DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15725 and Zbtb7c

DIOPT Version :9

Sequence 1:	NP_572823.1	Gene:	CG15725 / 32224	FlyBaseID:	FBgn0030417	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_036016934.1	Gene:	Zbtb7c / 207259	MGIID:	2443302	Length:	625	Species:	Mus musculus

Alignment Length:	703	Identity:	123/703 - (17%)
Similarity:	200/703 - (28%)	Gaps:	275/703 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ATALVMSSPPDVILEVGPAPSNVRFVAHSLVLGMHSGYLRSAIR-LDETAAGTAASVSASASISI 102
            |.|..|::..|.::.: |.|::...|..||....|:|.|...:. :.|....|..||
Mouse     2 ALAENMANDIDELIGI-PFPNHSSEVLCSLNEQRHAGLLCDVLLVVQEQEYRTHRSV-------- 57

  Fly   103 TGATAASCNPSSSSSAASSSSSAVTTASGELLLYLSNVTADQFAPLLTYMYTGYLDLNVDNIFAV 167
                .|:|     |.......:|.:.||...:..:..|..:..|.:|.:.||..|.:...|:
Mouse    58 ----LAAC-----SKYFKKLFTAGSLASQPYVYEIDFVQPEALAAILEFAYTSTLTITASNV--- 110

  Fly   168 LLATHVLHMPRALEI-CRSFLARAQTEGYLNGNPAAQLCPVPSIPAKIIRPIPSKATMPNFGFLP 231
               .|:|:..|.||| |                       :.::..:|:.|
Mouse   111 ---KHILNAARMLEIQC-----------------------IVNVCLEIMEP-------------- 135

  Fly   232 LPQAPPSVAPSAQPTAHQPTTGIAPVASASILSSFGTNTQHMEHMEQPIAMLDNEVDEEDVEVFI 296
                                 |          .|.|......|..|.     |::.||:|.|
Mouse   136 ---------------------G----------GSVGEEDDKEEEDED-----DDDEDEDDEE--- 161

  Fly   297 DSNTVTDNEAEELEPDVDMDCNVSVVSSLAASSAGSMNIERLDVKPPTPIPVSVATIISATTTKS 361
                  :.|.||.|.:.|.:           ..|...|:       |.|      ..|:...:.|
Mouse   162 ------EEEEEEEEEEDDPE-----------DFADQENL-------PDP------QDITCPQSPS 196

  Fly   362 QAQSLGQSKGQNSRR------ESNSKGN----RTKSSASRSRKSSGLQVAKAPVPAAQLDLTAAA 416
            :...|.:....::.|      :..|.|:    |..|..|..|::   ...||.:|..:..|:..|
Mouse   197 KTDHLTEKDYSDTPRDFPDSFQPGSPGHLGVIRDFSIESLLREN---LYPKANIPDRRPSLSPFA 258

  Fly   417 TPSITSSKFIIDVASCDGPVRFRRILNTAYGHKPEAMESNALAGPATAPAGGSSNSTISEQHRSQ 481
                                             ||..       |...|.|..:.:.:.||....
Mouse   259 ---------------------------------PEFF-------PHLWPGGFGAFAQLPEQPMDS 283

  Fly   482 QSVSLSFHQQMARAISSQQRQLSHQQQEE----------SENSGDAIPATIGKQHATGATAASSA 536
            ..:.|..          :.|::..:.:||          |:...|..|...|  ...|...|.:.
Mouse   284 GPLDLVI----------KNRKIKEEDKEELAPPPPPPFSSDFFKDMFPDLPG--GPLGPIKAEND 336

  Fly   537 MST-----SSTHAGS---------NRKSQATGT-----------GTGSGSATASSAGNQELYVCV 576
            ...     |:||.||         .||.:...:           |.|.......:...::.|:|.
Mouse   337 YGAYLNFLSATHLGSLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPYMCS 401

  Fly   577 YCKHTFKSQYCYQKHAKRHLNPLTLTTNDKKLLMESAASMANTIEMDNPSSVGQSGANNSSGSIA 641
            .|:..|..|...:.|.::|      |.....|.:...|...:..::.|..            .|.
Mouse   402 ICEVRFTRQDKLKIHMRKH------TGERPYLCIHCNAKFVHNYDLKNHM------------RIH 448

  Fly   642 TGNGATAVAATTALLRREVRPLDMNVQYYPCKTCGSKFPSYYFVHKH--RKMC 692
            ||                |||       |.|:.|...|.....:|:|  |:.|
Mouse   449 TG----------------VRP-------YQCEFCYKSFTRSDHLHRHIKRQSC 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15725	NP_572823.1	BTB	49..189	CDD:197585	33/141 (23%)
		BTB	49..187	CDD:279045	33/139 (24%)
		zf-C2H2	573..595	CDD:278523	6/21 (29%)
Zbtb7c	XP_036016934.1	BTB_POZ_ZBTB7C_ZBTB36	15..134	CDD:349637	33/165 (20%)
		C2H2 Zn finger	372..392	CDD:275368	2/19 (11%)
		SFP1	<386..474	CDD:227516	23/128 (18%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	428..448	CDD:275368	2/31 (6%)
		C2H2 Zn finger	456..474	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46105
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100