DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tis11 and ZFP36L2

DIOPT Version :9

Sequence 1:	NP_001259490.1	Gene:	Tis11 / 32222	FlyBaseID:	FBgn0011837	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_008818.3	Gene:	ZFP36L2 / 678	HGNCID:	1108	Length:	494	Species:	Homo sapiens

Alignment Length:	382	Identity:	121/382 - (31%)
Similarity:	163/382 - (42%)	Gaps:	130/382 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 MNTSRYKTELCRPFEEAGECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCH 195
            :|::||||||||||||:|.||||||||||||.||||::.||||||||.|||||::||||||||||
Human   149 INSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCH 213

  Fly   196 FVHNADEARAQQAAQAAKS----STQS--------QSQSQQSSSQNF------------------ 230
            |:|||||.|...:..|:..    .|:.        :.:.:...|.:|
Human   214 FIHNADERRPAPSGGASGDLRAFGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPL 278

  Fly   231 ---SPKSNQSSNQSSNSSSSSSSSGGGGGGGNSINNNNGSQFYLPLSPPLSMSTGSDRESPTGSL 292
               ||.|......|.:|:||.|||..                        |.|:.|...:|:|:.
Human   279 LLDSPTSRTPPPPSCSSASSCSSSAS------------------------SCSSASAASTPSGAP 319

  Fly   293 SLSPTNSLTSFPFHDALQHGY-----LASNGA--KSNSSASSTSSASGMGLGMSMGI-------- 342
            :...:.:..:..   ||.:|.     |.:.||  .:.||||..::|...|..:|..|
Human   320 TCCASAAAAAAA---ALLYGTGGAEDLLAPGAPCAACSSASCANNAFAFGPELSSLITPLAIQTH 381

  Fly   343 ------------GQGMIIGQGLGMGHHGPATPPESPNVPI----------------------SPV 373
                        .|.....|||.    .||.||..|:..:                      |||
Human   382 NFAAVAAAAYYRSQQQQQQQGLA----PPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPV 442

  Fly   374 HTPPP--------YDVVVSGSGAGNNSVGSKQLLQKSVSTPMQQEDTPRLPVFNRLS 422
            ...||        .|..:|||.:..:..||:        :| ..:...|||:|:|||
Human   443 FDAPPSPPDSLSDRDSYLSGSLSSGSLSGSE--------SP-SLDPGRRLPIFSRLS 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_001259490.1	zf-CCCH	136..161	CDD:279036	22/24 (92%)
Tis11	NP_001259490.1	zf-CCCH	174..198	CDD:279036	20/23 (87%)
ZFP36L2	NP_008818.3	Tis11B_N	3..131	CDD:282420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..113
		RNA-binding. /evidence=ECO:0000269\|PubMed:14981510, ECO:0000269\|PubMed:20506496	153..158		4/4 (100%)
		zf-CCCH	154..179	CDD:279036	22/24 (92%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:14981510, ECO:0000269\|PubMed:20506496	170..211		33/40 (83%)
		zf-CCCH	192..216	CDD:279036	20/23 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..293		5/35 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..494		27/107 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10475
eggNOG	1	0.900	-	-		E1_COG5063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000616
OrthoInspector	1	1.000	-	-		otm41180
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2078
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.900