DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15725 and Zbtb7a

DIOPT Version :10

Sequence 1:NP_572823.1 Gene:CG15725 / 32224 FlyBaseID:FBgn0030417 Length:745 Species:Drosophila melanogaster
Sequence 2:NP_034861.3 Gene:Zbtb7a / 16969 MGIID:1335091 Length:569 Species:Mus musculus


Alignment Length:600 Identity:105/600 - (17%)
Similarity:159/600 - (26%) Gaps:248/600 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 VTADQFAPLLTYMYTGYLDLNVDNIFAVLLATHVLHMPRALEICRSFLAR-----------AQTE 193
            |:|:....|:.:.||..|.::..|:..:|.|..:|.:|....:|...|.|           :|.:
Mouse    80 VSAEALTALMDFAYTATLTVSTANVGDILSAARLLEIPAVSHVCADLLERQILAADDVGDASQPD 144

  Fly   194 GYLNGNPAAQLCPVPSIPAKIIRPIPSKATMPNFGFLPLPQAPPSVAPSAQPTAHQPTTGIAPVA 258
            |   ..|..|        ..::|   :|..:..|...|:...||:..|                 
Mouse   145 G---AGPTDQ--------RNLLR---AKEYLEFFRSNPMNSLPPTAFP----------------- 178

  Fly   259 SASILSSFGTNTQHMEHMEQPIAMLDNEVDEEDVEVFIDSNTVTDNEAEELEPDVDMDC-NVSVV 322
                .|.||.                                          ||.|:|. ..:|.
Mouse   179 ----WSGFGA------------------------------------------PDDDLDATKEAVA 197

  Fly   323 SSLAASSAGSMNIERLDVKPPTPIPVSVATIISATTTKSQAQSLGQSKGQNSRRESNSKGNRTKS 387
            :::||.:||..|  .||...|.|                                          
Mouse   198 AAVAAVAAGDCN--GLDFYGPGP------------------------------------------ 218

  Fly   388 SASRSRKSSGLQVAKAP---------VPAAQLDLTAAATPSITSSKFIIDVASCDGPVRFRRILN 443
            .|.|.....|.:....|         .|...|.....|.|:.|.                    |
Mouse   219 PADRPPAGDGDEGDSTPGLWPERDEDAPPGGLFPPPTAPPATTQ--------------------N 263

  Fly   444 TAYGHKPEAM-ESNALAGPATAPAGGSSNSTISEQHRSQQS--------VSLSFHQQMARAISSQ 499
            ..||...... |..|.|....||..|.|...:|.....:..        .:.:..|||..::.. 
Mouse   264 GHYGRAGAGTGEEEAAALSEAAPEPGDSPGFLSGAAEGEDGDAADVDGLAASTLLQQMMSSVGR- 327

  Fly   500 QRQLSHQQQEESE-----------------NSGDAIPATIGK-QHATGATAASSAMSTSSTHAGS 546
                :....|||.                 :.||..||...| :....|.|............|:
Mouse   328 ----AGDSDEESRTDDKGVMDYYLKYFSGAHEGDVYPAWSQKGEKKIRAKAFQKCPICEKVIQGA 388

  Fly   547 NRKSQATGTGTGSGSATASSAGNQELYVCVYCKHTFKSQYCYQKHAKRHLNPLTLTTNDKK-LLM 610
            .:..:...|.||           ::.|.|..||..|..|...:.|.::|       |.:|. |..
Mouse   389 GKLPRHIRTHTG-----------EKPYECNICKVRFTRQDKLKVHMRKH-------TGEKPYLCQ 435

  Fly   611 ESAASMANTIEMDNPSSVGQSGANNSSGSIATGNGATAVAATTALLRREVRPLDMNVQYYPCKTC 675
            :..|:.|:..::.|...|            .||                :||       |.|.:|
Mouse   436 QCGAAFAHNYDLKNHMRV------------HTG----------------LRP-------YQCDSC 465

  Fly   676 GSKFPSYYFVHKHRK 690
            ...|.....:|:|.|
Mouse   466 CKTFVRSDHLHRHLK 480

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG15725NP_572823.1 BTB_POZ 49..187 CDD:453885 12/46 (26%)
PRK14959 <192..>272 CDD:184923 13/79 (16%)
ZnF_C2H2 573..595 CDD:197676 7/21 (33%)
Zbtb7aNP_034861.3 BTB_POZ_ZBTB7A 9..128 CDD:349635 12/47 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..304 22/151 (15%)
Mediates interaction with KHDRBS1. /evidence=ECO:0000250|UniProtKB:O95365 275..569 50/263 (19%)
Mediates interaction with RELA. /evidence=ECO:0000269|PubMed:29813070 343..569 36/190 (19%)
Mediates interaction with SMAD4. /evidence=ECO:0000250|UniProtKB:O95365 371..569 31/162 (19%)
C2H2 Zn finger 378..398 CDD:275368 1/19 (5%)
zf-H2C2_2 393..415 CDD:463886 8/32 (25%)
C2H2 Zn finger 406..426 CDD:275368 6/19 (32%)
zf-H2C2_2 419..443 CDD:463886 6/30 (20%)
C2H2 Zn finger 434..454 CDD:275368 4/31 (13%)
zf-H2C2_2 446..471 CDD:463886 10/59 (17%)
C2H2 Zn finger 462..480 CDD:275368 5/17 (29%)