DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15725 and nacc1b

DIOPT Version :9

Sequence 1:	NP_572823.1	Gene:	CG15725 / 32224	FlyBaseID:	FBgn0030417	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_001922147.3	Gene:	nacc1b / 572093	ZFINID:	ZDB-GENE-121212-1	Length:	591	Species:	Danio rerio

Alignment Length:	741	Identity:	131/741 - (17%)
Similarity:	221/741 - (29%)	Gaps:	263/741 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SSSSSSTPIIRSNAAGIVGAGNVTPSGVSATALVMSSP--PDVILE-------------VGPAPS 59
            |.||..|...|..|.|:..||...    .|..|.|:.|  .:.|||             |.....
Zfish     9 SDSSIETLSSRLQARGLCSAGLYD----MAQMLQMAIPNFGNNILECLNEQRLQGLYCDVSVVVK 69

  Fly    60 NVRFVAHSLVLGMHSGYLRSAIRLDETAAGTAASVSASASISITGATAASCNPSSSSSAASSSSS 124
            ...|.||..||...|.|.|...                             |..|.||......:
Zfish    70 GHTFKAHRAVLAASSSYFRDLF-----------------------------NSGSKSSVVELPPA 105

  Fly   125 AVTTASGELLLYLSNVTADQFAPLLTYMYTGYLDLNVDNIFAVLLATHVLHMPRALEICRSFLAR 189
                           |....|..:|::.|||.|.:|:.:.|.::.....|.:.:.:|....|..:
Zfish   106 ---------------VQPQSFQQILSFCYTGRLSMNLGDQFLLMYTAGFLQIQQIMEKGTEFFLK 155

  Fly   190 AQTEGYLNGNPAAQLCPVPSIPAKIIRPIPSKATMPNFGFLPLPQAPPSVAPSAQPTAHQPTTGI 254
            ..:               ||..::               .|....||||          :|.:.:
Zfish   156 VSS---------------PSCDSQ---------------GLHTEDAPPS----------EPQSPV 180

  Fly   255 APVASASILSSFGTNTQHMEHMEQPIAMLDNEVDEEDVEVFIDSNTVTDNEAEELEPDVDMDCNV 319
            ....:.|| ...|:........:.|:.::              |...|:...:..:| :....:.
Zfish   181 TQTGTGSI-GMGGSTAARPASCQTPLPLV--------------SRVKTEQLPQAPQP-LQEASSY 229

  Fly   320 SVVSSLAA----------SSAGSMNIERLDVKPPTPIPVSVATIISATTTKSQAQSLGQSKGQNS 374
            |||.:..|          ...||.......|:........|...:..    :|.||:....|..:
Zfish   230 SVVCTPVAKRLWEGGNREGGGGSGGSGGGGVRKAARYSQEVVRSVGG----AQPQSIALLGGSGT 290

  Fly   375 RRESNSKGNRTKSSASRSRKSSGLQVAKAPVPAAQLDLTAAATPSITSSKFIIDVASCDGPV--- 436
            ...:::..|...||::....|.|                   |||:.:|         |.|:
Zfish   291 TNSNSNNNNNNNSSSTPEGTSPG-------------------TPSMYTS---------DSPISYH 327

  Fly   437 ---------------RFRRILN--TAYGHKPEAMESNALAGPATAPAGGSSNSTISE--QHRSQQ 482
                           ::|:|.|  |.|               :....|.::|..:..  .|.:.:
Zfish   328 DDDEEEEIPDETTEEQYRQICNMYTMY---------------SMLNVGATANERVESLPDHLTVE 377

  Fly   483 S--VSLSFHQQMARAISSQQRQLSHQQQEESENSGDAIPATIGKQHATGATAASSAMSTSSTH-- 543
            |  ..:...|.:|...:....|:.::...:....||  ||. ..:..||.:...|.....:.|
Zfish   378 SRGRGVRVRQDLASLPTELIAQIGNRCHPKLYEEGD--PAE-KLELVTGTSVFISRAQLMNCHVS 439

  Fly   544 AGS--------------NRKSQATGTGTGSGSAT----ASSAGNQELY-VCVYCKHTFKSQYCYQ 589
            ||:              :|.:.|...|||..|:|    .....::.|: |..||:: |...:
Zfish   440 AGTRHKVLLRRLLAAFFDRSTLANSCGTGIRSSTNDPNRKPLDSRVLHAVKFYCQN-FAPSF--- 500

  Fly   590 KHAKRHLNPLTLTTNDK-----------KLLMESAASMAN----------------------TIE 621
            |.::.:.....:.||.:           ||||..:.:.||                      ::|
Zfish   501 KESEMNAIAADMCTNARRVVRKSWIPKLKLLMAESDAYANFLSDAAKLESDGLGVENAFETGSLE 565

  Fly   622 MDNPSSVGQSGANNSSGSIATGNGAT 647
            ....|..|||.|:...|  .:|:|::
Zfish   566 GGPASESGQSSADALHG--VSGDGSS 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15725	NP_572823.1	BTB	49..189	CDD:197585	28/152 (18%)
		BTB	49..187	CDD:279045	27/150 (18%)
		zf-C2H2	573..595	CDD:278523	5/22 (23%)
nacc1b	XP_001922147.3	BTB	52..154	CDD:279045	25/145 (17%)
		BTB	63..155	CDD:197585	25/135 (19%)
		BEN	445..523	CDD:214981	15/81 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46105
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100