DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smr and Ncor1

DIOPT Version :9

Sequence 1:NP_001259491.1 Gene:Smr / 32225 FlyBaseID:FBgn0265523 Length:3607 Species:Drosophila melanogaster
Sequence 2:XP_017169845.1 Gene:Ncor1 / 20185 MGIID:1349717 Length:2529 Species:Mus musculus


Alignment Length:3346 Identity:703/3346 - (21%)
Similarity:1064/3346 - (31%) Gaps:1261/3346 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   577 QQQQHQAHQQQHQRSSPAQVQQQQQQQMNSSRQSHNDMCRQVVTTPMGMQLKVETLPQQQQKQQQ 641
            :|.::.:|..|:...|   .:.||:..:...|.||.::                      .:..|
Mouse    16 EQSRYPSHSVQYTFPS---TRHQQEFAVPDYRSSHIEV----------------------SQASQ 55

  Fly   642 HQQQQQQQQQQGRSQPVVSSMSTVVSQPVGTVTVTTAGLSASHSGSSGNVAAGLGTGNTGSASTE 706
            ..||||||||..|...::|.......:|....|    |....|||.|          .....|.|
Mouse    56 LLQQQQQQQQLRRRPSLLSEFHPGSDRPQERRT----GYEQFHSGPS----------PVDHDSLE 106

  Fly   707 AYHPQVEAIS---------PTLPSDSSIEERGRTSA----------------------------- 733
            :..|::|.:|         ..||...|:.|..|:||                             
Mouse   107 SKRPRLEPVSDAHFQRVSAAVLPLVHSLPEGLRSSADAKKDSAFGSKHEAPSSPLAGQPCGDDQN 171

  Fly   734 -------KEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKELNDNNNDQEPM 791
                   ||:|:..:.:||.||...|..:..|:||::.|.|||  ||.....|.::      .|.
Mouse   172 ASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEA--AKPPEPEKPVS------PPP 228

  Fly   792 VELSWRSQMLAEKIYAANRKTAQAQHSMLQNAAADESSPGSVAGRPWLPLYNQPLDVEALAMLI- 855
            ||...||  :.:.||..|||.|:..|.:.:          .:..:..|||||||.|.:.....| 
Mouse   229 VEQKHRS--IVQIIYDENRKKAEEAHKIFE----------GLGPKVELPLYNQPSDTKVYHENIK 281

  Fly   856 ------RQHQSQI-RAPLLLHIRKLKAERWAHNQGLVEKYTKDQADWQRRCERMEASAKRKAREA 913
                  |..::|: |..|:|..::....|....|.:.::|.:....|:::.:|:|.:.:|||:|:
Mouse   282 TGVPARRMMKNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKES 346

  Fly   914 KNREFFEKVFTELRKQREDKERFNRVGSR--------IKSEADLEEIMDGLQEQALEDKKMRSYA 970
            |.||::||.|.|:|||||.:|||.|||.|        .:||.::.||:|||.||...:|:||..:
Mouse   347 KTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLS 411

  Fly   971 VIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKALNMWTAGEKETFKEKYLQHPKNFGAIAASL 1035
            ||||:|.||.|||..:.|.|||:||.:.|::.|:.:|:||..|||.||:|::|||||||.||:.|
Mouse   412 VIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYL 476

  Fly  1036 DRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNPAKAQAAQPQCIIDSMTTGVMTRLQREQ 1100
            :|||..|||.||||:||.||||.|:|::..: |..||  :.|.|:|                 .|
Mouse   477 ERKSVPDCVLYYYLTKKNENYKALVRRNYGK-RRGRN--QQQIARP-----------------SQ 521

  Fly  1101 QQKSGGRSSAVAERERAERAAERERVAEKAAADAAKAAESAAEKASAATKAVEATAAGEKVAKAA 1165
            ::|       |.|:|. ::|.:.|:..|:...|..|   ...|.:...||..:.|.|..:..:..
Mouse   522 EEK-------VEEKEE-DKAEKTEKKEEEKKDDEEK---DDKEDSKETTKEKDRTEATAEEPEER 575

  Fly  1166 AAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTASPATLAGIAADKTDAGKTASASDKN 1230
            .........||.:........|.|.:|.|::|:.|:::|..|                       
Mouse   576 EQVTPRGRKTANSQGRRKGRVTRSMTSEAAAANAAAAATEEP----------------------- 617

  Fly  1231 AATAGGPTATGTPTAATTPATATAPPE-ISAGGEAKSKNAEEEAAATAGAATVATAGTPATGASA 1294
                              |.....||| ||......|:..|||       ..||..|....|.:.
Mouse   618 ------------------PPPLPPPPEPISTEPVETSRWTEEE-------MEVAKKGLVEHGRNW 657

  Fly  1295 ASAGEATTATGATATAAAKG--------------VGKPETATEPAGTAAKGADSRPDAN--DPLA 1343
            |:..:   ..|..:.|..|.              :.:.:.....|..|::......|.:  :.:|
Mouse   658 AAIAK---MVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKVSRAVVASRKPREERDVSQCESVA 719

  Fly  1344 KTAS-------KAINAEGYNAIGGNSSSSSSNATGASAPVQGVTLNGFKPGYQTVVMANVKASTG 1401
            .|.|       :|.|.| .|......:.:||:...|.:|                  :.|:|:..
Mouse   720 STVSAQEDEDIEASNEE-ENPEDSEGAENSSDTESAPSP------------------SPVEAAKS 765

  Fly  1402 GDDSGANAGGAAPGSLAATNASIATSGDKIVKTTPSSRAPNSTSSTAANESSSGAGVNTYGHTAT 1466
            .:||..||  |:.|:.... |.:..:.|.....:|||..|  |:..|..||              
Mouse   766 SEDSSENA--ASRGNTEPV-AELEATTDPAPCASPSSAVP--TTKPAERES-------------- 811

  Fly  1467 TAGNYLGQKLKAAQVEGLGAGNELHSDVSESKRKRFELNSGEAGGNATSAMTNSSTSGSMNISNS 1531
                          ||.     ::....|....:..:::..|.|...:|.:...:.:        
Mouse   812 --------------VEA-----QVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPT-------- 849

  Fly  1532 HGLKANAKDGSMMAKTSMASTSSASVVVTSTPSASSSSLSSASSMLLISAASVMSTAAGATSSST 1596
               ||::.|..|....:.||....        .|....|.|.|.                .:.:.
Mouse   850 ---KADSVDPEMQVPENTASKGEG--------DAKERDLESTSE----------------KTEAR 887

  Fly  1597 ATTTATASAISLP-LLADGSGNSMVNANEILALDGKDKLASCFVCKAEACPRTRPLKKGRGQQYG 1660
            ......|..|..| ..:|...::..:|:|  .:||:.:....|...|:                 
Mouse   888 DEDVVVAEQIERPEPQSDDDSSATCSADE--GVDGEPERQRVFPMDAK----------------- 933

  Fly  1661 IPDETIPAGARVCNSCQCKSVRSRYPNCPLPTCPNPKDRAQRLRNIPSRLFELAPEVRDPLMAEF 1725
             |....|.|:.:.:|               |..|||.|       :|......|           
Mouse   934 -PSLLTPPGSILISS---------------PIKPNPLD-------LPQLQHRAA----------- 964

  Fly  1726 QIPPHATRCCSACLMRIRRKLDPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPGGSDTASVE 1790
            .|||..:  |:.|            |:..|             |.||..:.              
Mouse   965 VIPPMVS--CTPC------------NIPIG-------------TPVSGYAL-------------- 988

  Fly  1791 SPENLQRHKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQPQPPPPAPQQQKGSSGRGGDQGTP 1855
                .|||     :|...:....::|:|:|:|...:.:.|                         
Mouse   989 ----YQRH-----IKAMHESALLEEQRQRQEQVDLECRSS------------------------- 1019

  Fly  1856 LIITPTRMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSEEYDSSATETADEENENSPANRQS 1920
                 |...|.|.|...:..|.:...:|.|..:...:|:.  ...|:|..:|      ||. |.|
Mouse  1020 -----TSPCSTSKSPNREWEGKSVAYMPYAEVKRALEQEA--HMHSTAARSA------SPC-RLS 1070

  Fly  1921 PKVLFHGHGHGHGGHANNVAGLQPPV--ANMGTGGGVQPGGAAGQQVNGPISMRREAVNNVQDCV 1983
            |:.:             :.|..||.:  |.......:||   |..||          :.|:.:.|
Mouse  1071 PREV-------------SKAASQPDMSAARYSVPPVLQP---APHQV----------ITNLPEGV 1109

  Fly  1984 FSVIERSLKHKGP------------QPKGGQGQQQGQGQGQGQGQGQTPGQSQSPSQQQQQQQQQ 2036
            .....|..:...|            :|....|....||         |||...|...|...|:  
Mouse  1110 RLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQG---------TPGTYLSSHNQAYPQE-- 1163

  Fly  2037 QSANNLERKELTIVREYRQDPGILKQQQQQQQAGGAPPTSAAGSLPHGTSVQKLTTRPAAVAPPP 2101
                                                .|..:.||:..|...|:.:|:.|      
Mouse  1164 ------------------------------------APKPSVGSISLGLPRQQESTKAA------ 1186

  Fly  2102 PAHPLT--------PTSTGCAGSNNGTSDSLATLSVVNSHMGMVGIGHPGPMAHASSAGGIGVDK 2158
               |||        |.      |.|...:.|.   |...|.|:|. |..|.:...|...|....|
Mouse  1187 ---PLTYIKQEEFSPR------SQNSQPEGLL---VRAQHEGVVR-GTAGAVQEGSITRGTPASK 1238

  Fly  2159 ATITPVVKSSSGSSKSGGGSASSHSTATPPETIIYNVPVAHPQRGIPPPSQHSVHPAHPSHTQHP 2223
            .:: ..:.|..||...|          ||          |.||.|||                  
Mouse  1239 ISV-ETISSLRGSITQG----------TP----------ALPQAGIP------------------ 1264

  Fly  2224 AHPQHSSHGQHTQLQVPEPEPQTLDLSIKKPPRDGHSPHTGAGGS-------SSSGSGSGGPSSS 2281
              .:....|..:::.:.|..|:.:.   ::....||..:.|..|.       .::..|:..|.::
Mouse  1265 --TEALVKGPVSRMPIEESSPEKVR---EEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTA 1324

  Fly  2282 DRHHGPPPPTMSMKHIVRS--GGMYRGDTVTVPSLAAPSSYLYPTRSVKTIGGGGVVPGVLP-GV 2343
            ..        ||:|....:  |.:.:|.::....::||..              |::...|| |.
Mouse  1325 HE--------MSLKRSYEAVEGSIKQGMSMRESPVSAPLE--------------GLICRALPRGS 1367

  Fly  2344 PGSALYLQPVPVPVPISISG---QGQLPPRA-------GQPPPAQ-----PP------------- 2380
            |.|.|..:.|       :||   ||  .|||       |...|.|     ||             
Mouse  1368 PHSDLKERTV-------LSGSIMQG--TPRATAESFEDGLKYPKQIKRESPPIRAFEGAITKGKP 1423

  Fly  2381 ---------SGRGVAKVPPKLSPQQAHHLHPSHGHSPSQQQQQQQQQQQQQQQQAAAAQQQLLVK 2436
                     .||.:.::|                        :|....|:.::.....|....:.
Mouse  1424 YDGITTIKEMGRSIHEIP------------------------RQDILTQESRKTPEVVQSTRPII 1464

  Fly  2437 SGSITHGTPA---NSAQQQIIVHAPATAAAAPSSLLSPKFDGLVRQTTPEGVGSVGPG------- 2491
            .|||:.|||.   |::.|..|.|...:....||.|  |:  |:: :..||.:..|..|       
Mouse  1465 EGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKL--PR--GML-EIVPENIKVVERGKYEDVKA 1524

  Fly  2492 GASGSGKHGSITQGTP------LHMPPHHLESKRPYE---------SYYKSSQRHSP-------- 2533
            |.....:|.|:....|      ||..|....|...|:         ||..:..|.||        
Mouse  1525 GEPVRARHTSVVSSGPSVLRSTLHEAPKAQLSPGLYDDSSARRTPVSYQNTISRGSPMMNRTSDV 1589

  Fly  2534 -AQQPGGNQQ---LPPPPQQSSPQAPPPQGYGVGVS----SPYARSPFAGVV------------- 2577
             :.:...:::   |.|..::|.|...|..|....||    .|:.||..||.|             
Mouse  1590 SSSKSASHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPHHRSSAAGEVYRSHLPTHLDPAM 1654

  Fly  2578 --------------------------EQPQVL---STRQIVMHDYITSQQMQGQQQQQQQQQQQQ 2613
                                      .|.|:.   :|||.:::||||||||             |
Mouse  1655 PFHRALDPAAAAYLLQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQM-------------Q 1706

  Fly  2614 RNMSRGSSASGGGGGGGSDKESPSPRNSVGSASGFAYGGDKESAPRGRPEYSSRASPADHVNSTP 2678
            .|:                                            ||:.:...||.:      
Mouse  1707 VNL--------------------------------------------RPDVTRGLSPRE------ 1721

  Fly  2679 SPHRTPPPQRQGVIQRHNTGSKPPSPAAPPPSRMHMPPYQYAPSGHDALASFVDVAVQQPQLPVP 2743
            .|...|.|..:|:|...|                 |||....|                      
Mouse  1722 QPLGLPYPATRGIIDLTN-----------------MPPTILVP---------------------- 1747

  Fly  2744 SQKDDKSPGPSTAP----GQVPGSGPPLGPSPLPPHAVVGVAQPPPPTAHHDQRYRDLTLHHHHH 2804
                 .:.|.||.|    ..:||:               .|..||.|       |...:|...|.
Mouse  1748 -----HAGGTSTPPMDRITYIPGT---------------QVTFPPRP-------YNAASLSPGHP 1785

  Fly  2805 TLVQQQIAQQQHYRSLNVAAQVDMQRQMDQAKRVMRHQQHQVQQQQQQQQQQQHNHALERDREMQ 2869
            |             .|..||..                                           
Mouse  1786 T-------------HLAAAASA------------------------------------------- 1794

  Fly  2870 ERMRERDREREREREREQRERERERERERER---------ERERREQD----------------R 2909
                ||:||||||:||| |||||||||||||         .|...||.                |
Mouse  1795 ----EREREREREKERE-RERERERERERERIAAAPADLYLRPGSEQPGRPGSHGYVRSPSPSVR 1854

  Fly  2910 ARRVVAEEREHDSRRMERMFAGNVVTGSGGAG-----------------GGGPSPGQFLRASVPE 2957
            .:..:.::|.            :|..|:.|..                 .||||..|.|.||...
Mouse  1855 TQETILQQRP------------SVFQGTNGTSVITPLDPTAQLRIMPLPSGGPSISQGLPASRYN 1907

  Fly  2958 T-------------GPPRSIPDRERESYYRQA------HGGPAPEDTPGQLSAQSLIDAIIKHEI 3003
            |             ..|:....:.:||.:..|      ....|......||..::|  .:.|..:
Mouse  1908 TAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKNL--EVEKRSV 1970

  Fly  3004 NRSNDATAGP-GREFPRPSFVHAPL-----PPRGSGSGGGTGTRS----SPANVLHPMYLRDLRQ 3058
            .....::|.| |:..|..|.|::..     ||..|.......||.    :.||.:..:..|.:..
Mouse  1971 QCVCTSSALPSGKAQPHASVVYSEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIAS 2035

  Fly  3059 PLDGGAGSMLTAENNGKPSSSGSPSVINIDLDQERISAAAAAV---------AQQQQQQQAPPP- 3113
            ..|        |...|..||..|.|     |...|...|:.|:         |..|::.||..| 
Mouse  2036 DKD--------ARERGSQSSDSSSS-----LSSHRYETASDAIEVISPASSPAPPQEKPQAYQPD 2087

  Fly  3114 ------SQSSQSRSVHGQLRTPTSQAGGSAPSPQQ------------------IHTKSITFGELT 3154
                  :::..:|...|.|....||.  .:|||||                  .| :.||..:..
Mouse  2088 MVKANQAENESTRQYEGPLHHYRSQQ--ESPSPQQQPPLPPSSQSEGMGQVPRTH-RLITLADHI 2149

  Fly  3155 DSIITSDYGTNPHLRPPYMAYLQETQSIL--PPDRWKQNRRMQQKAEEAKHHSQQQQQQQHQQQH 3217
            ..|||.|:..|.....|..:..|.:.|.|  .|.|.|.:.|                        
Mouse  2150 CQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVRTKTSSR------------------------ 2190

  Fly  3218 HAQQQQQQQQQHHAQQHHPQMPGTGSGSAPGGAGQGGGSGGPGSGGGGAGRASTPGEDGRNIIRM 3282
            ::.:.|.|...|         |..|...:|...........||.....:...|.|.|.    |..
Mouse  2191 YSPESQSQTVLH---------PRPGPRVSPENLVDKSRGSRPGKSPERSHIPSEPYEP----ISP 2242

  Fly  3283 PQAVSPRKFNHEMMLHHVMGTTGAGGEAGQ------FFLPSRVVLPE--------------QRGT 3327
            ||..:..:....|:|....|...|...:..      .:|||.....|              ::..
Mouse  2243 PQGPAVHEKQDSMLLLSQRGVDPAEQRSDSRSPGSISYLPSFFTKLESTSPMVKSKKQEIFRKLN 2307

  Fly  3328 PSGGGGAP-GAGGPGS---GGGATTIEKYVKTR------------IAEVMRDDIGYGKNRTVEVR 3376
            .||||.:. .|..||:   ...|.|....|.:|            :.:::|        :.:...
Mouse  2308 SSGGGDSDMAAAQPGTEIFNLPAVTTSGAVSSRSHSFADPASNLGLEDIIR--------KALMGS 2364

  Fly  3377 TEDEVTADMVAHSHAAVHAAHVAHAAHVAHAAAMELQHRSKEPPP------PEI---SVSRKTPN 3432
            .:|:|....|..||.   ...:..:|..:...:.|.:....||.|      |::   |.|||:.:
Mouse  2365 FDDKVEDHGVVMSHP---VGIMPGSASTSVVTSSEARRDEGEPSPHAGVCKPKLINKSNSRKSKS 2426

  Fly  3433 QYEVVDASGRRSAGSGSVSVSVSGANSHHSPYHPPAAAYA----PSTYA---FPYSALNV----- 3485
                 ...|:...|:...| |||..:| ...||.....:|    ||:..   |||:.|.:     
Mouse  2427 -----PIPGQSYLGTERPS-SVSSVHS-EGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTIRMLSS 2484

  Fly  3486 ---------PGAAGGLPPHQPLQLAHQAVAP 3507
                     |.|.....|||..::..:..||
Mouse  2485 TPPTQIACAPSAITQAAPHQQNRIWEREPAP 2515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmrNP_001259491.1 GPS2_interact 710..798 CDD:292412 31/132 (23%)
TPH <725..1006 CDD:290579 107/332 (32%)
SANT 1009..1048 CDD:238096 25/38 (66%)
Ncor1XP_017169845.1 GPS2_interact 150..239 CDD:374108 23/98 (23%)
SANT 450..492 CDD:238096 28/41 (68%)
Myb_DNA-binding 637..680 CDD:365977 11/52 (21%)
DUF4775 <691..916 CDD:374284 53/316 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1878
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 389 1.000 Inparanoid score I1984
Isobase 1 0.950 - 0 Normalized mean entropy S7353
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001675
OrthoInspector 1 1.000 - - otm43200
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR13992
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2297
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.030

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