DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tis11 and zfp36l2

DIOPT Version :9

Sequence 1:	NP_001259490.1	Gene:	Tis11 / 32222	FlyBaseID:	FBgn0011837	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	XP_005156327.1	Gene:	zfp36l2 / 333941	ZFINID:	ZDB-GENE-030131-5873	Length:	373	Species:	Danio rerio

Alignment Length:	356	Identity:	126/356 - (35%)
Similarity:	163/356 - (45%)	Gaps:	98/356 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 QQQQQHQQQQQQQPAVASLVTITENLGNMNLHRKLERTQSEPLPPQQPMNTSRYKTELCRPFEEA 147
            ::.||.|:..||:|.                               ..:|::||||||||||||.
Zfish    96 ERSQQLQEMLQQKPG-------------------------------SQINSTRYKTELCRPFEEN 129

  Fly   148 GECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCHFVHNADEARAQQAAQAA 212
            |.||||||||||||.|||||:.||||||||.|||||::|||||||||||:|||||.||......|
Zfish   130 GSCKYGEKCQFAHGYHELRNLSRHPKYKTEPCRTFHTIGFCPYGPRCHFIHNADERRAATNNTQA 194

  Fly   213 KSSTQSQSQSQQSSSQNF-----SPKSNQSSNQSSNSSSSSSSSGGGGGGGNSINNNNGSQFYLP 272
            :.|.:.....::.||..|     .||.:.|.:.|..|||.||.:.       .|:|
Zfish   195 RLSQELGILGEKESSNPFLRPRERPKLHHSLSFSGFSSSRSSDTA-------LIDN--------- 243

  Fly   273 LSPPLSMSTGSDRESPTGSLSLSPTN-SLTSFPFHDALQHGYLASNGAKSNSSA-SSTSSASGMG 335
               |.|      |..|..:.||:||: .|.:|.|.|.....:||.....:.||: .|....:|.
Zfish   244 ---PTS------RTPPPPNCSLTPTSPCLNAFTFPDQDLKAFLAPIIPHTQSSSLYSNIQTNGC- 298

  Fly   336 LGMSMGIGQGMIIGQGLGMGHHGPATPP----ESPNV-PI--SPVHTPPPY--DVVVSGSGAGNN 391
                                   |.:||    ..|:: |:  |||...||.  |.:....|..:.
Zfish   299 -----------------------PPSPPFKMSHLPSMYPLSESPVFDSPPSPPDSLSDPEGYLSG 340

  Fly   392 SVGSKQLLQKSVSTPMQQEDTPRLPVFNRLS 422
            |..|...:..|.|..|  :...|||:|:|||
Zfish   341 SCCSSGTISGSESPSM--DANRRLPIFSRLS 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_001259490.1	zf-CCCH	136..161	CDD:279036	22/24 (92%)
Tis11	NP_001259490.1	zf-CCCH	174..198	CDD:279036	20/23 (87%)
zfp36l2	XP_005156327.1	Tis11B_N	3..99	CDD:282420	0/2 (0%)
		zf-CCCH	118..143	CDD:279036	22/24 (92%)
		zf-CCCH	156..180	CDD:279036	20/23 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10435
eggNOG	1	0.900	-	-		E1_COG5063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4153
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000616
OrthoInspector	1	1.000	-	-		otm25344
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2078
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.950