DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tis11 and zfp36l1a

DIOPT Version :9

Sequence 1:	NP_001259490.1	Gene:	Tis11 / 32222	FlyBaseID:	FBgn0011837	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_001070621.2	Gene:	zfp36l1a / 561280	ZFINID:	ZDB-GENE-030131-9860	Length:	374	Species:	Danio rerio

Alignment Length:	432	Identity:	136/432 - (31%)
Similarity:	184/432 - (42%)	Gaps:	116/432 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FDCNEVRKEIRMLLAHGANLDQQHQQQPHRHH---GGLTRTISQPAQLIQQQ------------Q 85
            ||.:|:......:|.:..|:    ...||...   .|.:.:||.|...:..:            |
Zfish    10 FDFSEMINNKNKMLNYNNNI----LSSPHPVSVPCTGTSLSISNPTGCLLDRKAVGTPSTGGVYQ 70

  Fly    86 QQH---------QQQQQQQPAVAS---LVTITENLGNMNLHRKL-ERTQSE-----------PLP 126
            ::|         .|.|....|.|.   |.:.|...|:.|...:| :|:.||           |..
Zfish    71 RRHSVTSANTKLNQNQFLNIAKADPSLLGSGTGTTGSSNKENRLRDRSFSETGDRLLQKCSGPGG 135

  Fly   127 PQQPMNTSRYKTELCRPFEEAGECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYG 191
            |...:|:|||||||||||||.|.||||:|||||||.||||::.||||||||.|||||::||||||
Zfish   136 PNSQVNSSRYKTELCRPFEENGACKYGDKCQFAHGIHELRSLSRHPKYKTELCRTFHTIGFCPYG 200

  Fly   192 PRCHFVHNADEARAQQAAQAAKSSTQSQSQSQQSSSQNFSPKSNQSSNQSSNSSSSSSSSGGGGG 256
            |||||:|||:|.|......:..|:               |.|..:...|.|.|.:...||||...
Zfish   201 PRCHFIHNAEERRGPPPTPSPLSA---------------SNKMERPRLQHSYSFAGFPSSGGLRD 250

  Fly   257 GGNSINNNNGSQFYLPLSPPLSMSTGSDRESPTGSLSLSPTNSLTSFPFHDALQHGYLASNGAKS 321
            ...|:            :||...|.....|.|:.:.....:..|.:| |..:|.:..|:.:...|
Zfish   251 SPTSV------------TPPPIFSPDELPEWPSSNPFTYSSQELANF-FSPSLGNAPLSCSDPSS 302

  Fly   322 NSSASSTSSASGMGLGMSMGIGQGMIIGQGLGMGHHGPATP------PESPNVPISPVHTPPPYD 380
            .:..|.||                               ||      .||||:..||...|   |
Zfish   303 QAPPSPTS-------------------------------TPFYFRAMSESPNLYESPSSQP---D 333

  Fly   381 VVVSGSGAGNNSVGSKQLLQKSVSTPMQQEDTPRLPVFNRLS 422
            .:....|..::|.||   |..|.|..:  :.|.|||:|:|||
Zfish   334 SLSDQEGYQSSSSGS---LSGSESPVL--DTTRRLPIFSRLS 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_001259490.1	zf-CCCH	136..161	CDD:279036	21/24 (88%)
Tis11	NP_001259490.1	zf-CCCH	174..198	CDD:279036	20/23 (87%)
zfp36l1a	NP_001070621.2	Tis11B_N	3..127	CDD:282420	25/120 (21%)
		zf-CCCH	145..170	CDD:279036	21/24 (88%)
		zf-CCCH	183..207	CDD:279036	20/23 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10435
eggNOG	1	0.900	-	-		E1_COG5063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4153
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000616
OrthoInspector	1	1.000	-	-		otm25344
orthoMCL	1	0.900	-	-		OOG6_101179
Panther	1	1.100	-	-	LDO	PTHR12547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2078
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.850