DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15725 and NACC2

DIOPT Version :9

Sequence 1:	NP_572823.1	Gene:	CG15725 / 32224	FlyBaseID:	FBgn0030417	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_653254.1	Gene:	NACC2 / 138151	HGNCID:	23846	Length:	587	Species:	Homo sapiens

Alignment Length:	476	Identity:	90/476 - (18%)
Similarity:	149/476 - (31%)	Gaps:	169/476 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 FVAHSLVLGMHSGYLRSAIRLDETAAGTAASVSASASISITGATAASCNPSSSSSAASSSSSAVT 127
            |.||..||...|.|.|...           |.::.::..:.|:...:|
Human    41 FKAHRAVLAASSLYFRDLF-----------SGNSKSAFELPGSVPPAC----------------- 77

  Fly   128 TASGELLLYLSNVTADQFAPLLTYMYTGYLDLNVDNIFAVLLATHVLHMPRALE----------- 181
                             |..:|::.|||.|.:.......|:.....|.:...:|
Human    78 -----------------FQQILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSS 125

  Fly   182 -ICRSFLARAQTEGYLNGNPAAQLCPV----------PSIPAKIIRPIPSKATMPNFGFLPLPQA 235
             .|.|..|..:..|....:|..||.|.          ||:|..::..:..:|       :.||.|
Human   126 PHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPLLTRVKHEA-------MELPPA 183

  Fly   236 PPSVAPSAQPTAHQPTTGIAPVASASI----------------LSSFGTNTQHMEHMEQP----- 279
            .|.:||. :|....|..|:|..|.|::                :.|..|....::.|..|
Human   184 GPGLAPK-RPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERT 247

  Fly   280 ------IAMLD------NEVDEEDVEVFIDSNTVTDNEAEELEPDVDMDCNVSVVSSLAASSAGS 332
                  :...|      ||.||||.|.:       |...||            ....:...::||
Human   248 SPGASSLPTTDSPTSYHNEEDEEDDEAY-------DTMVEE------------QYGQMYIKASGS 293

  Fly   333 MNIERLDVKPPTPIPV-SVATIISATTTKSQAQSLGQSKGQNSRRESNSKGNRTKSSASRSRKSS 396
            ..::    :.|.|:|: |.:.::......:...||....|.....:..|:|:
Human   294 YAVQ----EKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGD------------- 341

  Fly   397 GLQVAKAPVPAAQLDLTAAATPSITSSKFIIDVASCDG---PVRFRRILNTAYGHKPEAMESNAL 458
                     |..:|:|.|.:...||..: :::...|.|   .|..||:|.|.:       :.|.|
Human   342 ---------PGEKLELVAGSGVYITRGQ-LMNCHLCAGVKHKVLLRRLLATFF-------DRNTL 389

  Fly   459 AGPATAPAGGSSNSTISEQHR 479
            |.    ..|....|:.|:..|
Human   390 AN----SCGTGIRSSTSDPSR 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15725	NP_572823.1	BTB	49..189	CDD:197585	22/137 (16%)
		BTB	49..187	CDD:279045	22/135 (16%)
		zf-C2H2	573..595	CDD:278523
NACC2	NP_653254.1	BTB	20..120	CDD:279045	20/123 (16%)
		BTB	31..114	CDD:197585	19/117 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..272		7/31 (23%)
		BEN	373..450	CDD:214981	12/45 (27%)
		TIM_phosphate_binding	496..>581	CDD:304361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46105
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100