DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15725 and Zbtb7a

DIOPT Version :9

Sequence 1:	NP_572823.1	Gene:	CG15725 / 32224	FlyBaseID:	FBgn0030417	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_006240898.1	Gene:	Zbtb7a / 117107	RGDID:	620946	Length:	648	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	134/740 - (18%)
Similarity:	212/740 - (28%)	Gaps:	285/740 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RSNAAGIVGAGNVTPSGV----SATALV----MSSPP--DVILEVG---PAPSNVRFVAHS--LV 69
            |:.|.|..|.|:.:|:|.    .|.|:|    ..:||  :|..::.   ..|..:.|..||  ::
  Rat    36 RAAAEGGAGPGSASPAGARSHQPAAAIVPVAGARAPPAKEVSRKMAGGVDGPIGIPFPDHSSDIL 100

  Fly    70 LGMH----SGYLRSAIRLDE-TAAGTAASVSASAS-----ISITGATAASCNPSSSSSAASSSSS 124
            .|::    .|.|...:.|.| ....|..||.|:.|     :..:||.....|
  Rat   101 SGLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQN------------- 152

  Fly   125 AVTTASGELLLYLSNVTADQFAPLLTYMYTGYLDLNVDNIFAVLLATHVLHMPRALEICRSFLAR 189
                     :..:..|:|:....|:.:.||..|.::..|:..:|.|..:|.:|....:|...|.|
  Rat   153 ---------VYEIDFVSAEALTALMDFAYTATLTVSTANVGDILSAARLLEIPAVSRVCTDLLER 208

  Fly   190 AQTEGYLNGNPAAQLCPVPSIPAKIIRPIPSKATMPNFGFLPLPQAPPSVAPSAQPTAHQPTTGI 254
                                   :|:                   |...|..:.||      .|.
  Rat   209 -----------------------QIL-------------------AADDVGDAGQP------DGA 225

  Fly   255 APVASASILSSFGTNTQHMEHMEQPIAMLDNEVDEEDVEVFIDSNTVTDNEAEELE------PDV 313
            .|....::|.:       .|::|                 |..||.:........:      ||.
  Rat   226 GPTDQRNLLRA-------KEYLE-----------------FFRSNPMNSLPPTAFQWPGFSAPDD 266

  Fly   314 DMDC-NVSVVSSLAASSAGSMNIERLDVKPPTPIPVSVATIISATTTKSQAQSLGQSKGQNSRRE 377
            |:|. ..:|.:::||.:||..|  .||...|.|
  Rat   267 DLDATKEAVAAAVAAVAAGDCN--GLDFYGPGP-------------------------------- 297

  Fly   378 SNSKGNRTKSSASRSRKSSGLQVAKAP---------VPAAQLDLTAAATPSITSSKFIIDVASCD 433
                      .|.|.....|.:....|         .|...|.....|.|:.|.
  Rat   298 ----------PADRPPTGDGEEGDSTPGLWPERDEDAPPGGLFPPPTAPPATTQ----------- 341

  Fly   434 GPVRFRRILNTAYGHKPEAM-ESNALAGPATAPAGGSSNSTISEQHRSQQS--------VSLSFH 489
                     |..||....:. |..|:|....||..|.|...:|.....:..        .:.:..
  Rat   342 ---------NGHYGRAGASTGEEEAVALSEAAPEPGDSPGFLSGAAEGEDGDAADVDGLAASTLL 397

  Fly   490 QQMARAISSQQRQLSHQQQEESE-----------------NSGDAIPATIGK-QHATGATAASSA 536
            |||..::..     :....|||.                 :.||..||...| :....|.|....
  Rat   398 QQMMSSVGR-----AGDSDEESRPDDKGVMDYYLKYFSGAHEGDVYPAWSQKGEKKIRAKAFQKC 457

  Fly   537 MSTSSTHAGSNRKSQATGTGTGSGSATASSAGNQELYVCVYCKHTFKSQYCYQKHAKRHLNPLTL 601
            ........|:.:..:...|.||           ::.|.|..||..|..|...:.|.::|
  Rat   458 PICEKVIQGAGKLPRHIRTHTG-----------EKPYECNICKVRFTRQDKLKVHMRKH------ 505

  Fly   602 TTNDKK-LLMESAASMANTIEMDNPSSVGQSGANNSSGSIATGNGATAVAATTALLRREVRPLDM 665
             |.:|. |..:..|:.|:..::.|...|            .||                :||
  Rat   506 -TGEKPYLCQQCGAAFAHNYDLKNHMRV------------HTG----------------LRP--- 538

  Fly   666 NVQYYPCKTCGSKFPSYYFVHKHRK 690
                |.|.:|...|.....:|:|.|
  Rat   539 ----YQCDSCCKTFVRSDHLHRHLK 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15725	NP_572823.1	BTB	49..189	CDD:197585	31/154 (20%)
		BTB	49..187	CDD:279045	30/152 (20%)
		zf-C2H2	573..595	CDD:278523	7/21 (33%)
Zbtb7a	XP_006240898.1	BTB	103..206	CDD:279045	24/124 (19%)
		BTB	114..210	CDD:197585	24/140 (17%)
		COG5048	455..>518	CDD:227381	15/80 (19%)
		C2H2 Zn finger	457..477	CDD:275368	1/19 (5%)
		zf-H2C2_2	472..494	CDD:290200	8/32 (25%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	498..522	CDD:290200	6/30 (20%)
		C2H2 Zn finger	513..533	CDD:275368	4/31 (13%)
		zf-H2C2_2	525..550	CDD:290200	10/59 (17%)
		C2H2 Zn finger	541..559	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46105
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100