGHNSSSSQASAAVAAA- 3584
|:|.| |..|| .|...|. |.|.|.....:|....:..|.|.|:
Mouse 2467 APGLASGDRPPSVS---SVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASP 2528
Fly 3585 ----VAAAA-----------SESKPLLLSKYDALSDED 3607
:||.: .|.||||.|:|:.|||.:
Mouse 2529 PPPGLAAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE 2566
| 
