Protein Alignment Tis11 and ZFP36L1

DIOPT Version :9

• Sequence 1: NP_001259490.1
• Gene: Tis11 / 32222
• FlyBaseID: FBgn0011837
• Length: 436
• Species: Drosophila melanogaster
• Sequence 2: NP_001231630.1
• Gene: ZFP36L1 / 677
• HGNCID: 1107
• Length: 407
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 134/409 - (32%)
• Similarity: 186/409 - (45%)
• Gaps: 107/409 - (26%)

  Fly    36 FDCNEVR-KEIRML-----LAHGANLDQQHQQQPHRHHGGLTR--TISQPAQLIQQQQQQHQQQQ 92
            ||.:||. |..:||     .|.|..||::....|  ..||..|  :::.|:....|.|.....:.
Human    80 FDLSEVLCKGNKMLNYSAPSAGGCLLDRKAVGTP--AGGGFPRRHSVTLPSSKFHQNQLLSSLKG 142

  Fly    93 QQQPAVASLVTITENLGNMNLHRKLERTQSEP----LPPQ-QP----MNTSRYKTELCRPFEEAG 148
            :..||::|..:           |..:|:.||.    ||.| ||    :|:|||||||||||||.|
Human   143 EPAPALSSRDS-----------RFRDRSFSEGGERLLPTQKQPGGGQVNSSRYKTELCRPFEENG 196

  Fly   149 ECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCHFVHNADEARAQQAAQAAK 213
            .||||:|||||||.||||::.||||||||.|||||::|||||||||||:|||:|.|   |...|:
Human   197 ACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERR---ALAGAR 258

  Fly   214 SSTQSQSQSQQSSSQNFSPKSNQSSNQSSNSSSSSSSSGGGGGGGNSINNNNGSQFYLPLSPPLS 278
            ..:..:.:.|.|.|  |:...:.::..::.....|.:|                     ::||..
Human   259 DLSADRPRLQHSFS--FAGFPSAAATAAATGLLDSPTS---------------------ITPPPI 300

  Fly   279 MSTGSDRESPTGSLSLSPTNSLTSFPFHDALQHGYLASNGAKSNSSASSTSSASGMGLGMSMGIG 343
            :|......|||     .|..:...|.|                :|...::..|..|||
Human   301 LSADDLLGSPT-----LPDGTNNPFAF----------------SSQELASLFAPSMGL------- 337

  Fly   344 QGMIIGQGLGMGHHGPAT-----PPESPNVPISPVHTPPPYDVVVSGSGAGNNSVGSKQLLQKSV 403
                      .|...|.|     ..|||::..||   |.|.|.:....|..::|..|     .|.
Human   338 ----------PGGGSPTTFLFRPMSESPHMFDSP---PSPQDSLSDQEGYLSSSSSS-----HSG 384

  Fly   404 STPMQQEDTPRLPVFNRLS 422
            |.....:::.|||:|:|||
Human   385 SDSPTLDNSRRLPIFSRLS 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_001259490.1	zf-CCCH	136..161	CDD:279036	21/24 (88%)
		zf-CCCH	174..198	CDD:279036	20/23 (87%)
ZFP36L1	NP_001231630.1	Tis11B_N	72..168	CDD:282420	25/100 (25%)
		zf-CCCH	184..209	CDD:279036	21/24 (88%)
		zf-CCCH	222..246	CDD:279036	20/23 (87%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10475
eggNOG	1	0.900	-	-		E1_COG5063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000616
OrthoInspector	1	1.000	-	-		otm41180
orthoMCL	1	0.900	-	-		OOG6_101179
Panther	1	1.100	-	-	LDO	PTHR12547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2078
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.800