DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15725 and NACC1

DIOPT Version :9

Sequence 1:	NP_572823.1	Gene:	CG15725 / 32224	FlyBaseID:	FBgn0030417	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_443108.1	Gene:	NACC1 / 112939	HGNCID:	20967	Length:	527	Species:	Homo sapiens

Alignment Length:	490	Identity:	93/490 - (18%)
Similarity:	148/490 - (30%)	Gaps:	186/490 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 FVAHSLVLGMHSGYLRSAIRLDETAAGTAASVSASASISITGATAASCNPSSSSSAASSSSSAVT 127
            |.||..||...|.|.|...                               ::|.||.....:||.
Human    41 FKAHRAVLAASSSYFRDLF-------------------------------NNSRSAVVELPAAVQ 74

  Fly   128 TASGELLLYLSNVTADQFAPLLTYMYTGYLDLNVDNIFAVLLATHVLHMPRALEICRSFLAR--- 189
            ..|              |..:|::.|||.|.:||.:.|.::.....|.:...:|....|..:
Human    75 PQS--------------FQQILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLKVSS 125

  Fly   190 ----------------------AQTEGYLNGNPAAQLCPVPSI--------PAKIIRPIP----- 219
                                  |||.|:    ||.. .|:|.:        .:..::.:|
Human   126 PSCDSQGLHAEEAPSSEPQSPVAQTSGW----PACS-TPLPLVSRVKTEQQESDSVQCMPVAKRL 185

  Fly   220 ------------------SKATMPNFGF-----LPLPQAPPSVAPSAQPT----AHQPTTGIAPV 257
                              :|.:.|:...     .|.||..|.|| :|||.    |.||..|:|..
Human   186 WDSGQKEAGGGGNGSRKMAKFSTPDLAANRPHQPPPPQQAPVVA-AAQPAVAAGAGQPAGGVAAA 249

  Fly   258 A------SASILSSFGTNTQHMEHMEQPIAMLDNEVDEEDVEVFIDSNTVTDNEAEELEPDVDMD 316
            .      |.|..:|.||::.:..  :.| ....||.|||:           |...|.::......
Human   250 GGVVSGPSTSERTSPGTSSAYTS--DSP-GSYHNEEDEEE-----------DGGEEGMDEQYRQI 300

  Fly   317 CNVSVVSSLAASSAGSMNI----ERLDVKPPTPIPVSVATIISATTTKSQAQSLGQSKGQNSRRE 377
            ||:..:.|:       ||:    |:::..|....|.|...|.......|....|....|.....:
Human   301 CNMYTMYSM-------MNVGQTAEKVEALPEQVAPESRNRIRVRQDLASLPAELINQIGNRCHPK 358

  Fly   378 SNSKGNRTKSSASRSRKSSGLQVAKAPVPAAQLDLTAAATPSITSSKFIIDVASCD------GPV 436
            ...:|:                      |:.:|:|.......||.::.:    :|.      ..|
Human   359 LYDEGD----------------------PSEKLELVTGTNVYITRAQLM----NCHVSAGTRHKV 397

  Fly   437 RFRRILNTAYGHKPEAMESNALAGPATAPAGGSSN 471
            ..||:|.:.:       :.|.||.........|:|
Human   398 LLRRLLASFF-------DRNTLANSCGTGIRSSTN 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15725	NP_572823.1	BTB	49..189	CDD:197585	26/125 (21%)
		BTB	49..187	CDD:279045	25/123 (20%)
		zf-C2H2	573..595	CDD:278523
NACC1	NP_443108.1	BTB_POZ_BTBD14B_NAC1	3..125	CDD:349599	26/128 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..153		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..292		26/96 (27%)
		BEN	396..474	CDD:214981	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46105
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100