Protein Alignment Tis11 and ZFP36

DIOPT Version :9

• Sequence 1: NP_001259490.1
• Gene: Tis11 / 32222
• FlyBaseID: FBgn0011837
• Length: 436
• Species: Drosophila melanogaster
• Sequence 2: NP_003398.3
• Gene: ZFP36 / 7538
• HGNCID: 12862
• Length: 326
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 106/324 - (32%)
• Similarity: 124/324 - (38%)
• Gaps: 105/324 - (32%)

  Fly   118 ERTQSEPLPPQQPMNTSRYKTELCRPFEEAGECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTF 182
            |.:.|...|.......|||||||||.|.|:|.|:||.|||||||..|||..:||||||||.|..|
Human    86 ELSPSPTSPTATSTTPSRYKTELCRTFSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKF 150

  Fly   183 HSVGFCPYGPRCHFVHNADEARAQQAAQAAKSSTQSQSQSQQSSSQNFSPKSNQSSNQSSNSSSS 247
            :..|.||||.||||:||..|..|  |........||.|.|...|.:..||.....:..|.:|||.
Human   151 YLQGRCPYGSRCHFIHNPSEDLA--APGHPPVLRQSISFSGLPSGRRTSPPPPGLAGPSLSSSSF 213

  Fly   248 SSSSGGGGGGGNSINNNNGSQFYLPLSPPLSMSTGSDRESPTGSLSLSPTNSLTSFPFHDALQHG 312
            |.||                      |||           |.|.|.|||
Human   214 SPSS----------------------SPP-----------PPGDLPLSP---------------- 229

  Fly   313 YLASNGAKSNSSASSTSSASGMGLGMSMGIGQGMIIGQGLGMGHHGPATPPESPN----VPISP- 372
                         |:.|:|.|..|                  ....| ||...|:    .|||.
Human   230 -------------SAFSAAPGTPL------------------ARRDP-TPVCCPSCRRATPISVW 262

  Fly   373 ------VHTP-------PPYDVVVSGSGAGNNSVGSKQLLQKSVSTPMQQEDTP-RLPVFNRLS 422
                  |.||       .|.:...|||..|.:   ...:.:..|..|.|....| |||:|||:|
Human   263 GPLGGLVRTPSVQSLGSDPDEYASSGSSLGGS---DSPVFEAGVFAPPQPVAAPRRLPIFNRIS 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_001259490.1	zf-CCCH	136..161	CDD:279036	18/24 (75%)
		zf-CCCH	174..198	CDD:279036	15/23 (65%)
ZFP36	NP_003398.3	Necessary for localization of ARE-containing mRNAs to processing bodies (PBs). /evidence=ECO:0000269|PubMed:17369404	1..174		51/89 (57%)
		Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation. /evidence=ECO:0000269|PubMed:15687258	1..100		3/13 (23%)
		Necessary for nuclear export. /evidence=ECO:0000250|UniProtKB:P47973	1..15
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..66
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..102		3/15 (20%)
		Necessary for nuclear localization. /evidence=ECO:0000250|UniProtKB:P47973	95..168		45/72 (63%)
		Necessary for RNA-binding. /evidence=ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:12748283	97..173		47/75 (63%)
		Necessary for localization of ARE-containing mRNAs to processing bodies (PBs). /evidence=ECO:0000269|PubMed:17369404	100..326		103/310 (33%)
		Necessary for interaction with PABPN1. /evidence=ECO:0000250|UniProtKB:P22893	103..194		53/92 (58%)
		zf-CCCH	<104..>200	CDD:325094	54/97 (56%)
		Necessary for mRNA decay activation. /evidence=ECO:0000269|PubMed:15687258	174..326		55/234 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..245		28/149 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..292		4/18 (22%)
		Interaction with CNOT1. /evidence=ECO:0000269|PubMed:23644599	312..326		8/12 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2657
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000616
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2078
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820