Protein Alignment Smr and gei-8

DIOPT Version :10

• Sequence 1: NP_001259491.1
• Gene: Smr / 32225
• FlyBaseID: FBgn0265523
• Length: 3607
• Species: Drosophila melanogaster
• Sequence 2: NP_498773.3
• Gene: gei-8 / 176145
• WormBaseID: WBGene00001565
• Length: 1778
• Species: Caenorhabditis elegans
• Alignment Length: 2486
• Identity: 437/2486 - (17%)
• Similarity: 709/2486 - (28%)
• Gaps: 1000/2486 - (40%)

  Fly   886 EKYTKDQADWQRRCERMEASAKRKAREAKNREFFEKVFTELRKQREDKERFNRVGSRIKSEADLE 950
            ||:...|.|.|    :.|.:::||.....:|...|..|.||:::|||:||:.| ..||:.|.:..
 Worm    13 EKFKAFQDDLQ----KWEETSERKEYAEFHRVQAESEFPELKREREDRERWAR-AERIRGEDEKS 72

  Fly   951 EIMDGLQEQALEDKKMR-SYAVIPPLMHDARQRRCAYHNENG-LIEDMVAVHQQR--KALNMWTA 1011
            .:   .:|.|  |||:| ..|.||.|:.::.::...:....| :::||...|:|.  ..|..|:.
 Worm    73 ML---AKEHA--DKKIRLGVAKIPRLLTESERKMDEFVERPGSILKDMKKEHRQSVLDRLEEWSP 132

  Fly  1012 GEKETFKEKYLQHPKNFGAIAASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTR-------S 1069
            .|:..||.:...|.|.|..:......|:..|.|.:||::||||:||:..:..::.|:       |
 Worm   133 EERSLFKSRQADHVKIFHGLTEFFVDKTASDLVLFYYMNKKTEDYKKDFKPKKRVTKYKVGAFPS 197

  Fly  1070 SRNPAKAQAAQP-----------QCIIDSMTTGVM----TRLQREQQQ------------KSGGR 1107
            ....|..:...|           .|.....|...:    |.:.:|..:            .||.|
 Worm   198 VEELAYFRMMPPLDFSSFPKNSLMCYFCCRTVNGIDLNGTFMPKEAYEIFAICPDEDRVVCSGCR 262

  Fly  1108 SSAVA--------------ERERAER-------------AAERERVAEKAAADAAKAAESAAEKA 1145
            ..|..              :::||.|             ...|..:.:|..:... |.:......
 Worm   263 EEAAKLYKDNRCFGNRCSNQKKRANRVNRNIPLDFADFPVRTRAFIMDKLGSTRV-AVKFCTPCK 326

  Fly  1146 SAATKAVEATAAGEKVAKAA----AAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTAS 1206
            :|.|:.:......|:...|.    ...........|...|..:||.:....|.|.......:...
 Worm   327 NALTRWINDVNNKEETIMAELLNYEGQVGWTDDEKTKLVTLINSSPTLDWVSISEGMNRRPNECK 391

  Fly  1207 PATLAGIAADKTDAGKT------ASASDKNAATAGGPTATGTPTAATTPATATAPPEISAGGEAK 1265
                  :..|..:..||      ....|.|....||.....|||.::..|..:          ..
 Worm   392 ------MQYDAMNGVKTQPMIEEVDEEDGNGQEEGGDALVNTPTTSSAAARRS----------GL 440

  Fly  1266 SKNAEEEAAATAGAATVATAGTPATGASAASAGEATTATGATATAAAKGVGKP------------ 1318
            ::||::         .|.|...|.:.....:.|         |...|:.|.||
 Worm   441 ARNAKK---------PVRTPRAPRSAGGRRTGG---------AVTRAQAVPKPVEDLGEEIDEME 487

  Fly  1319 -ETATEPAGTAAKGADSRPDANDPLAKTASKAINAEGYNAIGGNSSSSSSN-------------- 1368
             |...|.|...::|.||:.    |..:..|.| :.||.:..|.:..:....
 Worm   488 IEDNDEDASRGSRGKDSKA----PSDRDGSPA-DMEGDSPEGQDQDADQDQDQDQDVDEEEEEVI 547

  Fly  1369 ATGASAPVQ-----GVTLNGFKPGYQTVVMANVKASTGGDDSGANAGGAAPGSLAATNASIATSG 1428
            .....:||:     .:...|.||.:..|
 Worm   548 VRDIDSPVKTLLSPKILSGGHKPDFPPV------------------------------------- 575

  Fly  1429 DKIVKTTPSSR-APNSTSSTAANESSSGAGVNTYGHTATTAGNYLGQKLKAAQVEGLGAGNELHS 1492
            .:|.|.:.||: .|.....|..|||..|...|                            :.|..
 Worm   576 PRIQKPSTSSQPPPPEPMDTKENESDDGEEDN----------------------------DILEI 612

  Fly  1493 DVSESKRKRFELNSGEAGGNATSAMTNSSTSGSMNISNSHGLKANAKDGSMMAKTSMASTSSASV 1557
            ||.|...||....|     :::..:.:||..||.......||....:.....|:      |:|..
 Worm   613 DVDEPPAKRPTPTS-----SSSHLIGSSSVGGSERELGGRGLVQQQQQQQPQAQ------SAAPP 666

  Fly  1558 VVTSTPSASSSSLSSASSMLLISAASVMSTAAG------ATSSSTATTTATASAISLPLLADGSG 1616
            |..||.:|       |::..|::|.|...:.|.      .||:|....|....||..|
 Worm   667 VTVSTAAA-------ATAERLVNATSPSPSVASQHLVPTETSTSVPPVTIVPPAIQQP------- 717

  Fly  1617 NSMVNANEILALDGKDKLASCFVCKAEACPRTRPLKKGRGQQYGIPDETIPAGARVCNSCQCKSV 1681
                    ::.:.|             |.|:..       ||     :|..:.|.:..
 Worm   718 --------VVVISG-------------AAPQFT-------QQ-----QTTHSPALIAQ------- 742

  Fly  1682 RSRYPNCPLPTCPNPKDRAQRLRNIPSRLFELAPEVRDPLMAEFQIPPHATRCCSACLMRIRRKL 1746
                   |:|         |:|  ||.|       |..|...   :.|...|
 Worm   743 -------PIP---------QQL--IPQR-------VSTPAQI---LTPTPVR------------- 766

  Fly  1747 DPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPGGSDTASVESPENLQRHKSLTMVKQQQQQQ 1811
                                 .|..||.|.|:                     .|.:.|||||||
 Worm   767 ---------------------PTAASTPSMDQ---------------------FLGLFKQQQQQQ 789

  Fly  1812 QQQQQQQ------------------QQQQQQQQQQLSQPQPPPPAPQQQKGSSGRGGDQGTPLII 1858
            |||.||.                  ||||||||.|.:|.|     ..|.:||.    ..|||.
 Worm   790 QQQPQQSNLMQQLGNINPQFLALLLQQQQQQQQVQQAQVQ-----AAQTQGSL----TSGTPF-- 843

  Fly  1859 TPTRMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSEEYDSSATETADEENENSPANRQSPKV 1923
                        .||...|          :|.:|..:|.|...:......:..:...|.:|:|.:
 Worm   844 ------------QAQQRPD----------EALQKLFSSPEMLGTLLNAKYQFPQFPQAIQQNPLL 886

  Fly  1924 LFHGHGHGHGGHANNVAGLQPPVANMGTGGGVQPGGAAGQQVNGPISMRREAVNNVQDCVFSVIE 1988
            :          :|.:...||.                  ||:         |:.:.|
 Worm   887 M----------NAQHQLILQQ------------------QQL---------AMQHAQ-------- 906

  Fly  1989 RSLKHKGPQPKGGQGQQQGQGQGQGQGQGQ---TPGQSQSPSQQQQQQQQQQSANNLERKELTIV 2050
                .:..|....|..|..|.|.|.|.:.:   ...|:::.:..|.:.|.||.|:
 Worm   907 ----AQAAQAAQAQAAQAAQAQAQAQAEAKLKTQAAQAKAQADAQARVQTQQQAH---------- 957

  Fly  2051 REYRQDPGILKQQQQQQQAGGAP---PTSAAGSLPHGTSV----QKLTTRPAAVAPPPPAH-PLT 2107
                     ||.|.|.|.....|   |.|.  .:|.|.:.    :.||....:.:..|||| |..
 Worm   958 ---------LKAQAQAQYQMNRPQLIPASV--QMPIGINTAYHQKSLTPSETSASATPPAHRPRA 1011

  Fly  2108 PTSTGC---AGSNNGTSDSLATLSVVNSHMGMVGIGHPGPMAHASSAGGIGVDKATITPVVKSSS 2169
            .|:.|.   ||.:|.....|.||.
 Worm  1012 ATTVGSKMPAGRSNVQEAELRTLK----------------------------------------- 1035

  Fly  2170 GSSKSGGGSASSHSTATPPETIIYNVPV--------AHPQRGIPPPSQHSVHPAHPSHTQHPAHP 2226
                               |.:|..:.:        ||.:|     .:.::       ..:.|..
 Worm  1036 -------------------EELIKRIRLFRDRIAEDAHLKR-----EEENI-------VTYTAQI 1069

  Fly  2227 QHSSHGQHTQL--QVPEPEPQTLDLSIKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPP 2289
            |.|....:|::  |:.:...|.....|:
 Worm  1070 QASRVQYNTEILGQMKQRYEQAAARRIE------------------------------------- 1097

  Fly  2290 PTMSMKHIVRSGGMYRGDTVTVPSLAAPSSYLYPTRSVKTIGGGGVVPGVLPGVPGSALYLQPVP 2354
                                .|..|..|:.:               :.||.......:::
 Worm  1098 --------------------IVKELDEPAKF---------------INGVQNKFNDFSVF----- 1122

  Fly  2355 VPVPISISGQGQLPPRAGQPPPAQPPSGRGVAKVPPKLSPQQAHHLHPSHGHSPSQQQQQQQQQQ 2419
                                                ||.......||.......::|:..|.|||
 Worm  1123 ------------------------------------KLDEIDRQTLHEILQRYAAEQKPDQLQQQ 1151

  Fly  2420 QQQQQQAAAAQQQLLVKSGSITHGTPANSAQQQIIVHAPATAAAAPSSLLSPKFDGLVRQTTPEG 2484
            |..                                                  |..|:||
 Worm  1152 QND--------------------------------------------------FHNLLRQ----- 1161

  Fly  2485 VGSVGPGGASGSGKHGSITQGTPLHMPPHH---LESKRPYESYYKSSQRHSPAQQPGGNQQLPPP 2546
             .::|...|          |...|...||.   ::.::..|::.|..|:|..||:    ::|..|
 Worm  1162 -NNIGIRQA----------QYPALQASPHQAAIIQHQQQQEAFKKLQQQHQDAQK----RKLEAP 1211

  Fly  2547 PQQSSPQAPPPQGYGVGVSSP---YARSPFA------GVVEQPQVLSTRQIVMHDYITSQQMQGQ 2602
            ...::||.   :...:..|||   :::.|..      .||.|.::...|:.::.:...:|.:...
 Worm  1212 VSSATPQV---KRIALSQSSPVQRFSQHPNGTLPHNLAVVYQNKMPQDREKLLQEQQLNQYLFAA 1273

  Fly  2603 QQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESPSPRNSVGSASGFAYGGDKESAPRGRPE---- 2663
            |||..|||||..               |:..|..|.|.|         |.:..::.:|.|.
 Worm  1274 QQQHLQQQQQHH---------------GTQPEQKSKRKS---------GIESITSMQGAPHRHIQ 1314

  Fly  2664 ----YSSRASPADHVNSTPSPHRTPPPQRQGVIQRHNTGSKPPSPAAPPPSRMHMPPYQYAPSGH 2724
                .|||......|:...|..|:..|...|...|..|.                     ..|||
 Worm  1315 LAGPSSSRIQSGRGVSPALSASRSVAPTISGAAGRSITA---------------------GTSGH 1358

  Fly  2725 DALASFVDVAVQQ---------PQL--------------PVPSQKDDK----SPGPSTAPGQVPG 2762
            .:.:.:.....::         |||              |..:...|:    ..||...|..:..
 Worm  1359 SSTSDYNKELAERMNEVFKPTHPQLLQTKASAMNSNAVSPANTNNSDEIECVYQGPPKTPASIKR 1423

  Fly  2763 SGPPLGPSPLPPHAVVGVAQPP--------PPTAHHDQRYRDLTLHHHHHT-------LVQQQIA 2812
            ..|..||..|....:..:...|        ||....|:....|::..:...       :|.:.|:
 Worm  1424 LQPTEGPRTLSGQRMKSILSVPAHQRRSSIPPVKTEDEAMECLSMMMYEEAKAPPSDRIVTKLIS 1488

  Fly  2813 QQQHYRSLNVAAQVD--------MQRQMDQAKRVM---------RHQQHQVQQQQQQQQQQQHNH 2860
            ..:...:.|.:|:..        ::|..::.:|::         |.....:||.||..||..:..
 Worm  1489 SSEAAAAANPSAKFSYLDIFNDVVKRDEERCQRMLQSTSVLQPSRELDAFLQQLQQNPQQYANLS 1553

  Fly  2861 ALERDREMQERMRERDREREREREREQRERERERERERERERER----REQDRARRVVAEEREHD 2921
            |.|:....|.::....::.:::.:.:..::.:::::.|....|:    |......|.:.....|
 Worm  1554 AAEKLALQQYQIHSAHQKSQQQAQLQAAQQLQQQQQARPDHYEKFHLLRPNAEIVRPIPTTFSH- 1617

  Fly  2922 SRRMERMFAGNVVTGSGGAGGGGPSPGQFLRASVPETGPPRSIPDRERESYYRQAHGGPAPEDTP 2986
                   |.....|.:..:....|   |||:       ||.:           .:...|.|..||
 Worm  1618 -------FLNKATTSTVSSSASAP---QFLQ-------PPAA-----------ASIAAPTPISTP 1654

  Fly  2987 GQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSGGGTGTRSS-------- 3043
            ..:.:.|:                 |.....|.|..||.|:.|...|......:..|
 Worm  1655 HAMPSPSV-----------------GVQTAPPTPQAVHHPVMPIIPGKPSSVNSNVSDVSSDDDD 1702

  Fly  3044 -------PANVLHPM--------YLRDLR--------------QPLDGGAGSMLTAENNGKPSSS 3079
                   |||.|.|:        .:.|||              .||      ::.|:|..:|...
 Worm  1703 VRNPEKLPANRLPPLPGDKTAFRSVIDLRATGHVAVTKKIPVKYPL------VVQAQNGIQPIKD 1761

  Fly  3080 GSPSVINI---DLDQE 3092
            ..|...|:   ||..:
 Worm  1762 YGPPCKNLVYEDLSDD 1777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smr	NP_001259491.1	GPS2_interact	708..>776	CDD:464868
		TPH	<725..1020	CDD:464007	42/137 (31%)
		Myb_DNA-binding	1009..1048	CDD:459731	10/38 (26%)
		Atrophin-1	<2187..>2323	CDD:460830	15/145 (10%)
gei-8	NP_498773.3	SANT	356..394	CDD:238096	6/43 (14%)