DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tis11 and Zfp36l3

DIOPT Version :9

Sequence 1:	NP_001259490.1	Gene:	Tis11 / 32222	FlyBaseID:	FBgn0011837	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_001009549.1	Gene:	Zfp36l3 / 333473	MGIID:	3525151	Length:	725	Species:	Mus musculus

Alignment Length:	388	Identity:	112/388 - (28%)
Similarity:	143/388 - (36%)	Gaps:	148/388 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 HHGGLTRTISQPAQLIQQQQQQHQQQQQQQPAVASLVTITENLGNMNLHRKLERTQSEPLPPQQP 130
            |.......:||    |..:..:|..||:.:|...|        |:.:|
Mouse    82 HEPSEANAVSQ----IHPRNGEHSLQQKPKPQKVS--------GSSSL----------------- 117

  Fly   131 MNTSRYKTELCRPFEEAGECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCH 195
            ..:.||||||||||||:|.||||.|||||||..|||.:.||||||||.|||||||||||||.|||
Mouse   118 ATSERYKTELCRPFEESGICKYGHKCQFAHGYRELRTLSRHPKYKTEPCRTFHSVGFCPYGTRCH 182

  Fly   196 FVHNADEARAQQAAQAAKSSTQSQSQ-------------SQQSSSQNFSPKSNQSSNQSS----- 242
            |:||..|    |....::|:.:..|.             .||...|:.||....|.|..:
Mouse   183 FIHNQPE----QQPVLSESTLEEPSSFNGSNVLHLGVNGEQQPGLQSDSPSGFLSVNSQALQAPL 243

  Fly   243 NSSSSSSSSGG-------------------------------------GGGGGNSINN------- 263
            ..:..:.||||                                     .....||.|:
Mouse   244 QLNQQALSSGGVMPSSHPAAANLRMMCCRTSSSTTAHDADKDPDKDADKDPSNNSANDALAFPQE 308

  Fly   264 -----------------------NN--------GSQFYLPLSPPLSMSTGSDRESPTGSLSLSPT 297
                                   ||        .:||.:||:.||..:|      ..|..|:.|
Mouse   309 PGDFSPVAFQNPNTATTTPTAFYNNQQQMGLAASAQFQMPLARPLPSAT------IFGQASVGP- 366

  Fly   298 NSLTSFPFHDALQHGYLASNGAKSNSSASSTSSA-----SGMGLGMSMGIGQGMIIGQGLGMG 355
                      ||..|...:.||....:|:.|.:|     :.|.||.:|..|..|..|..|..|
Mouse   367 ----------ALTPGAAMAPGAALAPAAALTPAAALAPGAAMALGAAMATGAAMATGAALTPG 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_001259490.1	zf-CCCH	136..161	CDD:279036	21/24 (88%)
Tis11	NP_001259490.1	zf-CCCH	174..198	CDD:279036	21/23 (91%)
Zfp36l3	NP_001009549.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		11/65 (17%)
		zf-CCCH	123..148	CDD:279036	21/24 (88%)
		zf-CCCH	161..187	CDD:279036	22/25 (88%)
		Necessary for cytoplasmic localization. /evidence=ECO:0000269\|PubMed:18367448	193..711		45/244 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..310		3/33 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..709
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101179
Panther	1	1.100	-	-	O	PTHR12547
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.900